Integrative Therapeutics, Indolplex With BR-DIM 60 Tablets

Features Promotes healthy cell development. Features a patented form of DIM that is 10 times more potent than its precursor, indol-3 carbinol (I3C) Enhanced absorption and bioavailability Also available in tablets This product contains no sugar, salt, yeast, wheat, gluten, dairy products, artificial flavoring, preservatives, ingredients of animal origin  ...
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$ 51.00

Integrative Therapeutics

Cancer Support

28 In Stock

Features

  • Promotes healthy cell development.
  • Features a patented form of DIM that is 10 times more potent than its precursor, indol-3 carbinol (I3C)
  • Enhanced absorption and bioavailability
  • Also available in tablets
  • This product contains no sugar, salt, yeast, wheat, gluten, dairy products, artificial flavoring, preservatives, ingredients of animal origin

 

Indolplex® with BR-DIM® is a dietary supplement containing diindolylmethane (DIM®) to support healthy estrogen metabolism.* Research shows DIM promotes healthy estrogen metabolism by increasing the production of 2-hydroxy estrone estrogen metabolites over the undesirable 16-hydroxy estrone estrogen metabolites.*

Provides diindolylmethane (DIM) to support healthy estrogen metabolism.*

Indolplex® with BR-DIM® is a dietary supplement that contains a patented, bioavailable form of diindolylmethane (DIM®), a dietary indole naturally present in cruciferous vegetables. Research shows DIM promotes healthy estrogen metabolism by increasing the production of 2-hydroxy estrone estrogen metabolites over the undesirable 16-hydroxy estrone estrogen metabolites.* These critical metabolites have been shown to promote healthy cell development.*

    Supplement Facts:

    Serving Size: 2 Tablets

    Servings per Container: 30

    Quantity per Container: 60 Tablets

    Amount Per Serving:

    Ingredient Amount % Daily Value
    Calcium (as calcium carbonate) 680 mg 68%
    Indolplex® Complex 
    modified food starch, 25% diindolylmethane (DIM®), Tocophersolan, phosphatidylcholine, and silicon dioxide
    240 mg *
    † Based on 2000 calorie diet
    ** Daily Value (DV) not established

    Directions and/or Dosage:

    Take 2 tablets daily with food, or as recommended by your healthcare professional. If less support is needed, take 1 tablet daily with food.

    Other Ingredients:
    Cellulose, modified cellulose, modified cellulose gum, silicon dioxide, stearic acid, magnesium stearate, titanium dioxide color, soy lecithin, vegetable glycerin, and carnauba wax.

    Does Not Contain:

    • Artificial flavoring
    • Dairy products
    • Gluten
    • Ingredients of animal origin
    • Preservatives
    • Salt
    • Sugar
    • Wheat
    • Yeast

     

    Warning:

    Do not use if pregnant or nursing. If taking prescription drugs, consult your healthcare professional prior to use. Harmless changes in urine color may occur with the use of this product.

    Notes:
    Indolplex and DIM are registered trademarks of and are licensed from BioResponse, L.L.C.; U.S. Patent 6,086,915.

    Research on DIM:

    References:

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    Ý_

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    Ahmad, A., Kong, D., Wang, Z., Sarkar, S. H., Banerjee, S., and Sarkar, F. H. Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells. J.Cell Biochem. 11-1-2009;108(4):916-925.

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    Gong, Y., Firestone, G. L., and Bjeldanes, L. F. 3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells. Mol.Pharmacol. 2006;69(4):1320-1327.

    Gong, Y., Sohn, H., Xue, L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Cancer Res. 5-1-2006;66(9):4880-4887.

    Gross-Steinmeyer, K., Stapleton, P. L., Liu, F., Tracy, J. H., Bammler, T. K., Quigley, S. D., Farin, F. M., Buhler, D. R., Safe, S. H., Strom, S. C., and Eaton, D. L. Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica 2004;34(7):619-632.

    Gross-Steinmeyer, K., Stapleton, P. L., Tracy, J. H., Bammler, T. K., Strom, S. C., Buhler, D. R., and Eaton, D. L. Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicol Sci. 2009;112(2):303-310.

