Bioclinic Naturals, BioFoundation-G 180 Tablets

Benefits

• Rate-limiting nutrients for glutathione production, necessary for detoxifying the body’s natural toxins*
• A full spectrum of vitamins and minerals, with 50 mcg (2000 IU) vitamin D3 per serving
• Clinically relevant amounts of resveratrol, lipoic acid, CoQ10, milk thistle, and green tea extract
• Antioxidant activity from bilberry and citrus extracts, lipoic acid, lycopene, and lutein*
• Highly bioactive and bioavailable nutrients, such as pyridoxal-5-phosphate and vitamin K2 (Menaquinone 7)

Feature Summary

BioFoundation-G is a comprehensive vitamin and mineral supplement to support healthy living in the modern world. This complete multivitamin and mineral formula contains clinically relevant amounts of nutrients such as N-acetyl-L-cysteine and R-alpha-lipoic acid, well established to increase cellular levels of glutathione, the most prevalent intracellular antioxidant.1,2,3 Glutathione is one of the most important conjugators of numerous endogenous toxins.*4,5,6

Glutathione support is linked to lower rates of cell death and apoptosis.7 BioFoundation-G provides physiologically relevant doses of milk thistle to help maintain liver health, CoQ10 to help support mitochondrial health, bilberry to provide antioxidant activity, and co-factors for critical detoxification enzymes.*8,9 It contains 50 mcg (2000 IU) of vitamin D3, 45 mcg of vitamin K2, and 275 mg of niacin per serving in its most bioavailable forms.10,11 It also provides the biological modifiers natural trans-resveratrol and green tea Phytosome, two nutrients shown to support healthy weight already within the normal range, healthy aging, cardiovascular health, metabolic health, and healthy stress response.*12,13,14,15

Non-Medicinal Ingredients

Microcrystalline cellulose, croscarmellose sodium, coating (carbohydrate gum [cellulose], glycerin), vegetable grade magnesium stearate (lubricant).

Dosage

Recommended Adult Dose: 3 tablets per day with meals, 2 hours before or after taking other medications, or as directed by a health care practitioner.

Warnings

Consult a health care practitioner prior to use if you have diabetes, kidney stones, a liver disorder, an iron deficiency, a history of non-melanoma skin cancer, peptic ulcer, excess stomach acid, if you are pregnant or breastfeeding, or if you are taking blood thinners, sulfonamides, or blood pressure medication. Consult a health care practitioner prior to use if you are taking prescription medications, as resveratrol may alter the effectiveness of these medications. Hypersensitivity (e.g., allergy) has been known to occur, in which case discontinue use. Do not use this product if you are taking antibiotics or nitroglycerin. If you experience sweating, paleness, chills, headache, dizziness, and/or confusion, discontinue use and consult a health care practitioner (as these may be symptoms of serious low blood sugar). Stop use and consult a health care practitioner if you develop symptoms of liver trouble such as yellowing of the skin/eyes (jaundice), stomach pain, dark urine, sweating, nausea, unusual tiredness, and/or loss of appetite. Rare, unpredictable cases of liver injury associated with products containing green tea extract have been reported (in Canada and internationally). People sensitive to nicotinic acid may experience flushing of the skin that is generally mild and transient. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, egg, fish, shellfish, tree nuts, or GMOs. Sealed for your protection. Do not use it if the seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner if you are taking blood thinners, or if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you have diabetes or kidney stones, or if you are taking sulfonamides or blood pressure medication. Consult a health care practitioner prior to use if you are taking prescription medication, as resveratrol may alter the effectiveness of these medications. Hypersensitivity (e.g., allergy) has been known to occur, in which case discontinue use. Do not use this product if you are taking antibiotics or nitroglycerin. Keep out of reach of children.

Drug Interactions

Vitamin K supplementation may decrease the efficacy of warfarin, or require more close monitoring of its administration.19 This product contains nutrients known to reduce hypertension and hyperglycemia and may require lower dosing or discontinuation of related medications.

References:

1. Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., et al. (2007). Current opinion in pharmacology, 7(4), 355–359.
2. Shay, K. P., Moreau, R. F., Smith, E. J., et al. (2009). Biochimica et biophysica acta, 1790(10), 1149–1160.
3. Becker, K., Pons-Kühnemann, J., Fechner, A., et al. (2005). Redox Report, 10(4), 215–226.
4. Awasthi, Y. C., Chaudhary, P., Vatsyayan, R., et al. (2009). Journal of toxicology and environmental health. Part B, Critical reviews, 12(7), 540–551.
5. Lee, D. H., & Jacobs, D. R., Jr (2009). Journal of epidemiology and community health, 63(11), 884–886.
6. Ljubisavljevic, S., Stojanovic, I., Cvetkovic, T., et al. (2014). Neuroimmunomodulation, 21(1), 13–20.
7. Circu, M. L., & Aw, T. Y. (2012). Biochimica et biophysica acta, 1823(10), 1767–1777.
8. Rosenfeldt, F., Marasco, S., Lyon, W., et al. (2005). The Journal of thoracic and cardiovascular surgery, 129(1), 25–32.
9. Kiruthiga, P. V., Shafreen, R. B., Pandian, S. K., et al. (2007). Basic & clinical pharmacology & toxicology, 100(6), 414–419.
10. Schurgers, L. J., Teunissen, K. J., Hamulyák, K., et al. (2007). Blood, 109(8), 3279–3283.
11. Logan, V. F., Gray, A. R., Peddie, M. C., et al. (2013). The British journal of nutrition, 109(6), 1082–1088.
12. Wightman, E. L., Haskell-Ramsay, C., Reay, J. L., et al. (2015). The British Journal of Nutrition, 114(9), 1427-1437.
13. Hoseini, A., Namazi, G., Farrokhian, A., et al. (2019). Food & function, 10(9), 6042–6051.
14. Brasnyó, P., Molnár, G. A., Mohás, M., et al. (2011). The British journal of nutrition, 106(3), 383–389.
15. Gilardini, L., Pasqualinotto, L., Di Pierro, F., et al. (2016). BMC complementary and alternative medicine, 16, 233.
16. Ford, S. K., Misita, C. P., Shilliday, B. B., et al. (2007). Journal of thrombosis and thrombolysis, 24(1), 23–27.