XYMOGEN, Adrenal Manager™ 120 Capsules

Adrenal Manager™ pairs glandulars with targeted nutrients to support the body’s response to everyday stressors. Among the comprehensive blend of nutrients are high-potency pantothenic acid and vitamin C, activated B vitamins, and mineral amino acid chelates. Gland and organ tissues are derived from an Argentinian bovine source that ensures safety and purity. *

• Supports the Body’s Response to Stress†
• Supports Energy Production and Metabolic Function†

Stress is caused by physiological, psychological, or emotional triggers (stressors) that cause a disturbance in the homeostasis of an organism. How we respond to those stressors (physiologically and psychologically) influences how well we cope with change and with ongoing stress. Structural or physical trauma, distress, poor diet, infection, toxic exposure, leaky gut, births, deaths, lack of sleep, temperature changes, electromagnetic radiation, and allergies or food sensitivities are all potential stressors. Combined, they amount to a total stress level and can ultimately disrupt homeostasis with direct effects on the autonomic nervous system, the hypothalamic-pituitary-adrenal (HPA) axis, and the cardiovascular, metabolic, and immune systems.[1] Specifically, research reveals that prolonged stress has a profound effect on the adrenal glands, lymph nodes, thymus gland, and gastrointestinal system.[2] Endocrinologist Hans Selye identified the various stages of the stress response (alarm, resistance, and exhaustion) and described the entire phenomenon as the general adaptation syndrome (GAS).

Micronutrients, such as vitamins, minerals, and antioxidants, are involved in most metabolic functions in the body. B vitamins are essential to energy generation within the cellular mitochondria, and a deficiency of any B vitamin can compromise mitochondrial function.[3,4] Riboflavin supports the respiratory chain, niacin supplies protons for oxidative phosphorylation, and pantothenic acid is required for coenzyme A production, metabolic enzyme complex formation, and fatty acid oxidation. Stressors can increase metabolic demand, energy expenditure, and micronutrient needs.[5] Micronutrient sufficiency and balance have been established as crucial to helping maintain a healthy psychological and physiological response to stress.[6] Unfortunately, experts estimate that a significant proportion of the general population does not consume adequate dietary levels of several micronutrients. Experts suggest that exogenous supplementation can improve micronutrient status and sufficiency and help support a healthy response to stress.†[7]

Clinical research supports the premise that micronutrient supplementation can favorably support the stress response in a variety of circumstances.[7] In a randomized, double-blind, placebo-controlled (RDBPC) trial, high-potency doses of B vitamins and vitamin C along with an array of minerals were studied for their effects on perceived stress scores (measuring one’s self-perception of stress) in 215 males aged 30 to 55 years. Results revealed significant improvements on the perceived stress scale (PSS), the profile of mood states (POMS), and the general health questionnaire (GHQ-12) for those taking the multivitamin/mineral supplement.[8] Another RDBPC study of 80 males revealed consistent and statistically significant modulation in anxiety and perceived stress in the men who took a high-potency multivitamin/mineral supplement compared to those who took the placebo. Participants taking the supplement also reported feeling less tired and better able to concentrate compared to their placebo-taking counterparts.[9] Similar results were achieved in a double-blind, placebo-controlled, double-center study of 300 subjects taking a multivitamin/mineral supplement, with significant improvement in baseline stress scores.[6] The levels of vitamin C, riboflavin, B6, pantothenic acid, and zinc provided in the recommended dose of two Adrenal Manager capsules twice daily meets or exceed the levels used in these clinical studies. The recommended daily dose of four capsules also provides 30 mg of niacin (compared to 50 mg used in studies) and 90 mg of magnesium (compared to 100 mg used in studies).†

Adrenal Manager also contains a blend of complementary nutrients and purified glandulars. Rhodiola Rosea, chlorella, grape seed extract, magnesium, zinc, chromium, bioflavonoids, and L-tyrosine are present at levels that allow for additional supplementation to round out their profile. Activated B vitamins and Albion® TRAACS® (the real amino acid chelate system) mineral amino acid chelates, along with other chelated minerals, are key features of the formula. Adrenal, parotid, thymus, and spleen glandulars are extracted from an Argentinian bovine source that ensures safety and purity.†

Other Ingredients:

Capsule (hypromellose and water), microcrystalline cellulose, vegetable stearic acid, magnesium stearate, medium-chain triglyceride oil, and silica.

Directions:

Take two capsules daily, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professionals. Do not use it if the tamper seal is damaged.

Storage:

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, eggs, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

References:

1. Brame AL, Singer M. Stressing the obvious? An allostatic look at critical illness. Crit Care Med. 2010 Oct;38(10 Suppl): S600-7. [PMID: 21164403]

2. Szabo S, Tache Y, Somogyi A. The legacy of Hans Selye and the origins of stress research: a retrospective 75 years after his landmark brief “letter” to the editor of Nature. Stress. 2012 Sep;15(5):472-8. [PMID: 22845714]

3. Depeint F, Bruce WR, Shangari N, et al. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. [PMID: 16765926]

4. Angelo G. What is metabolism? Linus Pauling Institute. http://lpi.oregonstate. edu/ss13/metabolism.html. Accessed October 19, 2013.

5. Askew EW. Environmental and physical stress and nutrient requirements. Am J Clin Nutr. 1995 Mar;61(3 Suppl):631S-637S. Review. [PMID: 7879730]

6. Schlebusch L, Bosch BA, Polglase G, et al. A double-blind, placebo-controlled, double-center study of the effects of an oral multivitamin-mineral combination on stress. S Afr Med J. 2000 Dec;90(12):1216-23. [PMID: 11234653]

7. Drake V. Micronutrients and Cognitive Function. Linus Pauling Institute. http:// lpi.oregonstate.edu/infocenter/cognition.html. Accessed October 12, 2013

8. Kennedy DO, Veasey R, Watson A, et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl). 2010 Jul;211(1):55-68. [PMID: 20454891]

9. Carroll D, Ring C, Suter M, et al. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl). 2000 Jun;150(2):220-5. [PMID: 10907676]