XYMOGEN, ATP Ignite™ Workout Mixed Berry 30 Servings

ATP Ignite^™ Workout is designed to meet the demanding needs of the body during and after exercise. This great-tasting drink mix provides a low-carb, zero-sugar combination of bioactive B vitamins, electrolytes, Albion TRAACS^® chelated trace minerals, key amino acids, herbs, and powerful antioxidants without the use of synthetic sweeteners or artificial ingredients. To fuel muscular excitability and take performance and recovery to the next level, ATP Ignite Workout features a unique blend of natural exercise enhancers that are patented and clinically tested. These include caffeine/pterostilbene co-crystal, Creapure^® creatine, and Peak ATP^® adenosine triphosphate. Let ATP Ignite Workout help you maximize your exercise time and energy output.*

• Enhances Exercise Performance*
• Helps Reduce Muscle Fatigue and Supports Muscle Power, Strength, and Growth with Peak ATP*
• Supports Recovery*
• Supports ATP Biosynthesis and Muscular Excitability*
• Provides an Alternative to Ordinary Caffeine*
• Supports Electrolyte Replacement*
• Provides Antioxidant Support with S-Acetyl-L-Glutathione and VitaminC*

All-Natural, No Sugars:

ATP Ignite Workout relies on natural ingredients, not ephedra or artificial stimulants, to help maximize exercise performance. Furthermore, it provides only five grams of carbohydrates and zero sugars. By using natural flavors and stevia in place of sugar and other carbohydrates, the typical “sugar high” that is associated with many energy drinks can be avoided. Equally important, ATP Ignite Workout contains no artificial colors.*

Peak ATP®

Oral supplementation of ATP (adenosine triphosphate) combined with resistance training has demonstrated ergogenic benefits.[1] Peak ATP is a patented form of ATP disodium that has been shown in human studies to enhance muscular growth, power, and strength while improving recovery. Proposed mechanisms of action include increased muscular excitability, improved blood flow, and increased anabolic signaling.[1-4] As a result of these effects, Peak ATP helps athletes push themselves to greater performance levels.*

Peak ATP supplementation (400 mg/d) has been shown to increase post-exercise ATP levels and athletic performance following repeated sprint bouts. Peak ATP also significantly increased vasodilation and blood flow after acute arm exercise bouts.[5,6] In a double-blind, placebo-controlled, crossover study, 400 mg of Peak ATP for 15 days “tended to reduce muscle fatigue while improving muscle low-peak torque through sets of exhaustive exercise.”[1] A double-blind placebo-controlled study showed that resistance-trained participants taking Peak ATP for 12 weeks experienced several benefits over placebo, such as increased strength (147%), increased power (30%), increased lean body mass (100%), and increased muscle thickness (96%). Additionally, body fat decreased in the supplemented group.[3] Data also suggests that Peak ATP helped prevent performance declines seen in overreaching.[3] Adding to these findings, in a randomized, double-blind, placebo-controlled study (n=42), Purpura et al found that 400 mg of Peak ATP for two weeks prevented exercise-induced declines in ATP and its metabolites and enhanced peak power and muscle excitability.*[7]

Creatine Monohydrate:

Creatine supplementation increases the amount of creatine in muscle tissue, heightens energy production, decreases muscle fatigue, and reduces lactic acid output. Significant improvements in body mass, fat-free body mass, oxygen uptake, sprint performance, weightlifting volumes, and overall exercise performance following creatine supplementation have been demonstrated.[8-10] In ATP Ignite Workout, a compounding effect of several ingredients is expected. In fact, the combinatory effects of caffeine, creatine, and amino acids have produced improvements in time to exhaustion (TTE) and peak velocity (PV) in humans.*[11]

Caffeine Pterostilbene Co-Crystal:

