Integrative Therapeutics Indolplex With BR-DIM 60 Tablets

Dietary Supplement! Indolplex® with BR-DIM® is a dietary supplement containing diindolylmethane (DIM®) to support healthy estrogen metabolism.* Research shows DIM promotes healthy estrogen metabolism by increasing the production of 2-hydroxyestrone estrogen metabolites over the undesirable 16-hydroxyestrone estrogen metabolites.* Promotes healthy cell development. Features a patented form of DIM that is...
Title :
$ 51.00

Integrative Therapeutics

Cancer Support

30 In Stock


Dietary Supplement!

Indolplex® with BR-DIM® is a dietary supplement containing diindolylmethane (DIM®) to support healthy estrogen metabolism.* Research shows DIM promotes healthy estrogen metabolism by increasing the production of 2-hydroxyestrone estrogen metabolites over the undesirable 16-hydroxyestrone estrogen metabolites.*

  • Promotes healthy cell development.
  • Features a patented form of DIM that is 10 times more potent than its precursor, indol-3 carbinol (I3C)
  • d absorption and bioavailability
  • Also available in tablets
  • This product contains no sugar, salt, yeast, wheat, gluten, dairy products, artificial flavoring, preservatives, ingredients of animal origin

Supplement Facts:

Serving Size: 2 Tablets

Servings per Container: 30

Quantity per Container: 60 Tablets

Amount Per Serving:

Ingredient Amount % Daily Value
Calcium (as calcium carbonate) 680 mg 68%
Indolplex® Complex 
modified food starch, 25% diindolylmethane (DIM®), Tocophersolan, phosphatidylcholine and silicon dioxide
240 mg *

Directions and/or Dosage:

Take 2 tablets daily with food, or as recommended by your healthcare professional. If less support is needed, take 1 tablet daily with food.

Other Ingredients:
Cellulose, modified cellulose, modified cellulose gum, silicon dioxide, stearic acid, magnesium stearate, titanium dioxide color, soy lecithin, vegetable glycerin, and carnauba wax.

Does Not Contain:

  • Artificial flavoring
  • Dairy products
  • Gluten
  • Ingredients of animal origin
  • Preservatives
  • Salt
  • Sugar
  • Wheat
  • Yeast

Do not use if pregnant or nursing. If taking prescription drugs, consult your healthcare professional prior to use. Harmless changes in urine color may occur with the use of this product.

Indolplex and DIM are registered trademarks of and is licensed from BioResponse, L.L.C.; U.S. Patent 6,086,915.

Research on DIM:


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Wortelboer, H. M., de Kruif, C. A., van Iersel, A. A., Falke, H. E., Noordhoek, J., and Blaauboer, B. J. Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes. Biochem.Pharmacol. 4-1-1992;43(7):1439-1447.

Wortelboer, H. M., van der Linden, E. C., de Kruif, C. A., Noordhoek, J., Blaauboer, B. J., van Bladeren, P. J., and Falke, H. E. Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures. Food Chem.Toxicol. 1992;30(7):589-599.


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Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer 2004;50(2):161-167.

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Ahmad, A., Kong, D., Wang, Z., Sarkar, S. H., Banerjee, S., and Sarkar, F. H. Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells. J.Cell Biochem. 11-1-2009;108(4):916-925.

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Gross-Steinmeyer, K., Stapleton, P. L., Liu, F., Tracy, J. H., Bammler, T. K., Quigley, S. D., Farin, F. M., Buhler, D. R., Safe, S. H., Strom, S. C., and Eaton, D. L. Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica 2004;34(7):619-632.

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Hong, C., Firestone, G. L., and Bjeldanes, L. F. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. Biochem.Pharmacol. 3-15-2002;63(6):1085-1097.

Hong, C., Kim, H. A., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Carcinogenesis 2002;23(8):1297-1305.

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