Bioclinic Naturals, Magnesium Bisglycinate 5.1 oz

Benefits

• Magnesium bisglycinate form is more easily absorbed than salt forms such as magnesium oxide1
• Bisglycinate chelated form is less likely to cause laxative effects than salt forms1,2
• Powder form allows for easy and convenient dosing away from food
• Non-GMO and suitable for vegetarians/vegans
• Sugar-free with a pleasant taste from citric acid

Feature Summary

Magnesium helps maintain proper muscle function. It also supports metabolism, the ability to derive energy from proteins, carbohydrates, and fat.3 Magnesium helps normalize blood pressure and fasting plasma glucose,4 improves insulin sensitivity and decreases the risk of developing diabetes mellitus type 2,5 along with reducing blood pressure, hyperglycemia, and triglycerides in metabolic syndrome.6 Magnesium needs can be increased by stress, an unbalanced diet, coffee, and alcohol consumption,7, and certain medications such as proton-pump inhibitors.8 As a result, it can be difficult to meet the body’s daily magnesium needs through diet alone.9

In a randomized, controlled trial, healthy older women were assigned to the treatment group receiving 300 mg of magnesium daily or to a control group. After 12 weeks, the treatment group had significant improvements in physical performance compared to the control group. The authors concluded that supplementation may have a role in preventing age-related physical decline.10 A double-blind, placebo-controlled trial found that supplementation with 300 mg of magnesium bisglycinate daily for four weeks decreased the frequency and intensity of pregnancy-induced leg cramps.11 Magnesium is an important factor in muscle mass and repair and has been shown to relieve muscle cramps of various causes.12

Supplement Facts

Serving Size: 1 Scoop (2.4 g)

Servings Per Container: 50

Non-Medicinal Ingredients

Citric acid.

Dosage

1 serving (2.9 g) per day or as directed by a health care practitioner. Mix well in 250 ml of water until fully dissolved.

Warnings

Keep out of the reach of children. Individuals with impaired renal function should use this product under medical supervision to monitor the potential for hypermagnesemia.15

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Drug Interactions

Individuals with impaired renal function should use this product under medical supervision to monitor the potential for hypermagnesemia. When taken together, magnesium can decrease the absorption of levodopa/carbidopa,16 quinolone antibiotics,17 tetracycline antibiotics,18 and can increase the absorption of sulfonylureas.19 Magnesium levels may be depleted by aminoglycoside antibiotics,20 amphotericin B,21 cyclosporine,22 digoxin,23 potassium-wasting diuretics,24 oral contraceptives,25 foscarnet,26 sodium phosphates,27 tacrolimus,28 and proton-pump inhibitors.9

