Allergy Research Group, TMG Trimethylglycine 100 VegiCaps

Trimethylglycine (TMG) supports methylation, liver health, and homocysteine metabolism, and acts as a cellular osmolyte for stress resilience.* TMG assists in the metabolism of homocysteine to methionine, resulting in the production of DMG (dimethylglycine).* The two major functions of TMG in humans are as an osmolyte to protect cells under stress and as a methyl-group donor.*

Supports Healthy Methylation and Cellular Resilience*

What It Does

Trimethylglycine (TMG), also known as betaine, supports normal homocysteine metabolism and helps maintain healthy methylation pathways. It supports liver and kidney cell health, promotes osmotic balance, and protects cellular structures under stress.*

How It Works

• Trimethylglycine (TMG): provides methyl groups to convert homocysteine to methionine via the enzyme betaine homocysteine methyltransferase (BHMT), especially active in the liver and kidneys.*[1]
  
• Bypasses MTHFR limitations: offering an alternative methylation route for individuals with the 677TT polymorphism or functional folate needs.*[2]
  
• Supports healthy homocysteine metabolism.*[3-4]
  
• Effective at lower doses, with benefits observed at lower dietary intake levels of betaine.*[5]
  
• Acts as a cellular osmolyte protecting proteins, enzymes, and DNA while improving cellular fluid retention and resilience to osmotic stress which is particularly supportive for kidney cells.*[6][2]
  

Who It’s For

Ideal for individuals seeking to support cardiovascular and liver health, methylation balance, or homocysteine support, especially those with genetic polymorphisms affecting folate metabolism.*

Special Features

Offers dual-action support for methylation and cellular osmoprotection, making it uniquely valuable for stress-prone tissues like the liver and kidneys.*

Supplement Facts

Serving Size: 1 capsule
Servings Per Container: 100

Amount per Serving

Trimethylglycine: 750 mg

Other Ingredients

Hydroxypropyl methylcellulose, rice concentrate, silicon dioxide.

Suggested Use

As a dietary supplement, take 1 capsule twice daily before meals, or as directed by a healthcare practitioner.

Warning

If you are pregnant or lactating, have any health condition, or are taking any medication, consult your healthcare practitioner before use.

Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if the safety seal is intact. Variations in product color may occur.

References

1. Obeid R. Nutrients. 2013;5(9):3481–95.
2. Arumugam MK et al. Biology. 2021;10(6):456. doi:10.3390/biology10060456
3. Steenge GR et al. J Nutr. 2003;133(5):1291–5.
4. McRae MP. J Chiropr Med. 2013;12(1):20–5.
5. Olthof MR et al. J Nutr. 2003;133(12):4135–8.
6. Craig S. Am J Clin Nutr. 2004;80(3):539–49