XYMOGEN, Mitochondrial Renewal Kit 60 Packets
The XYMOGEN Mitochondrial Renewal Kit (MRK) is formulated to support and promote mitochondrial biogenesis and function. MRK supplies three active, orally bioavailable formulations— N.O.max™ ER, Resveratin™ Plus, and ALAmax™ CR—which function synergistically to support the critical role that mitochondria play in metabolism. The functional components found in the MRK are safe, well-tolerated, and have been uniquely prepared to enhance both absorption and overall bioavailability to maximize patient benefit and satisfaction.*
- Promotes Efficient Use of Insulin and Glucose in the Body*
- Enhances Conversion of Glucose into Usable Energy*
- Promotes Healthy Aging*
- Increases Exercise Performance*
- Promotes Nitric Oxide (NO) Production*
- Supports Cardiovascular and Endothelial Function*
- Improves Antioxidant Status and Resistance to Oxidative Stress*
Mitochondria are the organelles inside cells that produce energy. Mitochondria represent approximately 10% of total body weight and play several roles in the body. Primarily, they are cellular “fuel stations” responsible for supplying greater than 95% of the body’s energy needs.[1] Mitochondrial biogenesis is the process by which new mitochondria are produced, and it is believed to delay the effects of aging and the onset of age-associated diseases.[2-5] This complex process involves more than 1,000 genes[2] and is responsible for producing 20% of total cellular protein.[1] Aerobic exercise and caloric restriction are the two most compelling approaches to stimulate mitochondrial biogenesis,[2,3] most notably by activating the “master regulator” of mitochondrial biogenesis and function known as PGC-1α, a transcriptional coactivator. Dysregulation of PGC-1α has been implicated in aging and the pathogenesis of numerous ageassociated complications, such as poor glucose control, increased fat mass with accompanying decrease in muscle mass, and various neurological conditions.*
PGC-1α–deficient animals display defects in energy metabolism, glucose disposal, and insulin action. These deficient animals also display reduced resistance to oxidative stress, increased fat mass, decreased muscle mass, impaired exercise performance, and other issues suggestive of an impaired ability to adapt to metabolic and physiological stress.[6] Conversely, PGC-1α activation contributes to an increase in metabolic fitness in the form of an increased metabolic rate, improved glucose disposal and insulin function, enhanced fatty acid oxidation, increased resistance to oxidative stress, decreased fat mass, and increased muscle mass and exercise performance.*
The nutrients in the Mitochondrial Renewal Kit have been selected for their oral bioavailability and also for their safety and efficacy in activating PGC-1α and upstream cellular signaling cascades. These actions mimic the protective effects of exercise and caloric restriction on mitochondrial biogenesis, metabolic fitness, and aging. The key signaling cascades affected include those involving nitric oxide (N.O.max™ ER), SIRT1 (Resveratin™ Plus), and AMPK (ALAmax™ CR). Ultimately, it is the stimulation of these cascades that leads to the activation of PGC-1α and subsequent upregulation of mitochondrial biogenesis and promotion of overall metabolic fitness. For optimal benefit, combine this product with a healthy diet and exercise regimen.*
N.O.max™ ER is an extended-release formulation containing L-Arginine α-ketoglutarate and ACTINOS™, a proprietary whey peptide fraction. This combination serves as an effective nitric oxide (NO) precursor. As a vasodilator, NO exerts a protective effect on blood vessel endothelium.[7] NO plays an important role in intracellular communication within the cell, acting as a trigger for mitochondrial biogenesis.*[8]
Resveratin™ Plus provides a distinctive bioflavonoid complex with resveratrol, quercetin, and pterostilbene (bio-optimized methylated resveratrol).[9] These three antioxidants work together and continue to interest researchers in cardiovascular health and aging.*
ALAmax™ CR is a multifunctional antioxidant that can neutralize free radicals in both the aqueous-based and lipid-based environments of cells. In addition, ALAmax CR’s controlled-release formulation provides extended protection[10] by promoting the synthesis of glutathione and “recharging” other important antioxidants, such as vitamin C, vitamin E, and coenzyme Q10.*
Other Ingredients for ALAmax CR:
Hydroxypropyl methylcellulose, microcrystalline cellulose, hydropropyl cellulose, dicalcium phosphate, magnesium stearate, silica, and coating (hydroxypropyl methylcellulose and medium-chain triglycerides).
Other Ingredients for N.O.max ER:
Hydroxypropyl methylcellulose, stearic acid, hydroxypropyl cellulose, silica, coating (hydroxypropyl methylcellulose and medium-chain triglycerides), and magnesium stearate.
Other Ingredients for Resveratin Plus:
Capsule (hypromellose and water), microcrystalline cellulose, stearic acid, magnesium stearate, silica, and medium-chain triglyceride oil.
N.O.max ER Contains: Milk
Directions:
Consume the contents of one packet with 8 oz. water, 30 minutes before breakfast and 30 minutes before lunch, or as directed by your healthcare professional. Individuals with a medical condition (including diabetes or cold sores), who are taking prescription drugs, who are pregnant or lactating, or who are under the age of 18 should consult their healthcare professional before use. Do not use it if the packet is damaged.
Storage:
Keep closed in a cool, dry place out of reach of children.
Formulated To Exclude:
Wheat, gluten, yeast, soy, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
References
1. Goffart S, Wiesner RJ. Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis. Exp Physiol. 2003 Jan;88(1):33-40. Review. [PMID: 12525853]
2. López-Lluch G, Irusta PM, Navas P, et al. Mitochondrial biogenesis and healthy aging. Exp Gerontol. 2008 Sep;43(9):813-9. Review. [PMID: 18662766]
3. Lanza IR, Short DK, Short KR, et al. Endurance exercise as a countermeasure for aging. Diabetes. 2008 Nov;57(11):2933-42. [PMID: 18716044]
4. Johnston AP, De Lisio M, Parise G. Resistance training, sarcopenia, and the mitochondrial theory of aging. Appl Physiol Nutr Metab. 2008 Feb;33(1):191-9. Review. [PMID: 18347672]
5. Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005;39:359-407. [PMID: 16285865]
6. Leone TC, Lehman JJ, Finck BN, et al. PGC-1alpha deficiency causes multisystem energy metabolic derangements: muscle dysfunction, abnormal weight control, and hepatic steatosis. PLoS Biol. 2005 Apr;3(4):e101. [PMID: 15760270]
7. Bian K, Doursout MF, Murad F. Vascular system: role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich). 2008 Apr;10(4):304-10. [PMID: 18401228]
8. Nisoli E, Carruba MO. Nitric oxide and mitochondrial biogenesis. J Cell Sci. 2006 Jul 15;119(Pt 14):2855-62. [PMID: 16825426]
9. Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos. 2006 Oct;34(10):1786- 92. [PMID: 16868069]
10. Teichert J, Kern J, Tritschler HJ, et al. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int J Clin Pharmacol Ther. 1998 Dec;36(12):625-8. [PMID: 9876998]
