Metagenics SPM Active®
Concentrated specialized pro-resolving mediators (SPMs) from omega-3 fish oil, pre-converted so your body can put them to work fast, to help ease everyday soreness and support joint comfort.*
- ✓ Targets soreness at the source, not just the symptoms.*
- ✓ 36% felt less sore in 2 weeks; 81% less joint discomfort at 3 months.*†
- ✓ Pre-converted SPMs, no conversion step like ordinary fish oil. Friend of the Sea certified.
†Based on loading dose with 2g SPM Active daily for 6 weeks.
Choose your size here. You'll confirm it on Metagenics.
Agape Nutrition is an authorized Metagenics partner. Your purchase completes on the official Metagenics store. The link opens the Metagenics storefront. Search "SPM Active" there, choose 60 or 120 softgels, and the 15% first-order discount and free shipping apply automatically at the Metagenics checkout.
- ✓ Official authorized Metagenics partner
- ✓ Metagenics 60-Day Satisfaction Guarantee
- ✓ #1 doctor-recommended professional supplement brand
- ✓ Friend of the Sea certified · Non-GMO · Gluten-Free
- ✓ Purchase completes securely on metagenics.com
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The soreness that lingers a little longer than it used to
You move, you ache, and lately the ache hangs around.
Everyday soreness is normal. Soreness that overstays its welcome, after a workout, a long day, or just another birthday, is the part that wears on you. There is a reason it creeps up with age. Your body makes its own specialized pro-resolving mediators (SPMs), natural compounds that help it ease soreness and recover. As we get older, our SPM levels drop, and that is when muscle and joint discomfort start to add up.*
Most people reach for something that masks the feeling. SPM Active takes a different route. It helps your body do what it already knows how to do: resolve soreness rather than simply cover it up.*
36% of people felt less sore in 2 weeks, and 81% reported less joint discomfort at 3 months.*† SPM Active comes from Metagenics, the #1 doctor-recommended professional supplement brand, trusted by more than 50,000 healthcare practitioners.
†Based on loading dose with 2g SPM Active daily for 6 weeks.
What "just push through it" actually costs
Masking the feeling is not the same as resolving it.
- You start skipping things. The walk, the workout, the game on the floor with the kids. Soreness quietly shrinks what you say yes to.
- "Normal aches" pile up. One stiff knee becomes a stiff knee and a sore shoulder. Treated as background noise, they compound.
- Ordinary fish oil makes your body do the work. Standard EPA/DHA omega-3s still have to be converted by your body before they can help resolve soreness. That conversion slows with age, exactly when you need it most.*
- Masking is not resolving. Covering the signal can get you through the day, but it does nothing for the underlying recovery your body is trying to complete.*
SPM Active: the recovery step your body is missing
Get back to feeling like yourself.
SPM Active delivers specialized pro-resolving mediators (SPMs): concentrated nutrients from omega-3 fish oil that target the root causes of soreness, not just the symptoms.* Whether it is joint discomfort, post-exercise recovery, or everyday aches, it helps your body bounce back so you can keep moving freely.*
The difference is that these SPMs come pre-converted. Where ordinary fish oil supplies EPA and DHA that your body still has to transform, SPM Active delivers the bioactive mediators directly, so it can support your natural inflammation resolution pathways more efficiently.* Clinical research showed a decrease in joint soreness and discomfort intensity in 2 weeks.*† Individual results vary.
†Based on loading dose with 2g SPM Active daily for 6 weeks.