References

1. Schuette, S.A., Lashner, B A., & Janghorbani, M. (1994). Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. Journal of Parenteral and Enteral Nutrition, 18(5), 430-435.
2. Siebrecht, S. (2013). Magnesium bisglycinate as safe form for mineral supplementation in human nutrition. OM & Ernahrung, 144.
3. Jahnen-Dechent, W., & Ketteler, M. (2012). Magnesium basics. Clinical Kidney Journal, 5(Suppl 1), i3-i14.
4.  Verma, H., & Garg, R. (2017). Effect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta-analysis. Journal of Human Nutrition and Dietetics: The Official Journal of the British Dietetic Association, 30(5), 621-633.
5. Veronese, N., Watutantrige-Fernando, S., Luchini, C., et al. (2016). Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials. European Journal of Clinical Nutrition, 70(12), 1354-1359.
6. Rodríguez-Morán, M., Simental-Mendía, L.E., Gamboa-Gómez, C.I., et al. (2018). Oral magnesium supplementation and metabolic syndrome: a randomized double-blind placebo-controlled clinical trial. Advances in Chronic Kidney Disease, 25(3), 261-266.
7. Nechifor, M. (2018). Magnesium in addiction - a general view. Magnesium Research, 31(3), 90-98.
8. Turnock, M., Pagnoux, C., & Shore, K. (2014). Severe hypomagnesemia and electrolyte disturbances induced by proton pump inhibitors. Journal of Digestive Diseases, 15(8), 459-462.
9. Health Canada. (2020). Do Canadian adults meet their nutrient requirements through food intake alone? Canada.ca. Retrieved from https://www.canada.ca/en/health-canada/services/food-nutrition/food-nutrition-surveillance/health-nutrition-surveys/canadian-community-health-survey-cchs/canadian-adults-meet-their-nutrient-requirements-through-food-intake-alone-health-canada-2012.html.
10. Veronese, N., Berton, L., Carraro, S., et al. (2014). Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. American Journal of Clinical Nutrition, 100(3), 974-981.
11. Supakatisant C., & Phupong V. (2015). Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Maternal & Child Nutrition, 11(2):139-145.
12. Welch, A.A., Kelaiditi, E., Jennings, A., et al. (2016). Dietary magnesium is positively associated with skeletal muscle power and indices of muscle mass and may attenuate the association between circulating C-reactive protein and muscle mass in women. Journal of Bone and Mineral Research, 31(2), 317-325.
13. ELDerawi, W.A., Naser, I.A., Taleb, M.H., et al. (2018). The Effects of oral magnesium supplementation on glycemic response among type 2 diabetes patients. Nutrients, 11(1), 44.
14. Rajizadeh, A., Mozaffari-Khosravi, H., Yassini-Ardakani, M., et al. (2017). Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial. Nutrition (Burbank, Los Angeles County, Calif.), 35, 56-60.
15. Van Laecke, S. (2019). Hypomagnesemia and hypermagnesemia. Acta Clinica Belgica, 74(1), 41-47.
16. Kashihara, Y., Terao, Y., Yoda, K., et al. (2019). Effects of magnesium oxide on the pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation. European Journal of Clinical Pharmacology, 3, 351.
17. Imaoka, A., Hattori, M., Akiyoshi, T., et al. (2014). The decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption. Drug Metabolism and Pharmacokinetics, 29(5), 414-418.
18. Sompolinsky, D., & Samra, Z. (1972). Influence of magnesium and manganese on some biological and physical properties of tetracycline. Journal of Bacteriology, 110(2), 468-476.
19. Neuvonen, P., & Kivisto, K. (1991). The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations. British Journal of Clinical Pharmacology, 32(2), 215.
20. L'Hommedieu, C.S., Nicholas, D., Armes, D.A., et al. (1983). Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin. The Journal of Pediatrics, 102(4), 629-631.
21. Karimzadeh, I., Heydari, M., Ramzi, M., et al. (2016). Frequency and associated factors of amphotericin b nephrotoxicity in hospitalized patients in hematology-oncology wards in the southwest of Iran. Nephro-Urology Monthly, 8(5), e39581.
22. Thompson, C.B., June, C.H., Sullivan, K.M., et al. (1984). Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet, 2(8412), 1116-1120.
23. Gottlieb, S.S., Baruch, L., Kukin, M.L., et al. (1990). Prognostic importance of the serum magnesium concentration in patients with congestive heart failure. Journal of the American College of Cardiology, 16(4), 827.
24. Dyckner, T., Wester, P.O., & Widman, L. (1988). Effects of per oral magnesium on plasma and skeletal muscle electrolytes patients on long-term diuretic therapy. International Journal of Cardiology, 19(1), 81-87.
25. Palmery, M., Saraceno, A., Vaiarelli, G., et al. (2013). Oral contraceptives and changes in nutritional requirements. European Review for Medical and Pharmacological Sciences, 17(13), 1804-1813.
26. Huycke, M.M., Naguib, M.T., Stroemmel, M.M., et al. (2000). A double-blind placebo-controlled crossover trial of intravenous magnesium sulfate for foscarnet-induced ionized hypocalcemia and hypomagnesemia in patients with AIDS and cytomegalovirus infection. Antimicrobial Agents and Chemotherapy, 44(8), 2143-2148.
27. Shaoul, R., Wolff, R., Seligmann, H., et al. (2001). Symptoms of hyperphosphatemia, hypocalcemia, and hypomagnesemia in an adolescent after the oral administration of sodium phosphate in preparation for a colonoscopy. Gastrointestinal Endoscopy, 53(6), 650-652. 
28. Gratreak, B.D.K., Swanson, E.A., Lazelle, R.A., et al. (2020). Tacrolimus-induced hypomagnesemia and hypercalciuria require FKBP12 suggesting a role for calcineurin. Physiological Reports, 8(1), e14316.