Metagenics UltraGI Replenish®
A practitioner-grade medical food for people whose gut no longer absorbs what it should, built around 2 g of a breast-milk-type prebiotic to help replenish the intestinal lining and feed a healthy microbiota.
- ✓ Engineered for compromised gut function and malabsorption, not a standard protein shake.
- ✓ 12 g easy-to-absorb dual-source protein, 7 g fiber, and 28 vitamins and minerals per serving.
- ✓ 2 g of 2'-Fucosyllactose (PreBiome 2'-FL™, patented by Metagenics), a prebiotic similar to one found in breast milk.
Choose your flavor and size here. You'll confirm it on Metagenics.
Agape Nutrition is an authorized Metagenics partner. Your purchase completes on the official Metagenics store. The link opens the Metagenics storefront. Search "UltraGI Replenish" there, choose your flavor and size, and the 15% first-order discount and free shipping apply automatically at the Metagenics checkout.
- ✓ Official authorized Metagenics partner
- ✓ Metagenics 60-Day Satisfaction Guarantee
- ✓ #1 doctor-recommended professional supplement brand
- ✓ Purchase completes securely on metagenics.com
2 scoops twice daily in chilled water. Medical food, use under practitioner supervision.
When your gut stops absorbing, eating well is not enough
You can do everything right at the table and still come up short.
Compromised gut function changes the math. When the intestinal lining is inflamed or damaged, food can pass through without being fully absorbed. People eat real meals and still lose weight they did not mean to lose. They feel tired in a way that rest does not fix. Bloodwork starts flagging low iron, low B12, low vitamin D, the quiet deficiencies that build when nutrients are not making it across the gut wall.
This is the gap a regular diet cannot close on its own. It is also why UltraGI Replenish is classified as a medical food rather than a wellness shake. It is formulated for the increased nutritional needs that come with malabsorption and compromised gut function, and it is meant to be used under the supervision of your healthcare practitioner.
Trusted by more than 50,000 healthcare practitioners. Metagenics is the #1 doctor-recommended professional supplement brand, with 40+ years of formulation and over 200,000 quality tests run every year.
Why the deficit keeps widening
Left unaddressed, compromised absorption tends to compound.
- Deficiencies stack. When absorption is impaired, low iron, B12, zinc, and vitamin D rarely arrive alone. One shortfall pulls energy, immunity, and recovery down with it.
- Restricted diets shrink the margin further. Many people managing GI conditions are already cutting out foods. Fewer inputs plus poor absorption leaves very little room for error.
- Standard shakes were not built for this. Most protein powders and meal replacements assume a healthy gut. They are not designed around the absorption and tolerability needs of a compromised one.
- Guessing is risky here. This is exactly the situation where self-directed nutrition can go sideways, and exactly why this product is used under practitioner supervision.
If you've been struggling and nothing else is working, this is the last resort.
PreBiome 2'-FL™, patented by Metagenics. 2 grams in every serving.
A medical food built for the gut that needs the most help
UltraGI Replenish meets the increased nutritional needs of those with compromised gut function.
This is not a fortified smoothie. UltraGI Replenish is an advanced-formula medical food designed for the specific demands of compromised digestion and malabsorption. Every serving delivers 12 g of easy-to-absorb protein from a dual pea-and-rice source with a full amino acid profile, 7 g of fiber, healthy fats, and 28 vitamins and minerals, several at clinically meaningful levels including 100% of the RDI for zinc and activated forms of B12 and folate.
At its center is PreBiome 2'-FL™, 2 g of a prebiotic similar to one found in breast milk. The formula is built to support digestion and nutrient absorption, help replenish the intestinal lining, and promote a healthy gut microbiota. It comes in Chocolate and Vanilla, mixes into 8 ounces of chilled water, and is taken twice daily or as directed by your practitioner. Individual results vary.
Why UltraGI Replenish works
When the gut is compromised, the problem is rarely that you are not eating enough. The problem is that your gut has lost the ability to break food down and absorb it. You can eat a full plate and still come up short on protein, vitamins, and minerals, because the lining that is supposed to do the absorbing is inflamed, thinned, or simply not working the way it should. This is what we call malabsorption, and it is exactly the situation UltraGI Replenish was built for.
It rebuilds the surface that does the absorbing. Your intestinal lining is a single layer of cells held together by tight junctions, the microscopic seals that decide what gets into your bloodstream and what stays out. When that lining is damaged, two things happen at once: nutrients you need do not get in, and particles that should stay out can slip through. UltraGI Replenish supplies targeted nutrients, including L-alanyl-L-glutamine, that the cells of the intestinal lining use as fuel, so the surface that does the absorbing has what it needs to recover.
"A probiotic adds bacteria; a prebiotic feeds the ones that belong there."
