Bioclinic Naturals, Ubiquinol CoQ10 100 mg 60 Softgels

Benefits

• Increases plasma levels of CoQ10 significantly more per mg compared to ubiquinone
• Allows for higher peak plasma levels of CoQ10, especially when higher plasma CoQ10 is required
• Ubiquinol is a highly absorbable and bioavailable form of CoQ10
• Kaneka Q+ brand for ubiquinol is naturally produced via yeast fermentation and is free of the impurities of synthetically processed CoQ10
• Genetically modified organism (GMO) free, allergen free, and Kosher certified

Feature Summary

The only lipid-soluble endogenously synthesized antioxidant, CoQ10 (ubiquinone) has well-established roles as a free radical scavenger in both mitochondrial and lipid membranes, as an electron carrier essential to cellular respiration and ATP production, and it has recently been shown to influence gene expression.1-4

Given the central role of CoQ10 in mitochondrial function and cellular antioxidant protection, its clinical applications are extensive. Just a few of the many health conditions associated with requiring supplemental CoQ10 to boost levels are: general antioxidant support, cardiovascular disease (high blood pressure, congestive heart failure, cardiomyopathy, protection during cardiac surgery, high cholesterol being treated by drugs, especially statins), migraine headaches, male infertility, Alzheimer’s (prevention) and Parkinson’s disease (prevention and treatment), and macular degeneration.9-13 

The reduced form of CoQ10, ubiquinol, has emerged as a more effective therapy for increasing plasma levels of CoQ10 than most forms of ubiquinone, due to its increased solubility.14,15

Non-Medicinal Ingredients

Softgel (gelatin, glycerin, purified water, carob), yellow beeswax, non-GMO sunflower lecithin, vitamin E (non-GMO sunflower oil).

Dosage

Recommended Adult Dose: 1 softgel 1–3 times per day or as directed by a health care practitioner.

Warnings

Consult a health care practitioner before use if you are taking blood pressure medication or blood thinners, or if you are pregnant or breastfeeding. Keep out of reach of children.

Allergens

It contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. They are sealed for your protection. Do not use it if the seal is broken. For freshness, store in a cool, dry place.

Contraindications

Consult a health care practitioner before use if you are taking blood pressure medication or blood thinners, or if you are pregnant or breastfeeding. Keep out of reach of children.

Drug Interactions

Although existing evidence has not found an interaction, CoQ10 resembles vitamin K structurally, potentially interfering with the anticoagulant warfarin. Close monitoring of the INR is recommended with CoQ10 introduction in these patients. No other negative drug interactions are known for CoQ10, though some medications are thought to interfere with CoQ10 synthesis or function in the body, including statin medications, tricyclic antidepressants, and oral hypoglycemic agents.16

Reference

1. Potgieter, M., Pretorius, E., Pepper, M.S., et al. (2013). Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev, 71(3), 180-8.
2. Littarru, G.P., Tiano, L. (2010). Clinical aspects of coenzyme Q10: an update. Nutrition, 26(3), 250-4.
3. Littarru, G.P., Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol, 37(1), 31-7.
4. González-Guardia, L., Yubero-Serrano, E.M., Delgado-Lista. J., et al. (2014). Effects of the Mediterranean Diet Supplemented With Coenzyme Q10 on Metabolomic Profiles in Elderly Men and Women. J Gerontol A Biol Sci Med Sci, 70(1), 78-84.
5. Gao, L., Mao, Q., Cao, J., et al. (2012). Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis, 221(2), 311-6.
6. Rosenfeldt, F.L., Haas, S.J., Krum, H., et al. (2007). Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens, 21(4), 297-306.
7. Shults, C.W., Flint Beal, M., Song, D., et al. (2004). Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol, 188(2), 491-4.
8. Yoritaka, A., Kawajiri, S., Yamamoto, Y., et al. (2015). Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson’s disease. Parkinsonism Relat Disord, 21(8), 911-6.
9. Littarru, G.P., Tiano, L. (2005). Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care, 8(6), 641-6.
10. Littarru, G.P., Tiano, L., Belardinelli, R., et al. (2011). Coenzyme Q (10), endothelial function and cardiovascular disease. Biofactors, 37(5), 366-73.
11. Lei, L., Liu, Y. (2017). Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials. BMC Cardiovasc Disord, 17(1), 196.
12. Pringshelm, T., Davenport, W., Mackie, G., et al. (2012). Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci, 39(2 Suppl 2), S1-59.
13. Safarinejad, M.R., Safarinejad S, Shafiei, N., et al. (2012). Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo-controlled, randomized study. J Urol, 188(2), 526-31.
14. Failla, M.L., Chitchumroonchokchai, C., Aoki, F. (2014). Increased Bioavailability of Ubiquinol Compared to That of Ubiquinone Is Due to More Efficient Micellarization during Digestion and Greater GSH-Dependent Uptake and Basolateral Secretion by Caco-2 Cells. J Agric Food Chem, 62(29), 7174-82.
15. Langsjoen, P.H., Langsjoen, A.M. (2014). Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev, 3(1), 13-17.
16. Bonakdar, R.A., Guarneri, E. (2005). Coenzyme Q10. Am Fam Physician, 72(6), 1065-70.