The Great Plains Laboratory | Urine Organic Acid Test (OAT)
Urine Organic Acid Test (OAT):
Note: Signature Required Upon Delivery
Test kits are PrePay with no option to bill medical insurance at any time.
Lab results are processed through the laboratory.
Lab results are mailed to the doctor and mailed to you directly from the laboratory.
Phone consults with the doctor are available, email your contact information to: firstname.lastname@example.org.
Great Plains Urine Organic Acid Test:
The Organic Acids Test (OAT) Provides A Metabolic Snapshot based on the products the body discards through the urine. These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. At certain levels, organic acids in urine may be indicators of toxicity or markersof metabolic pathways.
Metabolites of yeast or gastrointestinal bacteria appear against the background of normal human metabolites and provide an assessment of yeast and bacterial activity. The OAT offers the most complete and accurate evaluation of intestinal yeast and bacteria. These factors are of critical importance in and movement disorders.
Abnormal toxic metabolites of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, affect energy levels and immune function. Yeast can attach to the intestinal wall causing leaky gut syndrome, which can cause or magnify food allergies, impede absorption of vitamins and minerals, and cause intestinal disorders.
Many people with chronic illness, allergic conditions, and neurological disorders often have one or more abnormal organic acids in their system. Factors which can cause or affect the intestinal yeast overgrowth include oral antibiotic use, excessive sugars in the diet, selective or combined immune deficiencies, genetic and other factors.
Once any abnormalities are detected, there is a variety of treatment options available to treat the condition. Treatments include antifungal or antibacterial products, probiotic supplementation, vitamins, antioxidants and dietary modification.
Patients and physicians have reported significant improvement upon treatment including: decreased fatigue, regular bowel movements, increased energy and alertness, increased concentration, improved verbal skills, less hyperactivity, better sleeping habits, and decreased abdominal pain.
- Because the OAT and Amino Acids Test quantitate different markers for assessing GI function, detoxification capacity, and certain nutritional deficiencies, together they provide a more in-depth evaluation of overall nutritional status and digestive sufficiency.
- Sampling for the two tests at the same time strengthens the usefulness of the single tests.
- The tests show a total of 112 markers (74 OAT metabolites and 40 amino acids combined).
- Along with a physician's clinical assessment, a treatment plan can be designed from the two tests, including nutritional supplementation, treatments for dysbiosis, and indications for genetic testing.
- Simple testing—urine is collected at home and mailed to the lab.
New Markers: Analyte List
Quinolinic Acid - Marker for Inflammation and Neurotoxicity!
Quinolinic acid is an organic acid derived from the amino acid tryptophan and can be neurotoxic at high levels. Excitotoxic substances like quinolinic acid may stimulate nerve cells so much that the nerve cells die. Brain toxicity due to quinolinic acid has been implicated in Alzheimer's disease, autism, Huntington's disease, stroke, dementia from old age, depression, HIV-associated dementia, and schizophrenia.
Inorganic Phosphate - Marker for Bone Function / Vitamin D Deficiency!
Low phosphate is associated with hypoparathyroidism, pseudohypo-parathyroidism, low nutritional phosphate intake, parathyroidectomy, and vitamin D deficiency.
4-Hydroxybenzoic Acid - Marker for Exposure to Parabens!
4-Hydroxybenzoic acid is a metabolite of methylparaben, an anti-fungal agent, and a popular preservative in food and cosmetics. Parabens may be linked to mitochondrial failure due to depletion of cellular ATP through uncoupling of oxidative phosphorylation. They may also be produced from microbial metabolism of polyphenols in the diet. Parabens have been found at high levels in breast cancer samples, but a definitive relationship with breast cancer has not been demonstrated.
4-Hydroxyhippuric Acid - Marker for Exposure to Parabens!
4-Hydroxyhippuric, a glycine conjugate of 4-hydroxybenzoic acid, is a metabolite of methylparaben. This compound is increased from intake of fruits containing polyphenols rich in anthocyanins, flavonols, and hydroxycinnamates, which are metabolized by gastrointestinal bacteria. 4-Hydroxyhippuric acid has been found to be an inhibitor of Calcium-ATPase in end-stage renal failure.
Malic Acid - Marker for Mitochondrial Dysfunction!
