XYMOGEN, MenoFem™ 90 Capsules

MenoFem^™ is a unique formula integrating Native American, Chinese, and Ayurvedic herbs to provide balanced support to menopausal women.*

• Supports Healthy Hormone Balance During Perimenopause and Menopause*
• Helps Relieve Bothersome Symptoms of Normal Perimenopause and Menopause, Such as Hot Flashes.*

Eighty percent of American women experience common symptoms while going through the two-to-ten–year perimenopausal and menopausal transition. MenoFem™ addresses a broad spectrum of normal menopausal complaints, making it an attractive option in varied clinical settings.*

Black Cohosh (Cimicifuga racemosa) is an herb American Indians used for gynecological support, including relief from common, normal menstrual symptoms such as cramps and related low-back discomfort. Research shows that black cohosh effectively maintains a sense of calmness and healthy outlook, and it may help address menopause-associated vasomotor symptoms.[1,2] According to the medical literature, black cohosh is beneficial to vaginal superficial cells and bone health without having a potentially detrimental effect on the endometrium or follicle-stimulating hormone (FSH) levels. According to Ruhlen et al., black cohosh may exert its benefits through selective estrogen receptor modulation, serotonergic pathways, antioxidant activity, or inflammatory pathways.*[3]

Dong Quai (Angelica sinensis) has its origins in China, Japan, and Korea, where it is used to balance the female cycle. Dong Quai works best in combination with other herbs to support menstrual regularity. Dong Quai can nourish dry, thin vaginal tissues.*[4]

Licorice (Glycyrrhiza glabra) functions as a weak phytoestrogen and has been reputed to aid in sexual arousal. Research suggests that glabridin, an isoflavone in licorice, is an estrogen-receptor agonist and supports normal breast cell growth. Licorice has been shown to have potential for supporting healthy bone mineral density in postmenopausal women and for inhibiting serotonin re-uptake.[5] It is used for liver and adrenal support, the latter being important as ovarian estrogen synthesis declines.*

Chasteberry (Vitex agnus-castus) supports symptomatic relief of common perimenopausal and menopausal symptoms. It appears to significantly compete for binding at the estrogen receptors. Chasteberry has normalized short luteal phases and progesterone synthesis. The popular herb may help relieve the common, transient symptom of mild breast tenderness possibly by inhibiting prolactin secretion. Chasteberry can help support a normal, healthy attitude during the perimenopausal transition.*[6]

Wild Yam (Dioscorea villosa) has long been used to support female cycles and functions as a phytohormone. Red Clover (Trifolium pratense) is considered a phytoestrogen. Its contents include genistein and salicylic acid. While red clover is helpful in reducing flushing, it does not increase breast density or raise estradiol levels.[7] This herb has shown a positive effect on vaginal cytology and can help maintain a healthy cellular response to hormone-induced discomfort in urinary tract tissues. Scientific evidence suggests that red clover can also support healthy blood lipids and bone health.*[1,8]

Dandelion Root (Taraxacum officinale) has been commonly used for its ability to help maintain healthy fluid balance and for its cleansing effects. In vitro research suggests that the active constituents in dandelion—which include luteolin, quercetin, and inulin—suppress COX-2 and inducible nitric oxide synthase, increase antioxidant activity, upregulate phase II detoxification, and support bifidobacteria growth.*[9-11]

Motherwort (Leonurus cardiaca) is a phytoestrogen especially helpful for maintaining an even heartbeat, a normal body temperature, and a healthy menstrual cycle. It has long been used to support the body’s healthy response to pain, maintain healthy muscle function, and provide physical and emotional comfort and stability.*[12]

Ashwagandha (Withania somnifera) Within the system of Ayurveda, ashwagandha is classified as a rasayana (rejuvenation) and is expected to promote physical and mental health, help rejuvenate the body, and increase longevity.*[13,14]

Other Ingredients:

Capsule (hypromellose and water), microcrystalline cellulose, stearic acid, magnesium stearate, and silica.

Directions:

Take one capsule daily, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if the tamper seal is damaged.

Cautions:

Do not take it if you are pregnant or lactating.

Storage:

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

References:

1. Geller SE, Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what does not. J Womens Health(Larchmt). 2005 Sep;14(7):634-49. [PMID: 16181020]
2. Nappi RE, Malavasi B, Brundu B, et al. Efficacy of Cimicifuga racemosa on climacteric complaints: a randomized study versus low-dose transdermal estradiol. Gynecol Endocrinol. 2005 Jan;20(1):30-5. [PMID: 15969244]
3. Ruhlen RL, Sun GY, Sauter ER. Black cohosh: Insights into its mechanism(s) of action. Integr Med Insights. 2008;3:21-32. [PMID: 21614156]
4. Chen JK, Chen TT. Chinese Medical Herbology and Pharmacology. City of Industry, CA: Art of Medicine Press, Inc; 2001:645, 919.
5. Somjen D, Katzburg S, Vaya J, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):241-6. [PMID:15336701]
6. Chopin Lucks B. Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154]. Complement Ther Nurs Midwifery. 2003 Aug;9(3):157-60. [PMID: 12852933]
7. Atkinson C, Compston JE, Day NE, et al. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebocontrolled trial. Am J Clin Nutr. 2004 Feb;79(2):326-33 [PMID: 14749241].
8. van de Weijer PH, Barentsen R. Isoflavones from Red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas. 2002 Jul 25;42(3):187-93. [PMID: 12161042]
9. Schütz K, Carle R, Schieber A. Taraxacum—a review on its phytochemical and pharmacological profile. J Ethnopharmacol. 2006 Oct 11;107(3):313-23. [PMID: 16950583]
10. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol. 2001 Oct;53(10):1323-29. [PMID: 11697539]
11. Natural Medicines Comprehensive Database. Dandelion.[ Full Monograph] http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=&s=ND&pt =100&id=706&fs=ND&searchid=34505380. Accessed May 7, 2012.
12. American Botanical Council. Motherwort herb. http://cms.herbalgram.org/ expandedE/Motherwortherb.html. Accessed May 7, 2012.
13. Kulkarni SK, Dhir A. Withania somnifera: an Indian ginseng. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1093-105. [PMID: 17959291]
14. Dhuley JN. Effect of ashwagandha on lipid peroxidation in stress-induced animals. J Ethnopharmacol. 1998 Mar;60(2):173-8. [PMID: 9582008]