    Gullett, N. P., Ruhul Amin, A. R., Bayraktar, S., Pezzuto, J. M., Shin, D. M., Khuri, F. R., Aggarwal, B. B., Surh, Y. J., and Kucuk, O. Cancer prevention with natural compounds. Semin.Oncol. 2010;37(3):258-281.

    Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.Res. 2010;2(4):402-411.

    Hestermann, E. V. and Brown, M. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol.Cell Biol. 2003;23(21):7920-7925.

    Hong, C., Firestone, G. L., and Bjeldanes, L. F. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. Biochem.Pharmacol. 3-15-2002;63(6):1085-1097.

    Hong, C., Kim, H. A., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Carcinogenesis 2002;23(8):1297-1305.

    Hong, J., Samudio, I., Liu, S., Abdelrahim, M., and Safe, S. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology 2004;145(12):5774-5785.

    Hsu, E. L., Chen, N., Westbrook, A., Wang, F., Zhang, R., Taylor, R. T., and Hankinson, O. CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. Cancer Lett. 6-28-2008;265(1):113-123.

    Hsu, E. L., Chen, N., Westbrook, A., Wang, F., Zhang, R., Taylor, R. T., and Hankinson, O. Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals. J.Oncol. 2009;2009:491985.

    Hsu, J. C., Zhang, J., Dev, A., Wing, A., Bjeldanes, L. F., and Firestone, G. L. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. Carcinogenesis 2005;26(11):1896-1904.

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    Huang, Z., Zuo, L., Zhang, Z., Liu, J., Chen, J., Dong, L., and Zhang, J. 3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway. Free Radic.Biol.Med. 1-15-2011;50(2):228-236.

    Ichite, N., Chougule, M. B., Jackson, T., Fulzele, S. V., Safe, S., and Singh, M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin.Cancer Res. 1-15-2009;15(2):543-552.

    Ichite, N., Chougule, M., Patel, A. R., Jackson, T., Safe, S., and Singh, M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Mol.Cancer Ther. 2010;9(11):3003-3014.

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    Jellinck, P. H., Makin, H. L., Sepkovic, D. W., and Bradlow, H. L. Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes. J.Steroid Biochem.Mol. Biol. 1993;46(6):791-798.

    Jin, Y., Zou, X., and Feng, X. 3,3'-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells. Anticancer Drugs 2010;21(9):814-822.

    Kandala, P. K. and Srivastava, S. K. Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 2010;78(2):297-309.

    Kassie, F., Anderson, L. B., Scherber, R., Yu, N., Lahti, D., Upadhyaya, P., and Hecht, S. S. Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. Cancer Res. 7-1-2007;67(13):6502-6511.

    Kassie, F., Melkamu, T., Endalew, A., Upadhyaya, P., Luo, X., and Hecht, S. S. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and Myo-inositol, alone and in combination. Carcinogenesis 2010;31(9):1634-1641.

    Katchamart, S., Stresser, D. M., Dehal, S. S., Kupfer, D., and Williams, D. E. Concurrent flavin-containing monooxygenase down-regulation and cytochrome P-450 induction by dietary indoles in the rat: implications for drug-drug interaction. Drug Metab Dispos. 2000;28(8):930-936.

    Khwaja, F. S., Wynne, S., Posey, I., and Djakiew, D. 3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cells. Cancer Prev.Res.(Phila) 2009;2(6):566-571.

    Kim, E. J., Park, H., Kim, J., and Park, J. H. 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. Mol.Carcinog. 2010;49(7):672-683.

    Kim, E. J., Park, S. Y., Shin, H. K., Kwon, D. Y., Surh, Y. J., and Park, J. H. Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. J.Nutr. 2007;137(1):31-36.

    Kim, E. J., Shin, M., Park, H., Hong, J. E., Shin, H. K., Kim, J., Kwon, D. Y., and Park, J. H. Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. J.Nutr. 2009;139(12):2373-2379.

    Kim, Y. H., Kwon, H. S., Kim, D. H., Shin, E. K., Kang, Y. H., Park, J. H., Shin, H. K., and Kim, J. K. 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Inflamm.Bowel.Dis. 2009;15(8):1164-1173.