Caffeine pterostilbene co-crystal is an innovative ingredient that combines caffeine with pterostilbene—a highly bioavailable analog of resveratrol—to form a unique co-crystal structure. It appears that this unique structure affects the way the body utilizes caffeine. As such, it may offer significant advantages over caffeine alone. In a rat study (n=6), the half-life of caffeine from caffeine pterostilbene co-crystal was eight hours, while that of ordinary caffeine was just three hours.[12] In a preliminary, four-week, single-blind, crossover human study (n=12) that compared 232 mg of caffeine pterostilbene co-crystal (providing 99.76 mg of caffeine) to 100 mg of ordinary caffeine, the absorption of caffeine from caffeine pterostilbene co-crystal was approximately 30% slower and caffeine pterostilbene co-crystal delivered 30% more caffeine to the bloodstream. Furthermore, at six hours, 51% more caffeine from caffeine pterostilbene co-crystal was detected in serum compared to ordinary caffeine.*[13,14]

These data suggest that the effects of caffeine from caffeine pterostilbene co-crystal may last longer than the effects from ordinary caffeine and point to a potential for reducing total caffeine intake. Additionally, the extended half-life and slower absorption rate of caffeine from caffeine pterostilbene co-crystal may produce a more moderated and gradual finish, thereby preventing the “crash” associated with regular caffeinated energy products. While the results of these studies are promising, larger studies are needed to validate the findings and determine if these findings translate into a lengthened energy effect. Of interest, chlorogenic acids from coffee have been found to positively affect human fecal microbiota, including Bifidobacterium species, which could benefit host health.*[15]

Herbs and Amino Acids:

ATP Ignite Workout combines caffeine pterostilbene co-crystal in a proprietary blend with various herbs and amino acids, including green tea extract, coffee fruit extract, taurine, and L-arginine alpha-ketoglutarate. This proprietary blend is designed to complement the activities of caffeine pterostilbene co-crystal. Furthermore, some of these individual ingredients taken in high doses have roles in mitochondrial biogenesis and are known to positively influence exercise performance.*[16-18]

Electrolytes and Antioxidants:

Electrolytes—including sodium, potassium, and magnesium—are important for energy production, nerve transmission, muscle contractions, pH balance, fluid balance, and more. Conditions that promote excessive sweating and increased metabolic activity can require the replacement of these important minerals and increase the need for antioxidants. ATP Ignite Workout provides 130 mg of sodium, 280 mg of potassium, and 150 mg of magnesium in each serving. To support protection from free radicals, ATP Ignite Workout provides 500 mg of vitamin C in the form of four mineral ascorbates, as well as natural vitamin E, selenium, green tea extract, and s-acetyl-Lglutathione (SAG). SAG is an orally stable glutathione that has been shown to cross the membrane of the mitochondria, which increases the organelle’s activity and helps minimize reactive oxygen species.*

B Vitamins:

The B vitamins provided in ATP Ignite Workout are in their activated forms to optimize bioavailability and utilization. As essential parts of coenzymes, these water-soluble nutrients are integral to the complex biochemical processes that convert food to glucose and ATP—the energy used by cells. Vitamin B12 also works closely with folate to help make red blood cells and facilitate the work of iron in the body. Iron helps carry oxygen to all cells, including muscle cells, for use in the generation of energy.*

Other Ingredients:

Maltodextrin, citric acid, malic acid, natural flavors (no MSG), natural grape powder, stevia leaf extract, and silica.

Directions:

Dissolve the contents of one scoop in 6-12 oz of water according to preferred sweetness. On non-workout days, consume the effervescent drink in the AM on an empty stomach. On workout days, consume the effervescent drink once daily 30 minutes prior to the workout, or use it as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication, especially blood thinners, should discuss potential interactions with their healthcare professionals. Caffeine should not be combined with synephrine or ephedrine. Use cautiously if you have a history of abnormal heart rhythm. Do not use it if the tamper seal is damaged.

Storage:

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, artificial colors, artificial sweeteners, and artificial preservatives.

