The Great Plains Laboratory | Urine Organic Acid Test (OAT)
Urine Organic Acid Test (OAT):
Note: Signature Required Upon Delivery
How it works
- Test kits & lab fees are pre-paid through Agape Nutrition, with no option to bill medical insurance at any time.
- Fill out paperwork in box or submit electronically, Stephen Smith M.D. is the referring physician.
- Perform test kit, mail with paperwork, using prepaid envelope.
- Test kits are processed through The Great Plains Laboratory.
- Results within 3-4 weeks after lab processing.
- The doctor is notified of results through our portal and then emailed to you.
- Schedule a phone consult with Dr. Stephen Smith or your own licensed healthcare physician.
Separate phone consults with the doctor, Stephen Smith M.D., are available. Informational is included in your order.
Great Plains Urine Organic Acid Test:
The Organic Acids Test (OAT) Provides A Metabolic Snapshot based on the products the body discards through the urine. These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. At certain levels, organic acids in urine may be indicators of toxicity or markers of metabolic pathways.
Metabolites of yeast or gastrointestinal bacteria appear against the background of normal human metabolites and provide an assessment of yeast and bacterial activity. The OAT offers the most complete and accurate evaluation of intestinal yeast and bacteria. These factors are of critical importance in and movement disorders.
Abnormal toxic metabolites of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, affect energy levels and immune function. Yeast can attach to the intestinal wall causing leaky gut syndrome, which can cause or magnify food allergies, impede absorption of vitamins and minerals, and cause intestinal disorders.
Many people with chronic illness, allergic conditions, and neurological disorders often have one or more abnormal organic acids in their system. Factors which can cause or affect the intestinal yeast overgrowth include oral antibiotic use, excessive sugars in the diet, selective or combined immune deficiencies, genetic and other factors.
Once any abnormalities are detected, there is a variety of treatment options available to treat the condition. Treatments include antifungal or antibacterial products, probiotic supplementation, vitamins, antioxidants and dietary modification.
Patients and physicians have reported significant improvement upon treatment including: decreased fatigue, regular bowel movements, increased energy and alertness, increased concentration, improved verbal skills, less hyperactivity, better sleeping habits, and decreased abdominal pain.
New Markers: Analyte List
Quinolinic Acid - Marker for Inflammation and Neurotoxicity!
Quinolinic acid is an organic acid derived from the amino acid tryptophan and can be neurotoxic at high levels. Excitotoxic substances like quinolinic acid may stimulate nerve cells so much that the nerve cells die. Brain toxicity due to quinolinic acid has been implicated in Alzheimer's disease, autism, Huntington's disease, stroke, dementia from old age, depression, HIV-associated dementia, and schizophrenia.
Inorganic Phosphate - Marker for Bone Function / Vitamin D Deficiency!
Low phosphate is associated with hypoparathyroidism, pseudohypo-parathyroidism, low nutritional phosphate intake, parathyroidectomy, and vitamin D deficiency.
4-Hydroxybenzoic Acid - Marker for Exposure to Parabens!
4-Hydroxybenzoic acid is a metabolite of methylparaben, an anti-fungal agent, and a popular preservative in food and cosmetics. Parabens may be linked to mitochondrial failure due to depletion of cellular ATP through uncoupling of oxidative phosphorylation. They may also be produced from microbial metabolism of polyphenols in the diet. Parabens have been found at high levels in breast cancer samples, but a definitive relationship with breast cancer has not been demonstrated.
4-Hydroxyhippuric Acid - Marker for Exposure to Parabens!
4-Hydroxyhippuric, a glycine conjugate of 4-hydroxybenzoic acid, is a metabolite of methylparaben. This compound is increased from intake of fruits containing polyphenols rich in anthocyanins, flavonols, and hydroxycinnamates, which are metabolized by gastrointestinal bacteria. 4-Hydroxyhippuric acid has been found to be an inhibitor of Calcium-ATPase in end-stage renal failure.
Malic Acid - Marker for Mitochondrial Dysfunction!
When malic acid is simultaneously elevated with citric, fumaric, and alpha-ketoglutaric acids, it strongly suggests cytochrome C oxidase deficiency, indicating dysfunction in the mitochondrial energy pathways.
DHPPA - Marker for Beneficial Bacteria!
Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli mediate the breakdown of chlorogenic acid to 3,4-dihydroxyphenylpropionic acid (DHPPA). High values of DHPPA are associated with increased amounts of these bacteria in the gastrointestinal tract.
N-acetylcysteine (NAC) - Marker for Glutathione Precursor & Chelating Agent!
