NO LONGER MANUFACTURED OR AVAILABLE ON THE MARKET
This listing is for educational purposes and to assist in helping to find alternative options for Pteridin-4. As we find more options, approved by Stephen Smith, M.D., we will list them below for your convenience.
EXPLORE OTHER OPTIONS TO PTERIDIN-4:
- INCREASE BH4 NATURALLY: Neo40 Professional, by HumanN may be useful with such conditions as; Specific methylation issues, MTHFR, PKU, Nitric Oxide production, BH4 production.
- POSSIBLE Rx: In doctor review, more information coming soon.
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Ecological Formulas, Pteridin-4 60 Capsules, Biopterin for Enzyme Pathways
Pteridin-4 is a homeopathic supplement that contains biopterin, a cofactor to critical enzyme pathways in human physiology.
Tetrahydrobiopterin Deficiency is a rare genetic, neurological disorder present at birth. It is caused by an inherited inborn error of metabolism. Tetrahydrobiopterin is a natural substance (coenzyme) that enhances the action of other enzymes. When Tetrahydrobiopterin is deficient, an abnormally high blood level of the amino acid phenylalanine, along with low levels of certain neurotransmitters, usually occurs. To avoid irreversible neurological damage, diagnosis and treatment of this progressive disorder is essential as early as possible in life.
The subdivisions of Tetrahydrobiopterin Deficiency are as follows:
- Tetrahydrobiopterin Synthesis
- GTP Cyclohydrolase I (GTPCH) Deficiency
- 6-Pyruvoyl Tetrahydropterin Synthase (PTPS) Deficiency
- Tetrahydrobiopterin Regeneration
- Pterin-4-alpha-Carbinolamine Dehydratase (PCD) Deficiency
- Dihydropteridine Reductase (DHPR) Deficiency
Ingredients:
Vitamin C (as ascorbic acid) 10 mg, Tetrahydrobiopterin (a stable form of the physiologic agent, biopterin) 2.5 mg.
Other ingredients:
Sucrose, Gelatin, L-Leucine.
Directions:
Take one or two capsules daily or as directed by a physician.
Bottle Contains: 60 Capsules
Storage:
Refrigerate and keep tightly closed to maintain product potency and to maximize shelf life.
History:
Tetrahydrobiopterin was discovered to play a role as an enzymatic cofactor. The first enzyme found to use tetrahydrobiopterin is phenylalanine hydroxylase (PAH).
Biosynthesis:
Tetrahydrobiopterin is biosynthesized from guanosine triphosphate (GTP) by three chemical reactions mediated by the enzymes GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR).
Functions:
Tetrahydrobiopterin has the following responsibilities as a cofactor:
-
Tryptophan hydroxylase (TPH) for the conversion of L-tryptophan (TRP) to 5-hydroxytryptophan (5-HTP)
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Phenylalanine hydroxylase (PAH) for conversion of L-phenylalanine (PHE) to L-tyrosine (TYR)
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Tyrosine hydroxylase (TH) for the conversion of L-tyrosine to L-DOPA (DOPA)
-
Nitric oxide synthase (NOS) for conversion of a guanidino nitrogen of L-arginine (L-Arg) to nitric oxide (NO)
-
Alkylglycerol monooxygenase (AGMO) for the conversion of 1-alkyl-sn-glycerol to 1-hydroxyalkyl-sn-glycerol
Resources:
- Please visit: WebMD for additional information and resources.
- National Library of Medicine: The effects of tetrahydrobiopterin (BH4) treatment on brain function in individuals with phenylketonuria.