    Kim, Y. S., and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73.

    Kong, D., Banerjee, S., Huang, W., Li, Y., Wang, Z., Kim, H. R., and Sarkar, F. H. Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. Cancer Res. 3-15-2008;68(6):1927-1934.

    Kong, D., Li, Y., Wang, Z., Banerjee, S., and Sarkar, F. H. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res. 4-1-2007;67(7):3310-3319.

    Kunimasa, K., Kobayashi, T., Kaji, K., and Ohta, T. Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC. J.Nutr. 2010;140(1):1-6.

    Le, H. T., Schaldach, C. M., Firestone, G. L., and Bjeldanes, L. F. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J.Biol.Chem. 6-6-2003;278(23):21136-21145.

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    Agape Nutrition Inventory Update

    We have received unprecedented demand across a wide range of categories as the impact of coronavirus COVID-19 has continued to spread over the past several months, and as a result, have experienced several availability issues.

    We are working very closely with our manufacture and supplier partners to quickly increase availability across all product categories. We are now operating normally with intermittent out of stock levels, which generally do not last long and are quickly being replenished by our brand partners.

     

    Please Be Aware of Any Possible Shipping Delays:

    (1) Slight delays with fulfillment processing may occur as manufacture and distributor warehouses are experiencing higher than normal volume and demand for nutritional items.

    (2) Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and/or natural disasters. Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Please reach out to the shipping carrier for more information.

    (3) Please be aware of severe weather conditions in or around your location and surrounding states that my affect the timeliness of delivery.

     

    Orders cannot be cancelled once the order confirmation is received.

    Agape Nutrition is proud to offer: United States Postal Service (USPS) and United Parcel Service (UPS) as our standard shipping carriers and their services. Shipping rates are determined in real time or carrier book rate by weight and distance. Shipping Options are determined and reflected upon check out, for your choosing. If an option below is not listed upon check out, your package may not meet the weight requirement or the service may not be available to the address location. You will receive an automated invoice of your order in your email inbox. Tracking is generally applied within 24 to 48 hours of receipt, unless otherwise notified.

     

    We pride ourselves on providing fast service at competitive prices.

    Orders received by 12:00 pm Pacific Standard Time (PST) are generally processed within 24 to 48 hours, which is dependent upon the daily order volume. Although, most orders are processed and shipped within 24 hours of receipt, this is not a guarantee. Tracking is updated within 24 to 48 hours after processing and the package has shipped.

     

    NOTE: Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and/or natural disasters.

    NOTE: Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Due to no carrier guarantees, delayed or late packages are not eligible for refunds. This is a stipulation directly from the shipping carriers and is out of our control.

    The Shipping Service Guarantee Remains Suspended for Most Shipments

    *Please reach out to the shipping carrier for more information.

     

    USPS Holiday Schedule             Agape Nutrition Holiday Schedule                 UPS Holiday Schedule

    USPS Services (Business Days) UPS Services (Business Days)
    1-3 Days USPS First-Class Mail 2 Days UPS 2 Day Air
    1-3 Days USPS Priority Mail 3 Days UPS 3 Day Select
    2-9 Days USPS Parcel Select 1-7 Days UPS Ground

    Please Note: No Saturday Delivery.

    FREE SHIPPING is offered to orders that meet or exceed $99, by applying the promo code: FREESHIP and click the ADD button upon check out. FREE SHIPPING is USPS Standard delivery service or UPS Standard Ground, if the first option is not available to your shipping location. Offer excludes specialty products and other discounts.

    If FREE SHIPPING is not desired, simply do not apply the promo code. All available shipping options for your order will be displayed.


    All discounts and promotional offers are calculated before shipping and handling rates are applied.


    ORDER CANCELLATIONS

    Orders cannot be cancelled or changed once the order has been placed and the confirmation is received.

    • Products may process and ship faster then expected.
    • Products may be automated to process directly after the order is confirmed.
    • Product warehouses may be in different states and time zones.
    • Orders may take up to 72 hours to process a cancellation or change. 

