The Great Plains Laboratory, Urine Organic Acid Test (OAT)

The Great Plains Laboratory

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Laboratory Testing

Easy to use urine organic test kit Test kits, postage, and laboratory fees are prepaid through Agape Nutrition No need to bill medical insurance for the tests The Great Plains Laboratory processes test kits Results available with three to four weeks after processing Choose to arrange a phone call with...
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  • Easy to use urine organic test kit
  • Test kits, postage, and laboratory fees are prepaid through Agape Nutrition
  • No need to bill medical insurance for the tests
  • The Great Plains Laboratory processes test kits
  • Results available with three to four weeks after processing
  • Choose to arrange a phone call with Dr. Stephen Smith or your own healthcare
  • professional
  • Detect a range of markers from inflammation and neurotoxicity to mitochondrial
  • dysfunction and beneficial bacteria
  • Easy to Use Specimen Test, Detect Genetic Errors and Intestinal Microbial Activity


The Great Plains Laboratory Urine Organic Acid Test (OAT) is used to take a metabolic snapshot of the body’s functions through the analysis of waste products passed in the urine. Acids present in the urine at certain levels can be indicators of toxicity or even give a reading of how chemical functions are performing at a cellular level. The test can be used to provide markers for inflammation, neurotoxicity,
vitamin D deficiency, bone function, exposure to parabens, mitochondrial dysfunction, beneficial bacteria, glutathione deficiency, yeast overgrowth, and the functioning of the Krebs cycle.

Using The Great Plains Laboratory Urine Organic Test (OAT) is simple. The specimen is sent to The Great Plains Laboratory in a prepaid envelope. All test kits and lab fees are paid through Agape Nutrition, so there’s no need to bill medical insurers. All paperwork can be submitted via the mail or online and results are available between three and four weeks after processing.

    Clostridia Detection


    New Markers: Analyte List


    Quinolinic Acid - Marker for Inflammation and Neurotoxicity!
    Quinolinic acid is an organic acid derived from the amino acid tryptophan and can be neurotoxic at high levels. Excitotoxic substances like quinolinic acid may stimulate nerve cells so much that the nerve cells die. Brain toxicity due to quinolinic acid has been implicated in Alzheimer's disease, autism, Huntington's disease, stroke, dementia from old age, depression, HIV-associated dementia, and schizophrenia.


    Inorganic Phosphate - Marker for Bone Function / Vitamin D Deficiency!
    Low phosphate is associated with hypoparathyroidism, pseudohypoparathyroidism, low nutritional phosphate intake, parathyroidectomy, and vitamin D deficiency.


    4-Hydroxybenzoic Acid - Marker for Exposure to Parabens!
    4-Hydroxybenzoic acid is a metabolite of methylparaben, an anti-fungal agent, and a popular preservative in food and cosmetics. Parabens may be linked to mitochondrial failure due to depletion of cellular ATP through uncoupling of oxidative phosphorylation. They may also be produced from the microbial metabolism of polyphenols in the diet. Parabens have been found at high levels in breast cancer samples, but a definitive relationship with breast cancer has not been demonstrated.


    4-Hydroxyhippuric Acid - Marker for Exposure to Parabens!
    4-Hydroxyhippuric, a glycine conjugate of 4-hydroxybenzoic acid, is a metabolite of methylparaben. This compound is increased from the intake of fruits containing polyphenols rich in anthocyanins, flavonols, and hydroxycinnamates, which are metabolized by gastrointestinal bacteria. 4-Hydroxyhippuric acid has been found to be an inhibitor of Calcium-ATPase in end-stage renal failure.


    Malic Acid - Marker for Mitochondrial Dysfunction!
    When malic acid is simultaneously elevated with citric, fumaric, and alpha-ketoglutaric acids, it strongly suggests cytochrome C oxidase deficiency, indicating dysfunction in the mitochondrial energy pathways.


    DHPPA - Marker for Beneficial Bacteria!

    Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli mediate the breakdown of chlorogenic acid to 3,4-dihydroxy phenyl propionic acid (DHPPA). High values of DHPPA are associated with increased amounts of these bacteria in the gastrointestinal tract.


    N-acetylcysteine (NAC) - Marker for Glutathione Precursor & Chelating Agent!
    N-acetylcysteine is a powerful antioxidant that acts to increase the glutathione reserves in the body. It is found in body fluids but is also used as a nutritional supplement. N-acetylcysteine reduces the toxicity of drugs like acetaminophen (Tylenol) and protects against the toxicity of mercury and other heavy metals. Low levels could indicate a glutathione deficiency.


