Integrative Therapeutics Gluten Manager 60 Capsules
Gluten Manager™ is uniquely designed digestive enzyme that includes both endopeptidase and exopeptidase activity in the form of Tolerase® G and dipeptidyl-peptidase IV (also known as DPP-IV). The combination of activity causes degradation at both the ends as well as the middle of the gluten molecule.*1-4 This makes a small gluten molecule proline peptide for easier and more complete digestion.
Gluten Manager™ - Digestive Enzymes:
Avoiding dietary gluten can be a challenge. In a study of individuals with very high sensitivity to gluten that were following a gluten free diet, 66% suspected unintended exposure.7 Gluten can cause immunological and opioid-like effects on the nervous system of sensitive individuals. As gluten is a protein, it is typically broken down into small amino acids. However, gluten is comprised of gliadin which is difficult to digest due to the long proline peptides.
Gluten Manager has dual mechanism-of-action digestive enzymes that hydrolyzes gluten at both the middle and end of the gluten molecule through the use of prolyl-endopeptidase (Tolerase® G) and dipeptidyl-peptidase IV enzyme activity (DPP-IV)†. The use of both digestive enzymes degrades the proline peptide into smaller chains that can be more completely digested.
- Features microbial enzymes that are stable in acidic environments
- Helps support the breakdown of gluten
- Smaller peptide chains for easier digestion
Theoretical mechanism of action using Tolerase G & DPP-IV†
Serving Size: 2 Capsules
Servings per Container: 30
Quantity per Container: 60 Capsules
Amount Per Serving:
|Ingredient||Amount||% Daily Value|
Microbial Enzymes Proprietary Protease Blend providing
Tolerase® G Prolyl Endopeptidase 240,000 PPI
Dipeptidyl Peptidase (DPP-IV) Activity 100,000 HUT
Directions and/or Dosage:
Take 1 or 2 capsules at the beginning of each meal or as recommended by your healthcare professional.
hydroxypropyl methylcellulose (vegetable capsule), cellulose, calcium laurate, silicon dioxide.
Does Not Contain:
Ingredients of animal origin
Caution: While Gluten Manager will reduce the level of reactive gliadin and gluten proteins in a meal, it is advised that celiac disease sufferers continue with their normal gluten exclusion diet as even small amounts of gliadin can cause adverse reactions in the most sensitized individuals. If pregnant, nursing or taking prescription drugs, consult your healthcare professional prior to use.
Tolerase® G is not intended to replace a gluten-free diet. Tolerase® G is not intended to treat or prevent celiac disease.
Tolerase G® is a trademark of DSM
- Salden BN, Monserrat V, Troost FJ, et al. Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers. Aliment Pharmacol Ther. 2015 Aug;42(3):273-85.
- Mitea C, Havenaar R, Drijfhout JW, et al. Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease. Gut. 2008 Jan;57(1):25-32.
- Stepniak D, Spaenij-Dekking L, Mitea C, et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G621-9.
- Ehren J, Morón B, Martin E, et al. A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One. 2009 Jul 21;4(7):e6313.
- Montserrat V, Bruins MJ, Edens L, Koning F. Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation. Food Chem. 2015 May 1;174:440-5.
- Tack GJ, van de Water JM, Bruins MJ, et al. Consumption of gluten with gluten-degrading enzyme by celiac patients: a pilot-study. World J Gastroenterol. 2013 Sep 21;19(35):5837-47.
- J. A. Silvester, L. A. Graff, L. Rigaux, J. R. Walker, D. R. Duerksen. Alimentary Pharmacol Ther. 2016 Sept;44(6):612-619.