Why SPM Active works
Most soreness products work by quieting the signal. They mask what you feel. SPM Active takes a different approach. It supports the part of your biology that is supposed to bring soreness to a close on its own.*
What SPMs actually are. SPM stands for specialized pro-resolving mediators. These are natural compounds your body makes from omega-3 fatty acids, and they run the resolution phase of your body's normal response to physical stress. Think of it as two halves of one process. The first half ramps things up after exercise, strain, or daily wear. The second half, resolution, is what winds it back down and clears the way for recovery. SPMs are the signals that drive that second half.* This is why we say SPM Active supports your body's natural inflammation resolution pathways, the body's own clean-up and recovery system, rather than simply masking symptoms.*
Why this matters as you age. Your body naturally produces SPMs to help ease soreness and support recovery. But as we age, SPM levels drop, and that is when everyday muscle and joint discomfort start to add up.* SPM Active gives your body more of what it already uses, sourced and concentrated from omega-3 fish oil.*
"SPM Active skips the line. It delivers specialized pro-resolving mediators that are already pre-converted.*"
Pre-converted is the whole point. Here is the difference between SPM Active and a standard EPA/DHA fish oil. Regular fish oil delivers the raw omega-3 building blocks, and your body then has to convert them, through several enzymatic steps, into the active resolution compounds. That conversion is not always efficient, and it tends to slow with age and metabolic stress. SPM Active skips the line. It delivers specialized pro-resolving mediators that are already pre-converted, so they do not require the same metabolic conversion as traditional fish oil.* That is what lets it support the body's resolution pathways more efficiently and target soreness at the source, not just the symptoms.*
Standardized so you know what you are getting. Each serving provides 1 gram of Active Fractionated Marine Lipid Concentrate, with the SPM content standardized to three specific markers: 18-HEPE (18-hydroxy-eicosapentaenoic acid), 17-HDHA (17-hydroxy-docosahexaenoic acid), and 14-HDHA (14-hydroxy-docosahexaenoic acid). Those are the precursors and pathway markers of the resolution system. Standardizing to them is how Metagenics confirms that what is on the label is what is in the softgel, batch after batch.
Individual results vary. SPM Active is a dietary supplement, not a medication, and if you are pregnant, nursing, or taking medication, talk with your healthcare practitioner before adding it.
SPMs, the resolution signal
Natural compounds that help your body ease soreness and support lasting joint health.*
Standardized markers
Standardized to 18-HEPE, 17-HDHA, and 14-HDHA in a 1 g Active Fractionated Marine Lipid Concentrate.
Pre-converted
No EPA/DHA conversion step, unlike ordinary fish oil.*
Fast to work with
Designed to be absorbed in 15 minutes.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
SPM Active vs. standard EPA/DHA fish oil
Both come from omega-3s. They do different jobs.
| SPM Active | Standard EPA/DHA fish oil | |
|---|---|---|
| What it delivers | Pre-converted SPMs (18-HEPE, 17-HDHA, 14-HDHA) | EPA and DHA, the raw building blocks |
| Conversion needed by your body | No, delivered bioactive* | Yes, your body must convert it first* |
| Primary role | Targeted: helps resolve soreness and joint discomfort* | Foundational omega-3 wellness support |
| Designed for | Recovery and everyday soreness* | General health |
| Dose | 2 softgels once daily | Often multiple large softgels |
| Certification | Friend of the Sea | Varies |
Regular fish oil is great foundational support. SPM Active is the targeted tool for soreness and recovery.*
See why people switched from ordinary fish oil
Get SPM Active on Metagenics →Purchase completes on the official Metagenics store. 15% off your first order plus free shipping, auto-applied at checkout.
What is in every 2-softgel serving
One concentrated active, responsibly sourced. Supplement Facts panel shown alongside.
The SPM source, standardized to 18-HEPE, 17-HDHA, and 14-HDHA.
Fish oil from anchovy, sardine, and mackerel, with mixed tocopherols as a natural antioxidant.
Gelatin, glycerin, and water. Plus silica.
Per serving: 10 calories, 1 g fat, less than 5 mg cholesterol.
Other ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, and mackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin, and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).
One concentrated active, standardized and certified
Get SPM Active on Metagenics →You will finish your purchase on the official Metagenics store. New customers get 15% off plus free shipping, auto-applied at checkout.
How to take SPM Active, and what to expect
Take two softgels once daily or as directed by your healthcare practitioner.
Take two softgels once daily, or as directed by your healthcare practitioner. The softgels are designed to be absorbed efficiently, and they can be taken with or without food. Many people find it easiest to take them with a meal.
SPMs work best taken consistently, the way you would take any foundational support. This is not a single-dose painkiller and it is not meant to be. It is daily support for your body's own recovery system.* Individual results vary.
