NeuroScience, Calm CP 60 Capsules

Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*

• Cortisol Health & Adrenal Support - Calm CP is designed for adrenal support, to lower cortisol and provide ingredients important for calm and rest.* This groundbreaking blend includes phosphatidylserine, banaba leaf standardized to 18% corosolic acid, glycine and a taurine supplement.
• Shown to Help Lower Cortisol for Women & Men - In a survey on the effectiveness of Calm CP, participants were prescreened for elevated cortisol levels. Calm CP was shown to reduce cortisol (mean daily cortisol) by 17%.*
• Stress Support - High stress has been linked to less healthy dietary behaviors and elevated bedtime cortisol levels are associated with increased abdominal fat.* Calm CP is designed to address body management and the stress response, in which Cortisol plays a major role.*
• Promote Peaceful Nights - Calm CP includes a glycine supplement: This amino acid neurotransmitter binds receptors that regulate temperature during the night.* Taurine helps the body's natural GABA levels function more efficiently. GABA offers calm support and is the primary inhibitory neurotransmitter in the brain that is important for restful nights.*
• Practitioner Trusted, Professional Grade - Trusted by thousands of healthcare professionals, NeuroScience formulates products of adrenal support supplements, brain support, and immune health supplements exclusively on peer-reviewed research.* All are USA-manufactured in a cGMP-compliant facility.*

Key ingredients:

• Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid): Corosolic acid selectively inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an enzyme that catalyzes the conversion of cortisone into cortisol (1,2).* In a randomized study, corosolic acid was shown to significantly lower blood glucose levels by 20-30% after two weeks (3).*
• Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions (4).* Phosphatidylserine is thought to interact with cell membranes to dampen hypothalamic signaling and regulate the stress response (5).*
• Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier (6).* Binds receptors that regulate temperature during sleep (7).*
• Taurine: Neuro-protective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (8-10).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (11-13).

Supplement Facts:

Serving Size: 2 Capsules
Servings Per Container: 30

Amount Per Serving:

† Daily Value not established.

Suggested Use:

Take 2 capsules one to two times daily or as directed by your healthcare provider.

Other Ingredients:

Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, Magnesium stearate (vegetable source), and Silicon dioxide.

Notes/Warnings:

If you are pregnant or nursing, consult your healthcare provider before use. Contains lecithin from soy.

*The Food and Drug Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure, or prevent any disease.

References:
1. Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15.
2. Patel H, et al. Arabian Journal of Chemistry. 2015.
3. Judy W, et al. J Ethnopharmacol. 2003;87(1):115-7.
4. Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8.
5. Glade M and Smith K. Nutrition. 2015;31(6):781-6.
6. Kawai N, et al. Amino Acids. 2012;42(6):2129-37.
7. Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
8. Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
9. Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
10. Kletke O, et al. PLoS One. 2013;8(4):e61733.
11. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
12. Mohler H. Neuropharmacology. 2012;62(1):42-53.
13. Saper C, et al. Nature. 2005;437(7063):1257-63.