It feeds the right bacteria with a prebiotic similar to one found in breast milk. The hero of this formula is 2'-fucosyllactose, or 2'-FL, delivered at 2 grams per serving. 2'-FL is a human-milk-oligosaccharide-type prebiotic, the same family of compounds an infant receives from breast milk to establish a healthy gut from day one. Here is the key idea about prebiotics: your body does not digest them. Your good bacteria do. 2'-FL passes through to the colon intact and selectively feeds beneficial species, helping shift the microbiota back toward balance and supporting a healthier intestinal environment. This is why a prebiotic, not just a probiotic, matters for a compromised gut. A probiotic adds bacteria; a prebiotic feeds the ones that belong there.
It delivers nutrition in forms a struggling gut can actually use. A compromised gut cannot afford to work hard for its nutrition. So this formula is built to be gentle and bioavailable: 12 grams of dual-source protein from pea and rice with a complete amino acid profile including the branched-chain amino acids, plus 28 vitamins and minerals in their more usable forms, including activated B12 as methylcobalamin and folate as L-5-methyltetrahydrofolate rather than synthetic folic acid, and minerals in chelated forms for absorption. The point is not just what is in the can. It is whether a struggling gut can take it up. This formula is designed so it can.
Put the three together, replenish the lining, feed the right microbiota, and deliver absorbable nutrition, and you support the gut's own ability to do its job. Individual results vary, and because this is a medical food, it is meant to be used under the supervision of your physician or healthcare practitioner.
2'-FL (PreBiome 2'-FL™), 2 g
Breast-milk-type prebiotic to help replenish the intestinal lining and promote a healthy microbiota.
L-Alanyl-L-Glutamine, 500 mg
Fuel for the cells lining the gut.
Dual-source protein, 12 g
Pea plus rice, complete amino profile including BCAAs.
Activated micronutrients
Methylcobalamin B12 and methylfolate, plus 100% RDI zinc.
See how UltraGI Replenish supports a compromised gut
A short overview of what this medical food does and who it is built for.
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Why a medical food, and not a protein shake or a multivitamin
Same shelf, very different job.
| UltraGI Replenish | Standard protein shake | Regular multivitamin | |
|---|---|---|---|
| Designed for compromised gut function | Yes, it is a medical food for this purpose | No, assumes a healthy gut | No |
| Breast-milk-type prebiotic (2'-FL) | 2 g PreBiome 2'-FL™ | Rarely, if ever | No |
| Protein for rebuilding | 12 g dual-source, absorbable | Often, but not gut-targeted | None |
| Broad micronutrient support | 28 vitamins and minerals, activated forms | Minimal | Yes, but no protein, fiber, or prebiotic |
| Intended use | Under practitioner supervision | General | General |
This is not a knock on protein powders or multivitamins. They are built for different people. UltraGI Replenish is built for the gut that needs the most help.
See why practitioners reach for a medical food, not a shake
Get UltraGI Replenish on Metagenics →Purchase completes on the official Metagenics store. 15% off your first order plus free shipping, auto-applied at checkout.
What is in every 2-scoop serving
Dosed, sourced, and listed in full. Supplement Facts panel shown alongside.
PreBiome 2'-FL™, a patented breast-milk-type prebiotic. The hero. Helps replenish the intestinal lining and feed a healthy microbiota.
Additional prebiotic fiber.
Pea protein isolate plus rice protein concentrate. Complete amino profile including the BCAAs leucine, isoleucine, and valine.
Glutamine source, fuel for intestinal cells.
Plant omega-3.
Including zinc 11.2 mg (100% RDI), chromium 340% RDI, biotin 250% RDI, copper 170% RDI, plus activated B12 (methylcobalamin) and methylfolate.
Other ingredients: Pea protein isolate, bamboo fiber, isomalto-oligosaccharide, rice protein concentrate, 2'-fucosyllactose powder, gum acacia, flaxseed, olive oil, L-lysine HCl, L-leucine, medium-chain triglycerides, silica, L-valine, L-alanyl-L-glutamine, L-isoleucine, xanthan gum, vitamin and mineral blend, natural flavor, and Luo Han Guo fruit (monk fruit) extract.
Allergen pointer: contains pea protein, rice protein, and flaxseed; see full ingredient list.
Non-GMOEvery ingredient disclosed and dosed. Nothing hidden.
Get UltraGI Replenish on Metagenics →You will finish your purchase on the official Metagenics store. New customers get 15% off plus free shipping, auto-applied at checkout.
How to take UltraGI Replenish
Blend, shake, or briskly stir 2 level scoops (45 grams) into 8 fluid ounces of chilled water. Take twice daily, or as directed by your healthcare practitioner.
- Use chilled water and mix well. Cold water and a shaker bottle or blender give the smoothest texture and the best flavor (available in Chocolate and Vanilla).
