XYMOGEN, Appe-Curb™ 240 Capsules

XYMOGEN®

Free Shipping with purchase of $99 or more!

Cravings

Appe-Curb™ contains key amino acids to support the biosynthesis of neurotransmitters involved in appetite control, carbohydrate or fat cravings and mood. Chromium is present to support healthy glucose metabolism and support food intake regulation.* 5-Hydroxytryptophan (“5-HTP”) is a naturally-occurring amino acid precursor to serotonin. Numerous studies during the ‘90s, including those...
Title :
-
+

12 In Stock

Appe-Curb contains key amino acids to support the biosynthesis of neurotransmitters involved in appetite control, carbohydrate or fat cravings and mood. Chromium is present to support healthy glucose metabolism and support food intake regulation.*

5-Hydroxytryptophan (“5-HTP”) is a naturally-occurring amino acid precursor to serotonin. Numerous studies during the ‘90s, including those randomized, double-blind, and placebo-controlled, confirmed the safety and efficacy of 5-HTP in reducing appetite and food intake in obese healthy and non-insulin-dependent diabetic individuals.[1,2,3] A 2006 study in mice concluded, “5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.”[4] Vitamins B6 and C are important cofactors in the 5-HTP to serotonin pathway. Among the several serotonin receptors thus identified, the 5HT2C receptors are suspected to control food intake. Mice without this receptor exhibit increased food intake and become obese.*[5]

DL-Phenylalanine (DLPA) is a combination of the d- and the l- forms of this essential amino acid. Phenylalanine suppresses appetite by regulating the release of cholecystokinin, which in turn signals satiety in the brain. D-phenylalanine increases endorphins, while L-phenylalanine is an amphetamine-like stimulatory compound. DLPA has been found to elevate mood, curb appetite and reduce pain.*

L-Tyrosine, an essential amino acid is needed for conversion into the catecholamine neurotransmitters stress depletes dopamine, norepinephrine, and epinephrine. It is also a precursor for thyroxine. Doctors use tyrosine as a mood elevator, to increase alertness after sleep deprivation, and as an appetite suppressant; although support for the latter appears anecdotal.*[6]

L-Glutamine, well–recognized for gut and immune support, has also been espoused to reduce carbohydrate cravings and support alcohol withdrawal, although the mechanism of action for these benefits is not known.*[7,8]

Chromium, as chromium picolinate is widely used to optimize insulin function; thereby preventing swings in blood glucose levels that may be responsible for carbohydrate cravings. The mineral in the form present was indeed demonstrated to reduce carbohydrate cravings in a double-blind, placebo-controlled study.*[9,10]

  • Nutritional Support for Carbohydrate, Alcohol & Drug Cravings*
  • Supports Healthy Weight (by reducing carbohydrate cravings)*
  • Improve Sense of Wellbeing and Energy*
  • Supports Healthy Serotonin Levels*

 

Other Ingredients:

Capsule (hypromellose and water), stearic acid, magnesium stearate, medium-chain triglyceride oil, and silica.

Directions:

Take four capsules before breakfast and four capsules before lunch, or as directed by your healthcare professional. Consult your healthcare professional prior to use if you have, or suspect you have, a medical condition or are taking prescription drugs for depression, migraines, Parkinson’s disease, or psychiatric disorders. Not for use by children. Do not use it if the tamper seal is damaged.

Cautions:

Do not take if you are, or suspect you are, pregnant or if you are lactating. STORAGE: Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

References:

  1. Cangiano C, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992 Nov;56(5):863-7
  2. Cangiano C Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord 1998 Jul;22(7):648-544
  3. Amamoto T, Sarai K. On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression. Hiroshima J Med Sci. 1976 Sep;25(2-3):135-40 [PMID: 1088369]
  4. Yamada J, Sugimoto Y, Ujikawa M. Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan (5-HTP) in mice. Biol Pharm Bull. 2006 Mar;29(3):557-9 [PMID: 16508167]
  5. Rogers PJ, Blundell JE. Reanalysis of the effects of phenylalanine, alanine, and aspartame on food intake in human subjects. Physiol Behav. 1994 Aug;56(2):247-50 [PMID: 7938234]
  6. http://web.indstate.edu/thcme/mwking/aminoacidderivatives.html {accessed 09 July 07}
  7. Goodwin, F. APA Psychiatric News, Dec 5, 1986, in Atkins, R. Dr. Atkins VitaNutient Solution. Simon & Schuster, NY 1998 p169
  8. Rogers, L., Pelton, R. Quarterly Journal of Studies of Alcohol, 1957;18(4):581-87 in Atkins, R. Dr. Atkins Vita-Nutient Solution. Simon & Schuster, NY 1998 p169
  9. Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review. Diabetes Technol Ther. 2006 Dec;8(6):677-87 [PMID: 17109600]
  10. Docherty JP, et al. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract. 2005 Sep;11(5):302-14 [PMID: 16184071].

 

Agape Nutrition is proud to offer:

United States Postal Service (USPS) and United Parcel Service (UPS) as our standard shipping carriers and their services. Shipping rates are determined in real time or carrier book rate by weight and distance. Shipping Options are determined and reflected upon check out, for your choosing. If an option is not listed upon check out, your package may not meet the weight requirement or the service may not be available to the address location. Automated invoices for orders and shipping updates will drop into the email listed on the Agape Nutrition account. If SMS is accepted, automated updates will go to your phone via text message, you may also receive an email.

