Bioclinic Naturals, Probiotic-Pro BB536® 60 Veg Capsules

Benefits

• High potency: 10 billion cfu (colony forming unites) of Bifidobacterium longum BB536 per capsule
• Superior shelf stability when compared to other species of Bifidobacterium
• BB536 is one of the most studied species in the world
• Resistance to gastrointestinal (GI) acidity allows the formula to reach the large intestine1,2
• Stable at room temperature; refrigeration not required
• Suitable for vegetarians/vegans

Feature Summary

Probiotic-Pro BB536 is a high-potency probiotic containing 10 billion CFUs per capsule of the species Bifidobacterium longum BB536, one of the most researched in the world. It is a proprietary strain with a remarkably longer and more stable shelf life than other probiotic supplements, demonstrating a lower loss rate than other strains of Bifidobacterium exposed to multiple different temperatures.1

Isolated from healthy human GI tracts, Bifidobacterium has long been recognized to be a beneficial genus, constituting over 90% of total GI bacteria in breastfed infants.2 It has been shown to have multiple immunomodulating effects, such as increasing the production of secretory IgA and activity of both NK cells and neutrophils, as well as balancing Th1 and Th2 immune activity.3-5 It has also been shown to enhance mucosal barrier function in the colon, partly by upregulating tight junction molecules.6 In clinical trials, supplementation with BB536 has been shown to reduce allergic symptoms, decrease influenza infection, lower serum cholesterol levels, normalize elimination frequency, reduce pathogenic bacterial populations, and support normal GI tissue.7-11

Non-Medicinal Ingredients

Microcrystalline cellulose, calcium carbonate, vegetarian capsule (carbohydrate gum [cellulose], purified water, silica), vegetable grade magnesium stearate (lubricant).

Dosage

Recommended Adult Dose: 1–2 capsules, 2–3 times per day, or as directed by a health care practitioner. Take at least 2–3 hours before or after antibiotics.

Warnings

Discontinue use and consult a health care practitioner if symptoms worsen or persist beyond 3 days, or if you experience nausea, fever, vomiting, bloody diarrhea, or severe abdominal pain. Do not use if you have an immune-compromised condition (e.g., AIDS, lymphoma, or patients undergoing long-term corticosteroid treatment). This product may have come into contact with milk and gluten. Keep out of reach of children.

Allergens

Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use it if the seal is broken. For freshness, store in a cool, dry place.

Contraindications

Discontinue use and consult a health care practitioner if symptoms worsen or persist beyond 3 days, or if you experience nausea, fever, vomiting, bloody diarrhea or severe abdominal pain. Do not use if you have an immune-compromised condition (e.g., AIDS, lymphoma, or patients undergoing long-term corticosteroid treatment). This product may have come into contact with milk and gluten. Keep out of reach of children.

Drug Interactions

No known drug interactions exist. Separation by at least 2 hours from antibiotic use may improve the efficacy of Probiotic-Pro BB536.

References

1. Fumiaki Abe, Hirofumi Miyauchi, Ayako Uchijima, et al. Stability of bifidobacteria in powdered formula. International Journal of Food Science and Technology. 2009,44, 718–724.
2. Roger LC, Costabile A, Holland DT, et al. Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Microbiology. 2010 Nov;156(Pt 11):3329-41.
3. Iwabuchi N, Takahashi N, Xiao JZ, et al. In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria. Microbiol Immunol. 2007;51(7):649-60.
4. Xiao JZ, Kondo S, Yanagisawa N, et al. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin Exp Allergy. 2006 Nov;36(11):1425-35.
5. Akatsu H, Iwabuchi N, Xiao JZ, et al. Clinical Effects of Probiotic Bifidobacterium longum BB536 on Immune Function and Intestinal Microbiota in Elderly Patients Receiving Enteral Tube Feeding. JPEN J Parenter Enteral Nutr. 2012 Nov 27. [Epub ahead of print]
6. Takeda Y, Nakase H, Namba K, et al. Upregulation of T-bet and tight junction molecules by Bifidobacterium longum improves colonic inflammation of ulcerative colitis. Inflamm Bowel Dis. 2009 Nov;15(11):1617-8.
7. Xiao JZ, Kondo S, Yanagisawa N, et al. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol Int. 2007 Mar;56(1):67-75.
8. Namba K, Hatano M, Yaeshima T, et al. Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly. Biosci Biotechnol Biochem. 2010;74(5):939-45.
9. Kondo J, Xiao JZ, Shirahata A, et al. Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding. World J Gastroenterol. 2013 Apr 14;19(14):2162-70.
10. Odamaki T, Sugahara H, Yonezawa S, et al. Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. Anaerobe. 2012 Feb;18(1):14-8.
11. Andrade S, Borges N. Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol. J Dairy Res. 2009 Nov;76(4):469-74.
12. Clark PA, Martin JH. Selection of bifidobacteria for use as dietary adjuvants in cultured dairy foods: III. Tolerance to stimulated bile concentrations of human small intestines. Cult Dairy Prod J. 1994;29:18–21.