Bioclinic Naturals, CoQ10 - 400 mg 30 Softgels

Benefits

• Identical to the form produced by the human body for high bioavailability
• Helps support cardiovascular health, helps support mitochondrial health, and has antioxidant activity*
• A higher amount of 400 mg reduces the need to take multiple pills during the day and keeps pace with research
• Safe from contamination by undesirable residue or microorganisms, including bacteria or yeast
• In a base of natural rice bran oil and vitamin E to ensure a stabilized and highly absorbable form of CoQ10

Feature Summary

The majority of the clinical uses for CoQ10 are founded upon its role as an antioxidant, and its role in mitochondrial bioenergetics. It is a coenzyme for numerous reactions involved in cellular respiration and is required for the efficient formation of adenosine triphosphate (ATP), the cellular currency which drives the majority of enzymatic reactions.1,2 It inhibits peroxidation of cell membrane lipids as well as circulating lipoproteins.3,4 CoQ10 supports cardiac tissues by improving endothelial function and by having a direct anti-atherogenic effect, which results in lower blood pressure and improved ventricular contractility.5,6

High-dose CoQ10, ranging up to 2400 mg per day, has been used primarily for neurodegenerative diseases such as Parkinson’s and Huntington’s disease, though elevated doses have also been used in patients with severe cardiovascular disease or advanced breast cancer.7-10 Clinical trials have shown benefits for a wide range of cardiovascular conditions, including congestive heart failure, hypertension, and prevention of myocardial infarction.11-12 It also had clinical benefits for a number of other conditions, including migraine, periodontal disease, gingivitis, male infertility, and statin-induced myopathy.13-15

Supplement Facts:

Serving Size: 1 Softgel

Servings Per Container: 30

Amount Per Serving:

Coenzyme Q10 (Ubiquinone) 400 mg

Non-Medicinal Ingredients

Rice bran oil, softgel (gelatin, glycerin, purified water, carob), natural vitamin E.

Dosage

Recommended Adult Dose: 1 softgel per day, preferably with a meal, or as directed by a health care practitioner. Use for a minimum of 3 months to see beneficial effects.

Warnings

Consult a health care practitioner prior to use if you are pregnant or breastfeeding or if you are taking blood pressure medication or blood thinners. May cause nausea. Consult a health care practitioner if migraine frequency increases and associated nausea and vomiting persist or worsen. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use it if the seal is broken. For freshness, store in a cool, dry place.

Contraindications

No significant contraindications.

Drug Interactions

Although very little evidence supports this interaction, CoQ10 resembles vitamin K structurally, and a potential interaction is possible for those taking the anticoagulant Coumadin. Close monitoring of the INR is recommended with CoQ10 introduction in these patients. No other negative drug interactions are known for CoQ10, though a number of medications are thought to interfere with CoQ10 synthesis or function in the body, including statin or blood pressure medications, tricyclic antidepressants, and oral hypoglycemic agents.17

References:

1. Potgieter, M., Pretorius, E., Pepper, M.S., et al. (2013). Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev, 71(3), 180-8.
2. Littarru, G.P., Tiano, L. (2010). Clinical aspects of coenzyme Q10: an update. Nutrition, 26(3), 250-4.
3. Yubero-Serrano, E.M., Delgado-Casado, N., Delgado-Lista, J., et al. (2011). Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women. Age, 33(4), 579-90.
4. Littarru, G.P., Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol, 37(1), 31-7.
5. Gao, L., Mao, Q., Cao, J., et al. (2012). Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis, 221(2), 311-6.
6. Rosenfeldt, F.L., Haas, S.J., Krum, H., et al. (2007). Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens, 21(4), 297-306.
7. Chaturvedi, R.K., Beal, M.F. (2013). Mitochondria targeted therapeutic approaches in Parkinson’s and Huntington’s diseases. Mol Cell Neurosci, 55, 101-14.
8. Shults, C.W., Flint Beal, M., Song, D., et al. (2004). Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol, 188(2), 491-4.
9. Littarru, G.P., Tiano, L., Belardinelli, R., et al. (2011). Coenzyme Q (10), endothelial function and cardiovascular disease. Biofactors, 37(5), 366-73.
10. Yoritaka, A., Kawajiri, S., Yamamoto, Y., et al. (2015). Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease. Parkinsonism Relat Disord, 21(8) 911-6.
11. Molyneux, S.L., Florkowski, C.M., George, P.M., et al. (2008). Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol, 52(18), 1435-41.
12. Lei, L., & Liu, Y. (2017). Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials. BMC Cardiovasc Disord, 17(1), 196.
13. Littarru, G.P., Tiano, L. (2005). Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care, 8(6), 641-6.
14. Safarinejad, M.R., Safarinejad, S., Shafiei, N., et al. (2012). Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo-controlled, randomized study. J Urol, 188(2), 526-31.
15. Pringshelm, T., Davenport, W., Mackie, G., et al. (2012). Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci, 39(2 Suppl 2), S1-59.
16. Ernster, L., Dallner, G. (1995). Biochemical, physiological, and medical aspects of ubiquinone function. Biochim Biophys Acta, 1271(1), 195-204.
17. Bonakdar, R.A., Guarneri, E. (2005). Coenzyme Q10. Am Fam Physician, 72(6), 1065-70.