References:

1. Rathmacher JA, Fuller JC Jr, Baier SM, et al. Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high-intensity exercise sets. J Int Soc Sports Nutr. 2012 Oct 9;9(1):48. [PMID: 23046855]
2. Jäger R, Roberts MD, Lowery RP, et al. Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. J Int Soc Sports Nutr. 2014 Jun 13;11:28. [PMID: 25006331]
3. Wilson JM, Joy JM, Lowery RP, et al. Effects of oral adenosine-5’-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutr Metab (Lond). 2013 Sep 22;10(1):57. [PMID: 24330670]
4. Kichenin K, Decollogne S, Angignard J, et al. Cardiovascular and pulmonary response to oral administration of ATP in rabbits. J Appl Physiol (1985). 2000 Jun;88(6):1962-8. [PMID: 10846006]
5. Rauch J, Lowery RP, Silva J, et al. The oral bioavailability of ATP following an intense sprinting protocol. In: National Strength and Conditioning Association 2014 Annual Meeting, Las Vegas, NV. J Strength Cond Res. 2014;28(suppl 2): S53-S54. http://journals.lww.com/ nsca-jscr/Fulltext/2014/12001/NSCA_2014_Annual_Meeting.1.aspx. Accessed September 29, 2015.
6. Lowery R, Roberts M, Booth F, et al. Oral ATP administration improves blood flow responses to exercise in animal and human training models. In: Proceedings of the Tenth International Society of Sports Nutrition (ISSN) Conference and Expo, Colorado Springs, CO. J Int Soc Sports Nutr. 2013;10(suppl 1):P16. http://www.jissn.com/content/10/S1/P16. Accessed September 29, 2015.
7. Purpura M, Rathmacher JA, Sharp MH, et al. Oral adenosine-5’-triphosphate (ATP) administration increases postexercise ATP levels, muscle excitability, and athletic performance following a repeated sprint bout. J Am Coll Nutr. 2017 Jan 12:1-7. [PMID: 28080323]
8. Smith RN, Agharkar AS, Gonzales EB. A review of creatine supplementation in age-related diseases: more than a supplement for athletes. F1000Res. 2014 Sep 15;3:222. [PMID: 25664170]
9. Aguiar AF, Januário RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013 Apr;113(4):987-96. [PMID: 23053133]
10. Bemben MG, Lamont HS. Creatine supplementation and exercise performance: recent findings. Sports Med. 2005;35(2):107-25. [PMID: 15707376]
11. Fukuda DH, Smith AE, Kendall KL, et al. The possible combinatory effects of acute consumption of caffeine, creatine, and amino acids on the improvement of anaerobic running performance in humans. Nutr Res. 2010 Sep;30(9):607-14. [PMID: 20934602]
12. Single-dose comparative pharmacokinetic study of pterostilbene, caffeine, and combination of pterostilbene caffeine co-crystal in SD rats by oral route. Study report. Study No: VLL/0912/NG/D033; Version No.: 1.0. Genome Valley, Hyderabad, India: Vimta Labs Limited; November 2012:1-25. [on file]
13. A crossover, clinical evaluation to determine the relative bioavailability, pharmacokinetics, and safety of PURENERGY™ and pTeroPure® in healthy adult males. PK study summary. Miami, FL/Irvine, CA: Miami Research Associates/ChromaDex Inc.; 2013:1-34. [on file]
14. Purenergy™: A novel next-generation caffeine alternative. Irvine, CA: ChromaDex Inc.; September 10, 2014:1-5. [on file]
15. Mills CE, Tzounis X, Oruna-Concha MJ, et al. In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human fecal microbiota growth. Br J Nutr. 2015 Apr 28;113(8):1220-27. [PMID: 25809126]
16. Campbell B, Roberts M, Kerksick C, et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition. 2006 Sep;22(9):872-81. [PMID: 16928472]
17. Flôres MF, Martins A, Schimidt HL, et al. Effects of green tea and physical exercise on memory impairments associated with aging. Neurochem Int. 2014 Sep 6. [PMID: 25195719]
18. Pandareesh MD, Anand T. Ergogenic effect of dietary L-carnitine and fat supplementation against exercise induced physical fatigue in Wistar rats. J Physiol Biochem. 2013 Dec;69(4):799-809. [PMID: 23661316].