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Methylation Issues

Methylation Issues

What is methylation? Methylation is the process of taking a methyl group, one carbon and three hydrogens, into your body to support some major body functions, such as DNA methylation, thinking, fighting off toxins, and turning genes on and off. Simply put, it is one of the "chemicals" in the body that needs to be methylated to avoid serious health issues, like diabetes, cancer, and autism. Keep reading to know more about what is methylation and its importance in your body.

What Is Methylation? | Issues Explained!

In this Article:

Methylenetetrahydrofolate Reductase!

Methylation issues are present in virtually all children along the autism spectrum. Methylation problems result in low glutathione. Glutathione is the body's master antioxidant and plays a big role in detoxification. The most commonly known methylation issue is methylenetetrahydrofolate reductase (MTHFR), a family of enzymes in the methylation pathway.

MTHFR 677 and 1298!

The most researched methylation enzymes are MTHFR 677 and 1298. The numbers refer to where the anomaly occurs on the gene. The 677 is the most researched of these anomalies. The anomalies are either heterozygous (dissimilar) or homozygous (similar). These anomalies come from our parents. A heterozygous anomaly means one of the pairs of genes is involved. In other words, there's one normal gene from one parent and one anomaly from the other parent. These anomalies are pronounced snips (SNPs). If it affects both genes, then it's homozygous.

Heterozygous and Homozygous!

If the anomaly is heterozygous, then the efficiency of the enzyme decreases by around 30 percent. And, if homozygous, then the efficiency can drop to 20 to 30 percent from the normal rate. There are usually multiple SNPs affecting methylation, and it's the combination of these SNPs that causes a major glutathione deficiency.

Know more about what is methylation and its accompanying issues in this video below:


Having a good knowledge of what is methylation and its accompanying problems is an advantage. You get to understand what this process is about and how it can significantly affect your body if not in good condition. Most importantly, you know what to do and expect in case you or a loved one has poor methylation.

Want to share your opinion about what is methylation and its accompanying problems? We would like to hear from you in the comments section below!

Up Next: What Is Hyaluronic Acid | A Closer Look

Editor’s Note – This post was originally published on May 29, 2017, and has been updated for quality and relevancy.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. None of the nutritional products mentioned is intended to Diagnose, Treat, Cure or Prevent any Disease.