- Two servings a day is the design. This is a nutritional foundation, not a one-off shake. Consistency is what lets the lining and the microbiota respond over time.
- Work it into your day. Many people use one serving in the morning and one later in the day. Your practitioner may tailor the timing to your needs.
- It is a medical food, so it is meant to be supervised. Your practitioner can tell you how it fits alongside the rest of your nutrition and any other care you are receiving.
- UltraGI Replenish is a medical food for the dietary management of compromised gut function and malabsorption. It is intended to be used with the involvement of your healthcare practitioner.
- This product contains pea protein, rice protein, and flaxseed. See the full ingredient list before use if you have known food sensitivities.
- Keep out of the reach of children. Store in a dry place.
Rated 4.56 out of 5, and chosen by the practitioners who manage these conditions
For a medical food, practitioner confidence is the social proof that matters. Here are the numbers.
UltraGI Replenish holds a ★4.56 out of 5 average across 73 reviews on metagenics.com. More telling for a medical food: it comes from the brand more than 50,000 healthcare practitioners trust, the #1 doctor-recommended professional supplement brand. For a product used under supervision, the practitioner's confidence is the social proof that matters most.
Rated 4.56 out of 5 by 73 reviewers and trusted by 50,000+ practitioners
Get UltraGI Replenish on Metagenics →Completes on the official Metagenics store. 15% off your first order plus free shipping, auto-applied.
Backed by the Metagenics 60-Day Satisfaction Guarantee
Because your purchase happens on Metagenics, their guarantee is the one that protects you.
Every purchase through the official Metagenics store is covered by the Metagenics 60-Day Satisfaction Guarantee. If you are not satisfied within 60 days, Metagenics stands behind it. You complete checkout on their store, so their policy applies directly to your order, no middleman, no separate Agape claim to file.
And if you are new to Metagenics, you start with 15% off your first order plus free shipping, auto-applied at checkout.
Agape Nutrition is an authorized Metagenics partner. We do not process this order or issue refunds for it. The Metagenics 60-Day Satisfaction Guarantee is honored by Metagenics on their store.
60 days to decide. If it is not for you, Metagenics has you covered.
Get UltraGI Replenish on Metagenics →Backed by the Metagenics 60-Day Satisfaction Guarantee. New customers get 15% off plus free shipping, auto-applied at the Metagenics checkout.
4.56 out of 5 across 73 reviews
Verified ratings from the official Metagenics product page, alongside the credentials behind the brand.
On metagenics.com, UltraGI Replenish averages ★4.56 out of 5 from 73 reviews. Those ratings sit on top of a brand built for accountability: more than 50,000 healthcare practitioners trust Metagenics, the formula is produced in GMP-certified facilities, and the company runs over 200,000 quality tests a year to verify that what is on the label is what is in the pouch. Individual results vary.
★ 4.56 from 73 real reviews on metagenics.com
Get UltraGI Replenish on Metagenics →Purchase completes on the official Metagenics store. 15% off your first order plus free shipping, auto-applied.
Questions, answered
Is UltraGI Replenish a supplement or something different?
Do I need a prescription?
Who is this for, and who should not use it?
How long until I notice a difference?
Are there interactions or anything I should watch for?
How does buying through the Metagenics store work?
Does the 15% off and free shipping offer apply?
What flavors and sizes are there, and what do they cost?
How do I take it?
Still deciding? Talk to your practitioner, then start when you are ready
Get UltraGI Replenish on Metagenics →You will complete your purchase on the official Metagenics store, backed by their 60-Day Satisfaction Guarantee. New customers get 15% off plus free shipping, auto-applied.
References and substantiation
The science behind UltraGI Replenish centers on 2'-fucosyllactose (2'-FL), a human-milk-oligosaccharide (HMO)-type prebiotic, and on the role of the intestinal barrier in nutrient absorption. The following references support the mechanisms described on this page. They are provided for education and do not constitute claims that this product treats, cures, or prevents any disease.
- Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012;22(9):1147-1162. doi:10.1093/glycob/cws074.
- Vandenplas Y, Berger B, Carnielli VP, et al. Human Milk Oligosaccharides: 2'-Fucosyllactose (2'-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula. Nutrients. 2018;10(9):1161. doi:10.3390/nu10091161.
- Šuligoj T, Vigsnæs LK, Abbeele PVden, et al. Effects of Human Milk Oligosaccharides on the Adult Gut Microbiota and Barrier Function. Nutrients. 2020;12(9):2808. doi:10.3390/nu12092808.
- Natividad JM, Rytz A, Keddani S, et al. Blends of Human Milk Oligosaccharides Modulate Intestinal Inflammation. Cells. 2022;11(17):2664. doi:10.3390/cells11172664.
- Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017;18(5):1051. doi:10.3390/ijms18051051.
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