XYMOGEN, Corticare B™ 120 Capsules

Corticare B^™ is formulated to support the body’s efforts in adrenal hormone production and energy generation. It provides activated B vitamins, vitamin C, and L-carnitine, as well as BioPerine^® to support nutrient absorption. The Quatrefolic^® form of 5-methyltetrahydrofolate (5-MTHF) is present for optimal folate bioavailability. L-carnitine enhances the activation of pantothenate kinase—the first, a most critical enzyme involved in the metabolic conversion of pantothenic acid to coenzyme A.*

• Supports Adrenal Hormone Synthesis*
• Supports Adrenal Physiological Functions*
• Supports Energy Production*

Pantothenic Acid (as d-calcium pantothenate) Pantothenic acid, a B complex vitamin also known as vitamin B5, occurs as an unstable oil. Its water-soluble salt, d-calcium pantothenate, is the form most commonly used in supplements. D-calcium pantothenate is composed of 91.5% pantothenic acid and 7.5% calcium. Among its many physiological functions, pantothenic acid is a precursor to the synthesis of coenzyme A (CoA), is an essential cofactor for ATP production, and is essential to the adrenal cortex for the production of glucocorticoids.*

Vitamin B6 (as pyridoxal 5’-phosphate and pyridoxine HCl) Corticare B™ provides vitamin B6 as both pyridoxine HCl and activated pyridoxal 5’-phosphate, the form in which B6 is transported in the blood. Physiologically, vitamin B6 influences the adrenal glucocorticoid receptor, stimulates the secretion of adrenal catecholamines, and aids in sodium and potassium balance.*

Vitamin C (as magnesium ascorbate) The release of adrenocorticotropic hormone (ACTH) from the pituitary gland in tandem with the body’s physiological response to stress will deplete the relatively large amount of vitamin C typically stored in the adrenal cortex.[1] This vitamin is essential for the synthesis of epinephrine, the hormone secreted by the adrenal medulla in response to stress. Epinephrine, in turn, plays a role in the synthesis of aldosterone, the hormone that regulates blood pressure, volume, and pH.*

Folate (as calcium folinate and 5-MTHF) Corticare B provides the activated form of folic acid—5-MTHF as Quatrefolic[2]—to ensure superior bioavailability. Folic acid is important for building and repairing protein that may be broken down by stress hormones. It is also key to the synthesis of serotonin, a neurotransmitter that affects mood, appetite, and sleep,[3, 4] all of which are often negatively affected by stress.*

L- Carnitine (as tartrate) This conditionally essential nutrient derived from lysine is needed for the “carnitine shuttle.” It transports long-chain fatty acyl CoA from the outside to the inside of the mitochondria, making it a key nutrient in the production of energy.*

BioPerine® This patented extract of black pepper (Piper nigra) has been shown to significantly enhance the availability of vitamin C and vitamin B6.*[5]

Other Ingredients:

Capsule (hypromellose and water), microcrystalline cellulose, stearic acid, magnesium stearate, and silica.

Directions:

Take one capsule twice daily, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professionals. Do not use it if the tamper seal is damaged.

Storage:

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

References:

1. Murray RK, Granner DK, Mayes PA, et al. Harper’s Biochemistry. 25 ed. Stamford, CT: Appleton & Lange; 2000.

2. Quatrefolic ® - The fourth generation folate. www.quatrefolic.com. Accessed July 12, 2011.

3. Miller AL. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev. 2008 Sep;13(3):216-26. [PMID: 18950248]

4. Trivedi MH. The link between depression and physical symptoms. Prim Care Companion J Clin Psychiatry. 2004;6(Suppl 1):12-6. [PMID: 16001092]

5. BioPerine® - An Ingredient of Sabinsa. www.bioperine.com. Updated April 20, 2010. Accessed July 12, 2011.