 

We pride ourselves on providing fast service at competitive prices.

  • Orders received by 12:00 pm Pacific Standard Time (PST) are generally processed the same day, and may ship within 24 hours. However, this is not a guarantee.
  • Orders received after 12:00 PM (PST) may process within 24 to 48 hours of receipt.
  • Tracking is updated within 24 to 48 hours of receipt and after processing and the package has shipped.

 

Processing and shipping times are:

  • Estimated and applicable during regular business hours.
  • Dependent upon the daily order volume at Agape Nutrition.
  • Dependent upon the daily order volume at the partner warehouse.
  • Dependent upon the time zones of our manufacture and distributor partners.
  • Dependent upon the shipping service practices and processing standards.

 

 

USPS Holiday Schedule             Agape Nutrition Holiday Schedule                 UPS Holiday Schedule

USPS  (Business Days) UPS (Business Days)
USPS Priority Mail (1-3 Business Day) UPS 2nd Day Air (2 Business Day)
 USPS Parcel Select (1-7 Business Day ) UPS 3 Day Select (1-3 Business Day)
USPS First Class Package (1-3 Business Day) UPS Ground (1-7 Business Day)

 Please Note: No Saturday Delivery Available.

 

Signature may be required for:

  • Orders of a high dollar amount.
  • Biotics Research shipments.
  • Vielight shipments.
  • Richway shipments.
  • All electronic devices.
  • All laboratory test kits.

 

 We have fixed shipping rates for a select few brand partners as per their shipping rate requirements, which may be different then our own and other distributor warehouses. Brands that apply: Vielight, Richway International, Biotics Research.

Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and / or natural disasters.

Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Due to no carrier guarantees, delayed or late packages are not eligible for refunds. This is a stipulation directly from the shipping carriers and is out of our control.

Shipping Service Guarantees Remain Suspended for Most Shipments. Please reach out to the shipping carrier for more information.

 

SHIPPING DISCOUNTS

 

Please see our FAQ page for additional questions and answers.

All discounts and promotional offers are calculated before shipping and handling rates are applied.


ORDER CANCELLATIONS

Orders cannot be cancelled or changed once the order has been placed and the confirmation is received.

Products may ship faster then expected, and many are automated to process directly after order confirmation. We work directly with top professional manufactures and distributors from across the United States, in all time zones. There are a lot of cogs and wheels turning to process and ship your order efficiently to meet an on time delivery target. When you request a cancellation or change of an order, it may take up to 72 hours to process your request. This process may involve voiding orders in computer systems, removing items from back order logs, pulling items from production schedules and sometimes stopping orders at the shipping dock or warehouse. Our order fulfillment may be performed by many quick hands, in different states and time zones. Therefore, we cannot offer or guarantee order cancellations after the order has been received.

  • Products may process and ship faster then expected.
  • Products may be automated to process directly after the order is confirmed.
  • Product warehouses may be in different states and time zones.
  • Orders may take up to 72 hours to process a cancellation or change. 

 

 DOMESTIC SHIPMENTS

Agape Nutrition is proud to ship to 52 states and territories of the United States.

  • All 50 United States (includes Washington DC, Hawaii, Alaska)
  • Armed Forces: Americas (AA)

Orders shipped to U.S. military addresses (APO/FPO/DPO) will ship via United States Postal Service (USPS) at the carrier book rate; normal delivery of these orders may be delayed by one (1) business day.

 

INTERNATIONAL SHIPMENTS
Agape Nutrition does not offer international shipping at this time, outside the 52 states, including Washington DC and Armed Forces Americas of the United States.

 

HEAT SENSITIVE SHIPMENTS
Products requiring shipment in a cool environment (perishable and frozen items) are subject to special shipping procedures due to their sensitive nature to ensure customers receive products in good condition. Heat sensitive items are shipped using sealed thermal bubble bag, ice pack or brick, resealable bag and extra padding to ensure a cool environment. We do not recommend heat sensitive item ship to territories of the United States, and we cannot be held responsible for cooled environment degradation to these destinations.

Agape Nutrition recommends that heat sensitive products ship with your preference of any 1-3 Day delivery service. We do not offer overnight or next day delivery service at this time. Saturday delivery is not available or guaranteed, unless offered by the shipping carrier as part of the normal delivery.

Please Note:

  • Heat sensitive items are not eligible for return, credit, or refund. As we cannot guarantee cool storage or efficacy of the product, after the order has been delivered.
  • Delays in shipping service delivery, caused an issue? See our return policy for further information.

       

      PACKAGE DELAYS

      Please be aware of severe weather and hazardous conditions in your area or other states that may affect the timeliness of your package delivery. Agape Nutrition can not be responsible for severe weather and unforeseen incidents that may impact the processing times and/or shipping services. We will work to ensure the safety of our employees while minimizing effects on service. Contingency plans are in place to help ensure that shipments arrive at their final destinations as quickly as conditions permit.

       

      Please Be Aware of Any Possible Shipping Delays:

      (1) Slight delays with fulfillment processing may occur as manufacture and distributor warehouses are experiencing higher than normal volume and demand for nutritional items.

      (2) Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and/or natural disasters. Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Please reach out to the shipping carrier for more information.

      (3) Please be aware of severe weather conditions in or around your location and surrounding states that my affect the timeliness of delivery.

      Recently Viewed