- Contains: Fish (anchovy, sardine, and mackerel). Do not use if you have a fish allergy.
- If you are pregnant, nursing, or taking medication, consult your healthcare practitioner before use. Keep out of the reach of children.
- If you take blood-thinning medication, talk with your healthcare practitioner before use, because omega-3-derived products can be relevant to your care. Do not start or stop any prescription on your own.
- Store in a dry place.
†Based on loading dose with 2g SPM Active daily for 6 weeks.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Real people, real relief
Verified 5-star reviews from the Metagenics product page.
Two real customers, in their own words. Individual results vary, and consistent daily use delivers the best outcomes.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Join the 77% who felt less joint discomfort after a month†
Get SPM Active on Metagenics →Completes on the official Metagenics store. 15% off your first order plus free shipping, auto-applied. †Based on loading dose with 2g SPM Active daily for 6 weeks.
Love it within 60 days or your money back
The Metagenics 60-Day Satisfaction Guarantee, honored where you check out.
Every purchase through the official Metagenics store is backed by the Metagenics 60-Day Satisfaction Guarantee. In their words: love it within 60 days or your money back. Because you complete checkout on the Metagenics store, their guarantee applies directly to your order, with no separate Agape claim to file.
New to Metagenics? You also start with 15% off your first order plus free shipping, auto-applied at checkout.
Agape Nutrition is an authorized Metagenics partner. We do not process this order or issue refunds for it. The Metagenics 60-Day Satisfaction Guarantee is honored by Metagenics on their store.
60 days to feel the difference. Love it or get your money back.
Get SPM Active on Metagenics →Backed by the Metagenics 60-Day Satisfaction Guarantee. New customers get 15% off plus free shipping, auto-applied at the Metagenics checkout.
4.48 out of 5, and recommended by doctors
Verified customer ratings plus the practitioner numbers behind them.
On metagenics.com, SPM Active averages ★4.48 out of 5 from 54 reviews. And it is not just customers: in a Metagenics survey of doctors, 93% recommend it for joint discomfort, and 96% said it eased minor pain and improved joint mobility.†† That combination, real customers plus practitioner confidence, is the case for trying it. Individual results vary.
††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.
★ 4.48 from 54 real reviews on metagenics.com
Get SPM Active on Metagenics →Purchase completes on the official Metagenics store. 15% off your first order plus free shipping, auto-applied.
Questions, answered
How is SPM Active different from regular fish oil?
How fast does it work?
Is it safe to take every day?
I have a fish allergy. Can I take this?
Can I take it with my medications?
How does buying through the Metagenics store work?
Does the 15% off and free shipping offer apply?
Should I get the 60 or the 120 count?
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Still have questions? Try it for 60 days with nothing to lose
Get SPM Active on Metagenics →You will complete your purchase on the official Metagenics store, backed by their 60-Day Satisfaction Guarantee. New customers get 15% off plus free shipping, auto-applied.
References and substantiation
The science behind SPM Active centers on specialized pro-resolving mediators (SPMs), the family of compounds your body derives from omega-3 fatty acids to drive the resolution phase of its normal recovery response. The primary clinical reference for this product, plus supporting SPM literature, is below. These references are provided for education and do not constitute claims that this product treats, cures, or prevents any disease.
- Callan N, Hanes D, Bradley R. Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain. J Transl Med. 2020;18(1):401. doi:10.1186/s12967-020-02569-5.
- Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014;510(7503):92-101. doi:10.1038/nature13479.
- Serhan CN, Chiang N, Dalli J. The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015;27(3):200-215. doi:10.1016/j.smim.2015.03.004.
- Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017;45(5):1105-1115. doi:10.1042/BST20160474.
- Schwanke RC, Marcon R, Bento AF, Calixto JB. EPA- and DHA-derived resolvins' actions in inflammatory bowel disease. Eur J Pharmacol. 2016;785:156-164. doi:10.1016/j.ejphar.2015.08.050.
†Based on loading dose with 2g SPM Active daily for 6 weeks.
††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Round out your recovery routine
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
