Bioclinic Naturals, PEA Palmitoylethanolamide 90 Vegcaps

Benefits

• For chronic pain relief
• Offers a natural source of PEA from non-GMO saffl ower oil
• Micronized for improved bioavailability
• Provides 400 mg PEA in each capsule, allowing for easy clinically relevant dosing
• Suitable for vegetarians and vegans

Feature Summary

Palmitoylethanolamide (PEA) is an endogenously produced lipid that mediates the resolution of neuroinflammation and clinically reduces pain from various sources. PEA is a type of fatty acid ethanolamine produced in microglia and mast cells, where it downregulates the activation of both cell types; levels of PEA are increased in brain areas involved in nociception and appear to modulate protective responses to both inflammation and pain. Its effects are mediated via direct activation of PPAR-a and GPR55 receptors, and potentially by indirect activation of CB1 and CB2 receptors and the TRPV1 channel (i.e., the capsaicin receptor).

In clinical trials, PEA has been shown to reduce pain levels from various chronic conditions (at least 6 months duration) where pain was not controlled by standard therapies, demonstrating effectiveness alone and when combined with standard treatments. PEA is efficacious for pain resulting from nerve compression syndromes, including sciatica and carpal tunnel syndrome. Randomized trials have also shown benefits for pain control for specific conditions, including TMJ, as well as for depressive symptoms in major depressive disorder when used in conjunction with antidepressants. In addition, PEA has been shown to improve endothelial function and reduce intraocular pressure among patients with ocular hypertension.

Non-Medicinal Ingredients

Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, and stearic acid.

Dosage

Recommended Adult Dose: 1 capsule 1–3 times per day or as directed by a health care practitioner.

Warnings

Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner before use if you are pregnant or breastfeeding. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. They are sealed for your protection. Only use it if the seal is fixed. For freshness, store in a cool, dry place.

Contraindications

No known contraindications exist, though safety during pregnancy and lactation has not been established.

Drug Interactions

Currently, there are no known drug interactions; PEA has been used in clinical trials as a stand-alone analgesic, as well as in conjunction with citalopram, pregabalin, gabapentin, amitriptyline, oxycodone, and duloxetine.