Bioclinic Naturals, GABA-Pro Natural 90 Veg Capsules

Benefits

• Improves calmness and relaxation with daily stress, reduces the negative effects of caffeine consumption, and complements other antistress supplements
• Fast acting, effects can be felt in as little as five minutes and can last from four to six hours
• GABA-Pro uses Pharma GABA, the natural form of GABA which is superior to the synthetic. It is naturally manufactured via a fermentation process that utilizes Lactobacillus hilgardii, the bacterium used to ferment vegetables in the preparation of the traditional Korean dish kimchi.
• Gentle and non-addictive with virtually no side effects
• Suitable for vegetarians/vegans

Feature Summary

Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system, balancing the excitatory effects of glutamate on neuronal activity. The inhibitory effects of GABA are generally considered to lessen anxiety, relax muscle tension, and have sedative-like effects.1 In addition, conditions such as anxiety, depression, insomnia, and epilepsy have all been associated with low GABA concentration or activity.2,3 GABA has also been shown to cause a significant increase in alpha brain waves compared to control, indicative of a more relaxed state, as well as better concentration. In a clinical trial involving patients with a fear of heights, GABA-Pro was found to increase salivary levels of sIgA while crossing a suspension bridge, as compared to the control group whose salivary IgA levels dropped 35%.4 This is indicative of the stress-reducing effect of GABA-Pro. 5,6

Increasing GABA activity is also a therapeutic target for many medications used in the treatment of insomnia, often by targeting GABA receptors. This has the effect of decreasing waking, shortening sleep latency, and increasing slow-wave sleep.7,8

Non-Medicinal Ingredients

Rice powder, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant), silica.

Dosage

Recommended Adult Dose: 1–2 capsules 3 times per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks.

Warnings

 Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Do not use with alcohol. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/ vegans. Sealed for your protection. Do not use it if the seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Do not use with alcohol. Keep out of reach of children.

Drug Interactions

No known drug interactions have been documented; however, a theoretical concern exists for interaction with CNS depressants.

References:

1. Abdou, A.M., Higashiguchi, S., Horie, K., et al. (2006). Relaxation and immunity
   enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.
   Biofactors, 26, 201-208.
2. Gajcy, K., Lochyñski, S., & Librowski T. (2010). A role of GABA analogues in the treatment
   of neurological diseases. Current Medicinal Chemistry, 17(22), 2338-2347. 
3. Kendell, S.F., Krystal, J.H., & Sanacora, G. (2005). GABA and glutamate systems as
   therapeutic targets in depression and mood disorders. Expert Opinion on Therapeutic
   Targets, 9, 153-168.
4. Nemeroff, C.B. (2003). The role of GABA in the pathophysiology and treatment of anxiety
   disorders. Psychopharmacology Bulletin, 37(4), 133-146.
5. Yoto, A., Murao, S., Motoki, M., et al. (2012). Oral intake of aminobutyric acid affects mood and activities of the central nervous system during stressed conditions induced by mental tasks.
   Amino Acids, 43(3), 1331-1337.
6. Yang, Y., Koh, D., Ng, V., et al. (2002). Self-perceived work-related stress and the relation
   with salivary IgA and lysozyme among emergency department nurses. Occupational &
   Environmental Medicine, 59(12), 836-841.
7. Walsh, J.K., Salkeld, L., Knowles, L.J., et al. Treatment of elderly Primary Insomnia patients
   with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepiness.
   Sleep Medicine, 11(1), 23-30.
8. Lundahl, J., Staner, L., Staner, C., et al. (2007). Short-term treatment with gaboxadol
   improves sleep maintenance and enhances slow-wave sleep in adult patients with primary
   insomnia. Psychopharmacology (Berl), 195(1), 139-146.
9. Yamatsu, A., Yamashita, Y., Panharipande, P., et al. (2016). Effect of oral gamma-aminobutyric acid (GABA) administration on sleep and its absorption in humans.
   Food Science and Biotechnology, 25(2), 547-551. 
10. Fujibayashi, M., Kamiya, T., Takagaki, K., et al. (2008). Activation of autonomic nervous
    system activity by the oral ingestion of GABA. Journal of Japan Society of Nutrition and
    Food Sciences, 61, 129-133.