Bioclinic Naturals, CortAlign 90 Tablets

Benefits

• Helps to temporarily promote relaxation*
• Supports resistance to everyday stress and fatigue*
• Herbal formula, no glandular extracts
• Standardized herbal ingredients have 5% withanolides (ashwagandha), 1.5% honokiol (magnolia), and 0.1% berberine (Phellodendron)
• Suitable for vegetarians

Feature Summary

CortAlign has a variety of botanicals and nutrients to temporarily promote relaxation and support resistance to everyday stress and fatigue.* CortAlign may help maintain cortisol secretion within the normal range.* Ashwagandha helps promote relaxation and support resistance to occasional stress due to adaptogenic modulation of GABA receptors.*1,2  The KSM-66 formulation of ashwagandha specifically may help maintain serum cortisol levels within the normal range, facilitating relaxation, and a healthy stress response.*3

The combination of magnolia and Phellodendron (Relora® blend) supports resistance to everyday stress and fatigue.* Together, they help maintain salivary cortisol levels within the normal range, facilitate healthy stress perception, and support a healthy weight.*4,5  L-theanine (Suntheanine®) also helps promote relaxation, maintain cortisol levels within the normal range, and support a healthy stress response.*6,7 Phosphatidylserine plays a critical role in neuronal cell structure and function and helps facilitate a healthy stress response, support a healthy mood, and maintain cortisol levels within the normal range.*8,9

Non-Medicinal Ingredients

Microcrystalline cellulose, dibasic calcium phosphate dihydrate, hydroxypropyl cellulose, silica, croscarmellose sodium, stearic acid, coating (carbohydrate gum [cellulose], glycerin), vegetable grade magnesium stearate (lubricant).

Dosage

Recommended Adult Dose: 2 tablets per day or as directed by a health care practitioner.

Warnings

Consumption of alcohol, other drugs, or natural health products with sedative properties is not recommended. Consult a health care practitioner if you have benign prostate hypertrophy and/or prostate cancer, if you are taking any prescription medication, have a kidney disorder, or have blood pressure problems. Consult a health care practitioner prior to use if you suffer from any psychological disorder and/or condition such as frequent anxiety or depression. May cause heartburn, shaking hands, perilabial numbness, sexual dysfunction, and thyroid dysfunction. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Do not use it if you are pregnant or breastfeeding. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if the seal is broken. For freshness, store in a cool, dry place.

Contraindications

Do not use it if you are pregnant or breastfeeding.

Drug Interactions

L-theanine is known to have a hypotensive effect in some individuals, and concomitant use of CortAlign with anti-hypertensive drugs may potentiate their activity. Theoretically, the herbs present in CortAlign may have additive effects when used with sedative medications, such as benzodiazepines or CNS depressants, and should be used with caution when taken concomitantly.

References:

1. Candelario, M., Cuellar, E., Reyes-Ruiz, J.M., et al. (2015). Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors. J Ethnopharmacol, 171, 264-72.
2. Pratte, M.A., Nanavati, K.B., Young, V., et al. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med, 20(12), 901-8.
3. Chandrasekhar, K., Kapoor, J., Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med, 34(3), 255-62.
4. Talbott, S.M., Talbott, J.A., Pugh, M. (2013). Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr, 10(1), 37.
5. Garrison, R., Chambliss, W.G. (2006). Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med, 12(1), 50-4.
6. Ritsner, M.S., Miodownik, C., Ratner, Y., et al. (2011). L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry, 72(1), 34-42.
7. White, D.J., de Klerk, S., Woods, W., et al. (2016). Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients, 8(1).
8. Benton, D., Donohoe, R.T., Sillance, B., et al. (2001). The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci, 4(3), 169-78.
9. Hellhammer, J., Vogt, D., Franz, N., et al. (2014). A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal- axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health Dis, 13, 121.