    Products may ship faster then expected, and many are automated to process directly after order confirmation. We work directly with top professional manufactures and distributors from across the United States, in all time zones. There are a lot of cogs and wheels turning to process and ship your order efficiently to meet an on time delivery target. When you request a cancellation or change of an order, it may take up to 72 hours to process your request. This process may involve voiding orders in computer systems, removing items from back order logs, pulling items from production schedules and sometimes stopping orders at the shipping dock or warehouse. Our order fulfillment may be performed by many quick hands, in different states and time zones. Therefore, we cannot offer or guarantee order cancellations after the order has been received.


    Payment Method
    Orders should be placed via the web with payment by MasterCard, Visa, Discover, American Express, PayPal or Amazon Pay, etc.

    Domestic Orders
    Agape Nutrition is proud to ship to 62 states and territories of the United States.

    • All 50 United States
    • Armed Forces: Americas (AA)

    Orders shipped to U.S. military addresses (APO/FPO/DPO) will ship via United States Postal Service (USPS) at the carrier book rate; delivery of these orders may be delayed by one (1) business day.

    International Orders
    Agape Nutrition does not offer international orders or shipping at this time, outside the 62 states and territories of the United States.

    Heat Sensitive Orders
    Products requiring shipment in a cool environment (perishable and frozen items) are subject to special shipping procedures due to their sensitive nature to ensure customers receive products in good condition. Heat sensitive items are shipped using sealed thermal bubble bag, ice pack or brick, resealable bag and extra padding to ensure a cool environment. We do not recommend heat sensitive item ship to territories of the United States, and we cannot be held responsible for cooled environment degradation to these destinations.

    Agape Nutrition recommends that heat sensitive products ship with your preference of any 1-3 Day delivery service. We do not offer overnight or next day delivery service at this time. Saturday delivery is not available or guaranteed, unless offered by the shipping carrier as part of the normal delivery.

    Please Note:

    • All heat sensitive items will ship on Monday and Tuesday only. This is the ensure that heat sensitive orders are delivered before weekends.
    • Heat sensitive items are not eligible for return, credit, or refund. As we cannot guarantee cool storage or efficacy of the product, after the order has been delivered.
    • Delays in shipping service delivery, caused an issue? See our return policy for further information.

    Drop Ship Orders

    Shipping may be different from the warehouse(s) we work with, however we do our best to match the pricing and type of shipping originally selected. Please note that some manufactures add 1-2 days for their processing times before shipping your order.

    Signature is required for:

    • Orders of a high dollar amount.
    • Biotics Research NW shipments.
    • Vielight shipments.
    • Richway shipments.
    • All electronic devices.
    • All laboratory test kits.

    Drop ship orders may be utilized in the following scenarios:

    • Out of stock in our dispensary.
    • Allows faster shipping time.
    • Special order items.
    • Drop ship only item.

      Quantity Discounts
      May be available on specific items only. Discounts will be available on the item order page, with the volume and discount clearly indicated.

      We do not offer commercial entity fulfillment (wholesaler, distributor, re-seller). Orders are processed for quantities of personal consumption only. Accounts are monitored and deactivated for misuse, at Agape Nutrition's discretion.

      Out of Stock Items
      If an item ordered is out of stock with the manufacture or any warehouse we work with, you will automatically receive the remainder of your order.

      • We may:  search for another fulfillment warehouse in order to drop ship your item.
      • We may:  notify you if the item can be fulfilled within 1-2 weeks, so that you may choose to wait for fulfillment or cancel the order.
      • We may:  cancel the item or order for a full refund. You will be notified by email of any unfulfillable cancellations.

      Package Delays

      Please be aware of severe weather and hazardous conditions in your area or other states that may affect the timeliness of your package delivery. Agape Nutrition can not be responsible for severe weather and unforeseen incidents that may impact the processing times and/or shipping services. We will work to ensure the safety of our employees while minimizing effects on service. Contingency plans are in place to help ensure that shipments arrive at their final destinations as quickly as conditions permit.

      Price Changes
      All prices are subject to change without notice. Agape Nutrition is not liable for errors or omissions.

       

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