    Quinolinic Acid / 5-HIAA Ratio - Marker for Neurotoxicity and Inflammation!

    A high ratio of quinolinic acid to the tryptophan metabolite 5-hydroxy indole-acetic acid indicates excessive inflammation due to recurrent infections, excessive tryptophan intake, immune overstimulation, excessive adrenal production of cortisol, or excessive exposure to phthalates.


    Other Important Markers!

    Besides the new markers, the OAT still evaluates other important compounds including the Krebs cycle and neurotransmitters. This reliable test detects the overgrowth of yeast and a bacteria species, Clostridia, commonly missed by conventional culture methods. These organisms and their metabolites can produce or magnify symptoms of many medical conditions. Identification of a yeast or bacterial overgrowth paired with a successful treatment can increase the chance of recovery.


    Yeast: Intestinal growth of yeast & fungi, including Candida, are measured via by-product. High levels indicate an overgrowth.


    Bacterial: Intestinal growth of bacteria, including Clostridia species, is measured via by-product. High levels indicate an overgrowth.


    Oxalates: Elevations may indicate an excess of foods high in oxalates or Vitamin C, digestive disease, B6 deficiency, or intestinal yeast growth. Genetic markers indicate possible hyperoxaluria.


    Glycolysis: Elevations may result from infection, exercise, or B vitamin deficiency. Very high levels may result from genetic metabolic disorders.


    Oxalate Control


    Krebs cycle: Abnormalities may result from nutrient deficiencies, microbial overgrowth, or glutathione (GSH) deficiency.

    2-oxoglutaric: Low levels may result from the regeneration of amino acids to remove excess ammonia.


    Neurotransmitters: Metabolites of dopamine, norepinephrine, adrenaline, and serotonin are measured. Abnormalities may result from stress or poor detoxification, depression, toxic metal exposure, and rarely, specific tumors.


    Pyrimidines: Slight elevations occur from folic acid deficiency. Significant abnormalities can indicate possible genetic dysfunction.


    Fatty acids: Abnormalities can occur from ketogenic diets or fasting, intake of medium-chain triglycerides, carnitine deficiency, or genetic disease.


    Toxic indicators: Abnormalities can occur from deficiency of glutathione, excess ammonia, and aspartame ingestion.


    Vitamin indicators: Abnormalities involving B12, B6, biotin, ascorbic acid are measured. Amino acids: Abnormalities indicate a possible genetic error.


    Miscellaneous: Abnormalities can indicate GI microbial activity or genetic disease.

    • Clinical Usefulness
    • Understand vitamin and hormone metabolism
    • Determine capacity to generate energy
    • Evaluate intestinal wall integrity
    • Assess the performance of the central nervous system
    • Evaluate muscle function
    • Reveal excessive levels of GI yeast
    • Reveal excessive levels of GI bacteria
    • Detect nutritional or antioxidant deficiencies
    • Determine problems in fatty acid metabolism
    • Determine oxalate imbalances


    Depending on test results, follow-up may include:

    • Diet modification
    • Probiotic supplementation
    • Nutritional supplementation
    • Oral anti-fungal or anti-bacterial medications
    • Increase antioxidants
    • Initiate detoxification protocols
    • Follow-up genetic testing

    Sample Test Report: Organic Acid Test (OAT) Sample Report

    NOTE: Due to The Great Plains Laboratory does not have a contract in the state of New York.

     New York residents are not allowed to perform or mail this test kit for processing within or from the state of New York. Furthermore, The Great Plains Laboratory will not process this test kit mailed from the State of New York.

    *If you are interested in performing this test kit, you will need to:

    1. Perform / Collect the specimen outside of the state of New York.
    2. Mail for processing from an address outside of the state of New York.
    3. Receive your results to the same address outside of the state of New York.

    We are sorry for any inconvenience this may cause.


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      USPS First Class Package (1-3 Business Day) UPS Ground (1-7 Business Day)

       Please Note: No Saturday Delivery Available.


      Agape Nutrition is proud to offer:

      United States Postal Service (USPS) and United Parcel Service (UPS) as our standard shipping carriers and their services. Shipping rates are determined in real time or carrier book rate by weight and distance. Shipping Options are determined and reflected upon check out, for your choosing. If an option is not listed upon check out, your package may not meet the weight requirement or the service may not be available to the address location. Automated invoices for orders and shipping updates will drop into the email listed on the Agape Nutrition account. If SMS is accepted, automated updates will go to your phone via text message, you may also receive an email.