N-acetylcysteine is a powerful antioxidant that acts to increase the glutathione reserves in the body. It is found in body fluids but is also used as a nutritional supplement. N-acetylcysteine reduces the toxicity of drugs like acetaminophen (Tylenol) and protects against toxicity of mercury and other heavy metals. Low levels could indicate a glutathione deficiency.
Quinolinic Acid / 5-HIAA Ratio - Marker for Neurotoxicity and Inflammation!
A high ratio of quinolinic acid to the tryptophan metabolite 5-hydroxyindole-acetic acid, indicates excessive inflammation due to recurrent infections, excessive tryptophan intake, immune overstimulation, excessive adrenal production of cortisol, or excessive exposure to phthalates.
Other Important Markers!
Besides the new markers, the OAT still evaluates other important compounds including Krebs cycle and neurotransmitters. This reliable test detects the overgrowth of yeast and a bacteria species, Clostridia, commonly missed by conventional culture methods. These organisms and their metabolites can produce or magnify symptoms of many medical conditions. Identification of a yeast or bacterial overgrowth paired with a successful treatment can increase the chance of recovery.
Yeast: Intestinal growth of yeast & fungi, including Candida, are measured via by-product. High levels indicate an overgrowth.
Bacterial: Intestinal growth of bacteria, including Clostridia species, is measured via by-product. High levels indicate an overgrowth.
Oxalates: Elevations may indicate an excess of foods high in oxalates or Vitamin C, digestive disease, B6 deficiency, or intestinal yeast growth. Genetic markers indicate possible hyperoxaluria.
Glycolysis: Elevations may result from infection, exercise, or B vitamin deficiency. Very high levels may result from genetic metabolic disorders.
Krebs cycle: Abnormalities may result from nutrient deficiencies, microbial overgrowth, or glutathione (GSH) deficiency.
2-oxoglutaric: Low levels may result from regeneration of amino acids to remove excess ammonia.
Neurotransmitters: Metabolites of dopamine, norepinephrine, adrenaline, and serotonin are measured. Abnormalities may result from stress or poor detoxification, depression, toxic metal exposure, and rarely, specific tumors.
Pyrimidines: Slight elevations occur from folic acid deficiency. Significant abnormalities can indicate possible genetic dysfunction.
Fatty acids: Abnormalities can occur from ketogenic diets or fasting, intake of medium chain triglycerides, carnitine deficiency, or genetic disease.
Toxic indicators: Abnormalities can occur from deficiency of glutathione, excess ammonia, and aspartame ingestion.
Vitamin indicators: Abnormalities involving B12, B6, biotin, ascorbic acid are measured. Amino acids: Abnormalities indicate a possible genetic error.
Miscellaneous: Abnormalities can indicate GI microbial activity or genetic disease.
Understand vitamin and hormone metabolism
Determine capacity to generate energy
Evaluate intestinal wall integrity
Assess performance of the central nervous system
Evaluate muscle function
Reveal excessive levels of GI yeast
Reveal excessive levels of GI bacteria
Detect nutritional or antioxidant deficiencies
Determine problems in fatty acid metabolism
Determine oxalate imbalances
Depending on test results, follow-up may include:
Oral anti-fungal or anti-bacterial medications
Initiate detoxification protocols
Follow-up genetic testing
Sample Test Report: Organic Acid Test (OAT) Sample Report
NOTE: Due to The Great Plains Laboratory does not have a contract in the state of New York.
New York residents are not allowed to perform or mail this test kit for processing within or from the state of New York. Furthermore, The Great Plains Laboratory will not process this test kit mailed from the State of New York.
*If you are interested in performing this test kit, you will need to:
- Perform / Collect the specimen outside of the state of New York.
- Mail for processing from an address outside of the state of New York.
- Receive your results to the same address outside of the state of New York.
We are sorry for any inconvenience this may cause.
Agape Nutrition Inventory Update
We have received unprecedented demand across a wide range of categories as the impact of coronavirus COVID-19 has continued to spread over the past several months, and as a result, have experienced several availability issues.
We are working very closely with our manufacture and supplier partners to quickly increase availability across all product categories. We are now operating normally with intermittent out of stock levels, which generally do not last long and are quickly being replenished by our brand partners.
Orders cannot be cancelled once the order confirmation is received.
Agape Nutrition is proud to offer: United States Postal Service (USPS) and United Parcel Service (UPS) as our standard shipping carriers and their services. Shipping rates are determined in real time or carrier book rate by weight and distance. Shipping Options are determined and reflected upon check out, for your choosing. If an option below is not listed upon check out, your package may not meet the weight requirement or the service may not be available to the address location. You will receive an automated invoice of your order in your email inbox. Tracking is generally applied within 24 to 48 hours of receipt, unless otherwise notified.