When malic acid is simultaneously elevated with citric, fumaric, and alpha-ketoglutaric acids, it strongly suggests cytochrome C oxidase deficiency, indicating dysfunction in the mitochondrial energy pathways.
DHPPA - Marker for Beneficial Bacteria!
Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli mediate the breakdown of chlorogenic acid to 3,4-dihydroxyphenylpropionic acid (DHPPA). High values of DHPPA are associated with increased amounts of these bacteria in the gastrointestinal tract.
N-acetylcysteine (NAC) - Marker for Glutathione Precursor & Chelating Agent!
N-acetylcysteine is a powerful antioxidant that acts to increase the glutathione reserves in the body. It is found in body fluids but is also used as a nutritional supplement. N-acetylcysteine reduces the toxicity of drugs like acetaminophen (Tylenol) and protects against toxicity of mercury and other heavy metals. Low levels could indicate a glutathione deficiency.
Quinolinic Acid / 5-HIAA Ratio - Marker for Neurotoxicity and Inflammation!
A high ratio of quinolinic acid to the tryptophan metabolite 5-hydroxyindole-acetic acid, indicates excessive inflammation due to recurrent infections, excessive tryptophan intake, immune overstimulation, excessive adrenal production of cortisol, or excessive exposure to phthalates.
Other Important Markers!
Besides the new markers, the OAT still evaluates other important compounds including Krebs cycle and neurotransmitters. This reliable test detects the overgrowth of yeast and a bacteria species, Clostridia, commonly missed by conventional culture methods. These organisms and their metabolites can produce or magnify symptoms of many medical conditions. Identification of a yeast or bacterial overgrowth paired with a successful treatment can increase the chance of recovery.
Yeast: Intestinal growth of yeast & fungi, including Candida, are measured via by-product. High levels indicate an overgrowth.
Bacterial: Intestinal growth of bacteria, including Clostridia species, is measured via by-product. High levels indicate an overgrowth.
Oxalates: Elevations may indicate an excess of foods high in oxalates or Vitamin C, digestive disease, B6 deficiency, or intestinal yeast growth. Genetic markers indicate possible hyperoxaluria.
Glycolysis: Elevations may result from infection, exercise, or B vitamin deficiency. Very high levels may result from genetic metabolic disorders.
Krebs cycle: Abnormalities may result from nutrient deficiencies, microbial overgrowth, or glutathione (GSH) deficiency.
2-oxoglutaric: Low levels may result from regeneration of amino acids to remove excess ammonia.
Neurotransmitters: Metabolites of dopamine, norepinephrine, adrenaline, and serotonin are measured. Abnormalities may result from stress or poor detoxification, depression, toxic metal exposure, and rarely, specific tumors.
Pyrimidines: Slight elevations occur from folic acid deficiency. Significant abnormalities can indicate possible genetic dysfunction.
Fatty acids: Abnormalities can occur from ketogenic diets or fasting, intake of medium chain triglycerides, carnitine deficiency, or genetic disease.
Toxic indicators: Abnormalities can occur from deficiency of glutathione, excess ammonia, and aspartame ingestion.
Vitamin indicators: Abnormalities involving B12, B6, biotin, ascorbic acid are measured. Amino acids: Abnormalities indicate a possible genetic error.
Miscellaneous: Abnormalities can indicate GI microbial activity or genetic disease.
Understand vitamin and hormone metabolism
Determine capacity to generate energy
Evaluate intestinal wall integrity
Assess performance of the central nervous system
Evaluate muscle function
Reveal excessive levels of GI yeast
Reveal excessive levels of GI bacteria
Detect nutritional or antioxidant deficiencies
Determine problems in fatty acid metabolism
Determine oxalate imbalances
Depending on test results, follow-up may include:
Oral anti-fungal or anti-bacterial medications
Initiate detoxification protocols
Follow-up genetic testing
Sample Test Report: Organic Acid Test (OAT) Sample Report
NOTE: Due to The Great Plains Laboratory does not have a contract in the state of New York.
New York residents are not allowed to perform or mail this test kit for processing within or from the state of New York. Furthermore, The Great Plains Laboratory will not process this test kit mailed from the State of New York.
*If you are interested in performing this test kit, you will need to:
- Perform / Collect the specimen outside of the state of New York.
- Mail for processing from an address outside of the state of New York.
- Receive your results to the same address outside of the state of New York.
We are sorry for any inconvenience this may cause.