      We pride ourselves on providing fast service at competitive prices.

      • Orders received by 12:00 pm Pacific Standard Time (PST) are generally processed the same day, and may ship within 24 hours. However, this is not a guarantee.
      • Orders received after 12:00 PM (PST) may process within 24 to 48 hours of receipt.
      • Tracking is updated within 24 to 48 hours of receipt and after processing and the package has shipped.


      Processing and shipping times are:

      • Estimated and applicable during regular business hours.
      • Dependent upon the daily order volume at Agape Nutrition.
      • Dependent upon the daily order volume at the partner warehouse.
      • Dependent upon the time zones of our manufacture and distributor partners.
      • Dependent upon the shipping service practices and processing standards.


      Signature may be required for:

      • Orders of a high dollar amount.
      • Biotics Research shipments.
      • Vielight shipments.
      • Richway shipments.
      • All electronic devices.
      • All laboratory test kits.


       We have fixed shipping rates for a select few brand partners as per their shipping rate requirements, which may be different then our own and other distributor warehouses. Brands that apply: Vielight, Richway International, Biotics Research.

      Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and / or natural disasters.

      Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Due to no carrier guarantees, delayed or late packages are not eligible for refunds. This is a stipulation directly from the shipping carriers and is out of our control.

      Shipping Service Guarantees Remain Suspended for Most Shipments. Please reach out to the shipping carrier for more information.




      Please see our FAQ page for additional questions and answers.

      All discounts and promotional offers are calculated before shipping and handling rates are applied.


      Orders cannot be cancelled or changed once the order has been placed and the confirmation is received.

      Products may ship faster then expected, and many are automated to process directly after order confirmation. We work directly with top professional manufactures and distributors from across the United States, in all time zones. There are a lot of cogs and wheels turning to process and ship your order efficiently to meet an on time delivery target. When you request a cancellation or change of an order, it may take up to 72 hours to process your request. This process may involve voiding orders in computer systems, removing items from back order logs, pulling items from production schedules and sometimes stopping orders at the shipping dock or warehouse. Our order fulfillment may be performed by many quick hands, in different states and time zones. Therefore, we cannot offer or guarantee order cancellations after the order has been received.

      • Products may process and ship faster then expected.
      • Products may be automated to process directly after the order is confirmed.
      • Product warehouses may be in different states and time zones.
      • Orders may take up to 72 hours to process a cancellation or change. 



      Agape Nutrition is proud to ship to 52 states and territories of the United States.

      • All 50 United States (includes Washington DC, Hawaii, Alaska)
      • Armed Forces: Americas (AA)

      Orders shipped to U.S. military addresses (APO/FPO/DPO) will ship via United States Postal Service (USPS) at the carrier book rate; normal delivery of these orders may be delayed by one (1) business day.


      Agape Nutrition does not offer international shipping at this time, outside the 52 states, including Washington DC and Armed Forces Americas of the United States.


      Products requiring shipment in a cool environment (perishable and frozen items) are subject to special shipping procedures due to their sensitive nature to ensure customers receive products in good condition. Heat sensitive items are shipped using sealed thermal bubble bag, ice pack or brick, resealable bag and extra padding to ensure a cool environment. We do not recommend heat sensitive item ship to territories of the United States, and we cannot be held responsible for cooled environment degradation to these destinations.

      Agape Nutrition recommends that heat sensitive products ship with your preference of any 1-3 Day delivery service. We do not offer overnight or next day delivery service at this time. Saturday delivery is not available or guaranteed, unless offered by the shipping carrier as part of the normal delivery.

      Please Note:

      • Heat sensitive items are not eligible for return, credit, or refund. As we cannot guarantee cool storage or efficacy of the product, after the order has been delivered.
      • Delays in shipping service delivery, caused an issue? See our return policy for further information.



          Please be aware of severe weather and hazardous conditions in your area or other states that may affect the timeliness of your package delivery. Agape Nutrition can not be responsible for severe weather and unforeseen incidents that may impact the processing times and/or shipping services. We will work to ensure the safety of our employees while minimizing effects on service. Contingency plans are in place to help ensure that shipments arrive at their final destinations as quickly as conditions permit.


          Please Be Aware of Any Possible Shipping Delays:

          (1) Slight delays with fulfillment processing may occur as manufacture and distributor warehouses are experiencing higher than normal volume and demand for nutritional items.

          (2) Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and/or natural disasters. Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Please reach out to the shipping carrier for more information.

          (3) Please be aware of severe weather conditions in or around your location and surrounding states that my affect the timeliness of delivery.

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