We pride ourselves on providing fast service at competitive prices.
Orders received by 12:00 pm Pacific Standard Time (PST) are generally processed within 24 to 48 hours, which is dependent upon the daily order volume. Although, most orders are processed and shipped within 24 hours of receipt, this is not a guarantee. Tracking is updated within 24 to 48 hours after processing and the package has shipped.
|USPS Services (Business Days)||UPS Services (Business Days)|
|1-3 Days||USPS First-Class Mail||2 Days||UPS 2 Day Air|
|1-3 Days||USPS Priority Mail||3 Days||UPS 3 Day Select|
|2-9 Days||USPS Parcel Select||1-7 Days||UPS Ground|
Please Note: No Saturday Delivery.
FREE SHIPPING is offered to orders that meet or exceed $99, by applying the promo code: FREESHIP and click the ADD button upon check out. FREE SHIPPING is USPS Standard delivery service or UPS Standard Ground, if the first option is not available to your shipping location. Offer excludes specialty products and other discounts.
If FREE SHIPPING is not desired, simply do not apply the promo code. All available shipping options for your order will be displayed.
All quantity discounts and promotional offers are calculated before shipping and handling rates are applied.
Orders cannot be cancelled once the order confirmation is received.
When you request a cancellation of an order or item it may take up to 72 hours to process your cancellation claim. This process may involve voiding orders in computer systems, removing items from back order logs, having operations personnel pull items from production schedules and sometimes stopping orders at the shipping dock. Also note that sometimes products ship more quickly than expected, so we recommend that you do not purchase alternative products until receiving final confirmation of your cancellation.
Orders should be placed via the web with payment by MasterCard, Visa, Discover, American Express, PayPal or Amazon Pay, etc.
Agape Nutrition is proud to ship to 62 states and territories of the United States.
- All 50 United States
- Armed Forces: Americas (AA)
Orders shipped to U.S. military addresses (APO/FPO/DPO) will ship via United States Postal Service (USPS) at the carrier book rate; delivery of these orders may be delayed by one (1) business day.
Agape Nutrition does not offer international shipping at this time, outside the 50 states of the United States.
Heat Sensitive Orders
Products requiring shipment in a cool environment (perishable and frozen items) are subject to special shipping procedures due to their sensitive nature to ensure customers receive products in good condition. Heat sensitive items are shipped using sealed thermal bubble bag, ice pack or brick, resealable bag and extra padding to ensure a cool environment.
Agape Nutrition recommends that heat sensitive products ship with your preference of any 1-3 Day delivery service. We do not offer overnight or next day delivery service at this time, and Saturday delivery is not available.
- All heat sensitive items will ship on Monday and Tuesday only.
- Heat sensitive items are not eligible for return, credit, or refund.
Drop Ship Orders
Shipping may be different from the warehouse(s) we work with, however we do our best to match the pricing and type of shipping originally selected. Please note that some manufactures add 1-3 days for their processing times before shipping your order.
Signature is required for:
- Orders of a high dollar amount.
- Biotics Research NW shipments.
- Vielight shipments.
- Richway shipments.
- All electronic devices.
- All laboratory test kits.
Drop ship orders may be utilized in the following scenarios:
- Out of stock in our dispensary.
- Allows faster shipping time.
- Special order items.
- Drop ship only item.
May be available on specific items only. Discounts will be available on the item order page, with the volume and discount clearly indicated.
We do not offer commercial entity fulfillment (wholesaler, distributor, re-seller). Orders are processed for quantities of personal consumption only. Accounts are monitored for misuse.
Out of Stock Items
If an item ordered is out of stock with the manufacture or any warehouse we work with, you will automatically receive the remainder of your order. We may:
- search for another fulfillment warehouse in order to drop ship your item.
- notify you if the item can be fulfilled in a short amount of time.
- cancel the item or order for a full refund. You will be notified by email of any cancellations.
Please be aware of severe weather and hazardous conditions in your area or other states that may affect the timeliness of your package delivery. Agape Nutrition can not be responsible for severe weather and unforeseen incidents that may impact the processing times and/or shipping services. We will work to ensure the safety of our employees while minimizing effects on service. Contingency plans are in place to help ensure that shipments arrive at their final destinations as quickly as conditions permit.
All prices are subject to change without notice. Agape Nutrition is not liable for errors or omissions.