Bioclinic Naturals, Vitamin K2, D3 and A 30 mL

Benefits

• Offers balance of key fat-soluble vitamins, A, D, and K, critical to bone health
• Contains vitamin K2 (MK-7), the most bioactive and long-lasting form
• K2 (MK-7) helps increase vertebral bone mineral density among postmenopausal women
• Provides vitamin D3 effective in maintaining blood levels of 25-OH vitamin D23
• Optimal form of vitamin A, palmitate
• Suitable for vegetarians

Feature Summary

Vitamin K2, D3 &A provides clinically relevant doses of the three fat-soluble vitamins essential to optimal bone health. Although needed for cardiovascular health, blood sugar regulation, immune function, and inflammation control, vitamins A, D, and K2 have complementary physiological bone-related functions, such as modulating gene expression in osteoblasts and carboxylating osteocalcin, an enzyme needed for bone formation.1 This is exemplified by a reduction in undercarboxylated osteocalcin and an increase in bone mineral density (BMD) in postmenopausal women when vitamin K is added to vitamin D supplementation.2

Vitamin D has diverse and significant functions in multiple body systems, and widespread deficiency magnifies these crucial roles.3,4 Supplementation is associated with a well-established reduction in osteoporotic fracture.5 Correcting a vitamin D deficiency is critical when supplementing with vitamin A, as vitamin A appears to promote bone health if vitamin D levels are adequate.6,7,8 Vitamin K is now recognized as being necessary not only for coagulation but also for the carboxylation of enzymes critical for both bone and blood vessel health.9-13 Indeed, meta-analysis has shown improvement in vertebral BMD and reduction in fracture among post-menopausal women with osteoporosis, while controlled trial data shows a reduction in the age-related decline in BMD among healthy postmenopausal women.14,15 The naturally derived MK-7 form in Vitamin K2, D3 &A has a longer half-life than any other form.16

Non-Medicinal Ingredients

Medium chain triglycerides, organic flaxseed oil, natural vitamin E (non-GMO sunflower oil), natural vanilla flavor.

Dosage

1 serving (0.25 ml) per day or as directed by a health care practitioner.

Warnings

Consult a health care practitioner before use if you are taking blood thinners. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use it if the seal is broken. For freshness, store in a cool, dry place.

Drug Interactions

Vitamin K may antagonize the effect of some anticoagulant medications, and concurrent use should be medically supervised. When taken with a thiazide medication (diuretic), vitamin D may increase the risk for hypercalcemia. Also, vitamin D may improve insulin sensitivity and lower blood pressure, requiring a reduction in the dosage of hypertension and/or diabetic medications. Vitamin A should not be taken with other synthetic retinoids, such as acitretin or bexarotene.

References

1. Doyon, M., Mathieu, P., & Moreau, P. (2013). Decreased expression of g-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein. Cardiovasc Res, 97(2), 331-8.
2. Cockayne, S., Adamson, J., Lanham-New, S., et al. (2006). Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med, 166(12), 1256-61.
3. Je, S.H., Joo, N.S., Choi, B.H., et al. (2011). Vitamin K supplement, vitamin D, and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty years old. J Korean Med Sci, 26(8), 1093‐8.
4. Van Ballegooijen, A.J., Pilz, S., Tomaschitz, A., et al. (2017). The synergistic interplay between vitamins D and K for bone and cardiovascular health: a narrative review. Int J Endocrinol, 7454376.
5. Dickens, A.P., Lang, I.A., Langa, K.M., et al. (2011). Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs, 25(8), 629-39.
6. Martins, D., Wolf, M., Pan, D., et al. (2007). Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med, 167(11), 1159-65.
7. Prentice, R.L., Pettinger, M.B., Jackson, R.D., et al. (2013). Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int, 24(2), 567-80.
8. Yao, P., Bennett, D., Mafham, M., et al. (2019). Vitamin D and Calcium for the prevention of fracture: a systematic review and meta-analysis. JAMA Netw Open, 2(12), e1917789.
9. Caire-Juvera, G., Ritenbaugh, C., Wactawski-Wende, J., et al. (2009). Vitamin A and retinol intakes and the risk of fractures among participants of the Women’s Health Initiative Observational Study. Am J Clin Nutr, 89(1), 323-30.
10. Bettoun, D.J., Burris, T.P., Houck, K.A., et al. (2003). Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol, 17(11), 2320-8.
11. Ribaya-Mercado, J.D., & Blumberg, J.B. (2007). Vitamin A: is it a risk factor for osteoporosis and bone fracture? Nutr Rev, 65(10), 425-38.
12. Balasuriya, C.N.D., Larose, T.L., Mosti, M.P., et al. (2019). Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up. PLoS One, 14(9), e0222712.
13. Gudmundsdottir, S.L., Hrafnkelsson, H., Sigurdsson, E.L., et al. (2020) Serum 25 hydroxyvitamin D concentrations in 16-year-old Icelandic adolescent and its association with bone mineral density. Public Health Nutr. 23(8), 1329‐33.
14. Geleijnse, J.M., Vermeer, C., Grobbee, D.E., et al. (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J. Nutr, 134(11), 3100-5.
15. McCann, J.C., & Ames, B.N. (2009). Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr, 90(4), 889-907.
16. Schurgers, L.J., Cranenburg, E.C.M., & Vermeer, C. (2008). Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost, 100(4), 593-603.
17. Yamaguchi, M., & Weitzmann, M.N. (2011). Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-kB activation. Int J Mol Med, 27(1), 3-14.
18. Yasui, T., Miyatani, Y., Tomita, J., et al. (2006). Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women. Gynecol Endocrinol, 22(8), 455-9.
19. Huang, Z.B., Wan, S.L., Lu, Y.J., et al. (2015). Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int, 26(3), 1175-86.
20. Knapen, M.H.J., Drummen, N.E., Smit, E., et al. (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int, 24(9), 2499-507.
21. Schurgers, L.J., Teunissen, K.J.F., Hamulyak, K., et al. (2007). Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood, 109(8), 3279-83.
22. Sato, T., Inaba, N., & Yamashita, T. (2020). MK-7 and Its effects on bone quality and strength. Nutrients, 12(4):965.
23. Logan, V.F., Gray, A.R., Peddie, M.C., et al. (2013). Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25 hydroxyvitamin D status over the winter months. Br J Nutr, 109(6), 1082-8.