XYMOGEN, NeuroActives BrainSustain™ 120 Capsules

Representing more than 30 years of neuroscience research, this unique encapsulated formula is designed to enhance brain performance and promote brain health. A key component of a complete program to ensure optimal brain function, NeuroActives^™ BrainSustain^™ improves the energy production of brain mitochondria and provides generous antioxidant support to combat the damaging effects of excess free radicals in the brain.*

Four capsules of NeuroActives BrainSustain provide the same amount of N-Acetyl-Cysteine, Phosphatidylserine, Acetyl-L-Carnitine, Alpha Lipoic Acid, Coenzyme Q10, and Glucoraphanin as one scoop of BrainSustain™ powder.

• Supports Enhancement of Brain Function*
• Supports Brain Health and Healthy Memory*
• Provides Generous Antioxidant Support to the Brain*
• Supplies Micronutrients to Support Neuronal Energy Production*

NeuroActives™ BrainSustain™ provides an array of micronutrients and antioxidants that are essential to the structure, metabolism, and function of the brain and nervous system. This neurosupportive formula provides a foundational approach to sustaining neurological activity and integrity.*

N-Acetyl-Cysteine (NAC) As a source of the conditionally essential amino acid cysteine, NAC is a precursor to one of the brain’s most important antioxidants—glutathione. NAC itself is an effective antioxidant and has been shown to reduce the formation of free radicals that can contribute to oxidative damage in the brain.*[1]

Phosphatidylserine A phospholipid that is highly concentrated in the brain, phosphatidylserine (PS) plays a key role in neuronal energy production and communication. Since very little PS is found in food, we must synthesize or supplement the amount we need for optimal brain health. Improvements in cognitive function and memory have been observed following supplementation with PS.[2-4] For some individuals, cognitive decline may be related to “age-related decline in nutrition,”[5] and early nutrition intervention may be warranted. NeuroActives BrainSustain contains safe-source PS from sunflower lecithin and contains no animal products.*

Acetyl-L-Carnitine (ALCAR) The ALCAR form of the amino acid L-carnitine is found to have multifaceted roles in neuroprotection.[6] It can cross the blood-brain barrier where it stabilizes cell membranes, acts as an effective antioxidant, and protects brain cells from toxic chemicals and stress-induced damage.[7-9] In addition, ALCAR enhances neuronal energy production, facilitates the transport of fuel and waste products into and out of mitochondria, and supports the production of acetylcholine, a neurotransmitter essential to the processes of learning and concentration.*[8-10]

Alpha-Lipoic Acid Acting as both a fat- and water-soluble antioxidant, alpha-lipoic acid provides intracellular and extracellular protection against oxidative stress. With its low molecular weight, alpha-lipoic acid is easily absorbed in the gastrointestinal tract. It then enters circulation, crosses the blood-brain barrier, and reaches the brain where it can regenerate other important antioxidants, including glutathione, vitamin E, and vitamin C.*[11,12]

Coenzyme Q10 (CoQ10) As a ubiquinone, CoQ10 facilitates the transfer of electrons in the electron transport chain (ETC), playing a crucial role in the formation of ATP (adenosine triphosphate) and the generation of energy within the cell. CoQ10 also donates electrons, making it an effective antioxidant. As such, CoQ10 protects cells, cell membranes, and tissues from damaging free radicals and prooxidants. The antioxidant activity of CoQ10 may protect the brain from the oxidative stress that is believed to be partially responsible for the degeneration of neuronal cells.*[13]

Broccoli Seed Extract The patented form of the phytochemical in broccoli called sulforaphane glucosinolate (SGS™) is a key ingredient in NeuroActives BrainSustain. Extensive research demonstrates that when SGS is broken down to sulforaphane (its active form), it safely and effectively upregulates the Nrf2 system, enhances antioxidant production, and activates vital phase II detoxification enzymes.[14,15] This process protects from common toxins and xenobiotics.*

Adequate antioxidant protection from ongoing free radical damage is crucial to maintaining the health and function of the cells and, hence, tissues and organs, especially the brain. Unbridled oxidative damage can lead to metabolic disruption and organ dysfunction over time. Antioxidant-promoting phytochemicals such as SGS are considered “lifespan essentials” because they assist in maintaining health throughout adult life.*[16]

Other Ingredients

Tricalcium phosphate, capsule (hypromellose and water), stearic acid, magnesium stearate, silica, and calcium silicate.

Directions

Take two to four capsules daily, or as directed by your healthcare professional.

Consult your healthcare professional before use. Individuals taking medication, especially cancer treatment, should discuss potential interactions with their healthcare professional.

Storage

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

References

1. Sansone RA, Sansone LA. Getting a knack for NAC: N-acetyl-cysteine. Innov Clin Neurosci. 2011 Jan;8(1):10-4. [PMID: 21311702]

2. Kato-Kataoka A, Sakai M, Ebina R, et al. Soybean-derived phosphatidylserine improves the memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-55. [PMID: 21103034]

3. Richter Y, Herzog Y, Cohen T, et al. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010 Nov 2;5:313-6. [PMID: 21103402]

4. Vakhapova V, Cohen T, Richter Y, et al. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord. 2010;29(5):467-74. [PMID: 20523044]

5. Suchy J, Chan A, Shea TB. Dietary supplementation with alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocholine, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to the murine brain and improves cognitive performance. Nutr Res. 2009 Jan;29(1):70-4. [PMID: 19185780]

6. Picconi B, Barone I, Pisani A, et al. Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine. Neuropharmacology. 2006 Jun;50(8):917-23. [PMID: 16500685]

7. Steffen V, Santiago M, de la Cruz CP, et al. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Hum Exp Toxicol. 1995 Nov;14(11):865-71. [PMID: 8588946]

8. Sorbi S, Forleo P, Fani C, et al. Double-blind, crossover, placebo-controlled clinical trial with L-acetylcarnitine in patients with degenerative cerebellar ataxia. Clin Neuropharmacol. 2000 Mar-Apr;23(2):114-8. [PMID: 10803803]

9. Jones LL, McDonald DA, Borum PR. Acylcarnitines: role in the brain. Prog Lipid Res. 2010 Jan;49(1):61-75. Review. [PMID: 19720082]

10. Kobayashi S, Iwamoto M, Kon K, et al. Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106. [PMID: 20590847]

11. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78. Review. [PMID: 8958163]

12. Liu J. An overview of the effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction. Neurochem Res. 2008 Jan;33(1):194-203. Review. [PMID: 17605107]

13. Mancuso M, Orsucci D, Volpi L, et al. Coenzyme Q10 in neuromuscular and neurodegenerative disorders. Curr Drug Targets. 2010 Jan;11(1):111-21. Review. [PMID: 20017723]

14. Ping Z, Liu W, Kang Z, et al. Sulforaphane protects brains against hypoxic-ischemic injury through the induction of Nrf2-dependent phase 2 enzyme. Brain Res. 2010 Jul 9;1343:178-85. [PMID: 20417626]

15. Vauzour D, Buonfiglio M, Corona G, et al. Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity by activating ERK1/2, Nrf-2, and the upregulation of detoxification enzymes. Mol Nutr Food Res. 2010 Apr;54(4):532-42. [PMID: 20166144]

16. Holst B, Williamson G. Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants. Curr Opin Biotechnol. 2008 Apr;19(2):73-82. [PMID: 18406129]