Bioclinic Naturals, Berberine HCL 500 mg 90 Veg Caps

Benefits

• Has 500 mg of berberine HCl per capsule, the amount used in clinical trials
• Helps support healthy glucose levels already within the normal range in a variety of ways, including the support of normal insulin sensitivity*
• Helps maintain healthy blood lipid levels, including triglycerides, total cholesterol, and LDL cholesterol already within the normal range* 
• Helps support Nrf-2, a key regulator of antioxidant activity that helps maintain nervous system health* 
• Helps maintain cardiovascular health in adults*
• Extracted from European barberry (Berberis vulgaris)
• Suitable for vegetarians/vegans

Feature Summary

Berberine may be helpful in cardiometabolic support through a variety of mechanisms.* It supports healthy insulin sensitivity and glucose levels already within the normal range by maintaining normal alpha-glucosidase activity and supporting healthy insulin receptors.*2,3 Additionally, it helps maintain healthy blood lipid levels already within the normal range.*1 Berberine also supports Nrf2, a key regulator of antioxidant activity that helps maintain nervous system health.*4

Berberine may help maintain a healthy body weight and waist circumference, help support healthy lipid levels (including cholesterol and triglycerides) within the normal range, and help maintain blood pressure within the normal range.*5,6 Berberine may also help support healthy HbA1c levels within the normal range.*7,8 Additionally, berberine may help organize the body’s response to cellular damage.*1

Dosage

1 capsule 2 times per day with meals or as directed by a health care professional.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.

Drug Interactions

Berberine may have an additive effect when combined with hypoglycemic medications such as metformin.* Berberine may also increase levels of cyclosporin A, and combined use should be avoided.*9 Berberine may inhibit cytochrome enzymes CYP2D6, 3A4, and CYP2C9, and the use of medications metabolized by these enzymes should be monitored.*10

References:

1. Dong, H., Zhao, Y., Zhao, L., et al. (2013). Planta Med, 79(6), 437-46.
2. Zhang, H., Wei, J., Xue, R., et al. (2010). Metabolism, 59(2), 285-92.
3. Li, Z.Q., Zuo, D.Y., Qie, X.D., et al. (2012). J Ethnopharmacol, 142(2), 474-80.
4. Hsu, Y.Y., Tseng, Y.T., Lo, Y.C. (2013). Toxicol Appl Pharmacol, 272(3), 787-96.
5. Yin, J., Xing, H., Ye, J. (2008). Metabolism, 57(5), 712-7.
6. Zhang, Y., Li, X., Zou, D., et al. (2008). J Clin Endocrinol Metab, 93(7), 2559-65.
7. Pérez-Rubio, K.G., González-Ortiz, M., Martinez-Abundis, E., et al. (2013). Metab Syndr Relat Disord, 11(5), 366-9.
8. Wei, W., Zhao, H., Wang, A., et al. (2012). Eur J Endocrinol, 166(1), 99-105.
9. Xin, H.W., Wu, W.C., Li, Q., et al. (2006). Methods Find Exp Clin Pharmacol, 28(1), 25-9.
10. Guo, Y., Chen, Y., Tan, Z.R., et al. (2012). Eur J Clin Pharmacol, 68(2), 213-7.