XYMOGEN, OptiCleanse GHI Vanilla Delight Sugar & Stevia-Free 10 Servings
OptiCleanse® GHI Sugar- and Stevia-Free‡ is a comprehensive, fructose-free, low-allergy–potential dietary supplement designed to support gastrointestinal (GI) function and balanced detoxification. It features VegaPro™, XYMOGEN’s proprietary amino acid and pea/rice protein blend; Aminogen®, to facilitate protein absorption; phytonutrients; mineral amino acid chelates; and activated B vitamins, including Quatrefolic® and methylcobalamin. In conjunction with a modified elimination diet, OptiCleanse GHI Sugar- and Stevia-Free‡ addresses GI and hepatic function as well as eicosanoid balance and cytokine metabolism. This formula is suitable for vegans.*
‡This formula is not a low-calorie dietary supplement. Please see the Supplement Facts panel for more details.
- Supports Natural Detoxification Mechanisms*
- Supports Gastrointestinal Health*
- Supports a Balanced Cytokine Profile*
- Lactose-Free Vegan Protein Source*
OptiCleanse® GHI Sugar- & Stevia-Free‡ is now sweetened with a natural sweetener extracted from monk fruit. This generally recognized as safe (GRAS) monk-fruit extract offers a high-quality sweetness and flavor without the bitter aftertaste associated with some natural sweeteners.
Like XYMOGEN’s other OptiCleanse GHI formulas, OptiCleanse® GHI Sugar- & Stevia-Free‡ contains macro- and micronutrients, as well as a host of ingredients (some patented or proprietary) that support fatty acid metabolism, gastrointestinal health, and healthy eicosanoid and cytokine metabolism. Activated cofactors support mitochondrial energy production needed for biotransformation and detoxification. This formula’s ingredients help moderate phase I detoxification, upregulate and support phase II pathways, and provide antioxidant support as well.*
Protein Metabolism
VegaPro™ is XYMOGEN’s proprietary blend of pea protein isolate and rice protein concentrate, L-glutamine, glycine, and taurine. Generation of glutathione and sulfation cofactors—vital for phase II conjugation—requires an array of amino acids. The combination of pea protein and rice protein, containing a complement of amino acids, achieves an amino acid score of 100%. Glutamine, a conditionally essential and versatile amino acid with 2 nitrogen moieties, is crucial to nitrogen metabolism and helps maintain healthy liver tissue and function.1,2 The amino acid glycine is needed for bile synthesis, phase II detoxification, and glutathione production. Taurine, a derivative of the sulfur-containing amino acid cysteine, is also important for the synthesis of bile salts and helps stabilize cell membranes.*
Gastrointestinal Support
Ginger root, included to support healthy digestion, such as the release of bile from the gallbladder, acts at several sites to moderate PGE(2) production and support the normal response to inflammation.3 Fiber (from inulin and flaxseeds) supports the production of short-chain fatty acids as well as a healthy intestinal flora. Milled Golden Flaxseed, provided in full-fat, non-GMO form, possesses excellent oxidative stability, supports antioxidant activity, and provides lignins, soluble fiber, and omega-3 and omega-6 essential fatty acids.4 The flaxseed is extensively milled, which provides a smoother mouthfeel and less grit than earlier versions of OptiCleanse formulas. Glutamine plays a key role in healthy intestinal cell proliferation and gut barrier integrity, immune function, and normal tissue healing.1,2*
Detoxification Support
Green tea catechins not only support antioxidant activity but also appear to act as modulators of phase I and phase II detoxification.5 Choline is present to support lipid metabolism in the liver and can be converted to betaine, a methyl donor.6 *
In OptiCleanse GHI, folate is provided as Quatrefolic® ([6S]-5-methyltetrahydrofolic acid, glucosamine salt) because of its enhanced stability, solubility, and bioavailability.7 * Quatrefolic combined with active, bioavailable forms of B vitamins, including pyridoxal-5’-phosphate (B6), [6S]-5-methyltetrahydrofolate (5-MTHF; B9), and methylcobalamin (B12), and glycine all support amino acid conjugation and are vital for the detoxification of xenobiotics and xenoestrogens. 5-MTHF, methylcobalamin, betaine, and methylsulfonylmethane (MSM) are present to support methylation and detoxification. 5-MTHF supports healthy folate nutrition, especially in individuals with variations in folate metabolism.
Preventium®, a patented form of potassium D-glucarate, supports glucuronidation. Sulfation is supported by MSM and sodium sulfate. Acetylation is supported by D-calcium pantothenate, pyridoxal-5’-phosphate, and magnesium. Several minerals in OptiCleanse GHI are provided as Albion® mineral amino acid chelates for enhanced gastrointestinal absorption and bioavailability.8 *
Antioxidant Support and Cytokine Balance
Bioflavonoids, quercetin, rutin, and curcumin support antioxidant activity, counter free radicals and support healthy eicosanoid and cytokine metabolism.9,10 Curcumin has a long history of use for its support of a normal, healthy response to inflammation.11 N-acetyl-cysteine (NAC) stimulates glutathione synthesis, enhances glutathione-S-transferase activity, and promotes detoxification.12 Selenium glycinate provides support for glutathione metabolism and antioxidant protection.*
Other Ingredients
Sunflower oil, natural flavors (no MSG), medium-chain triglyceride oil, taurine, glycine, cellulose gum, xanthan gum, fungal proteasesS5, L-glutamine, monk fruit extract, guar gum, and silica.
Directions
Blend, shake, or briskly stir the contents of one packet (53 g) into 10-12 ounces of chilled, pure water (or mix amount for desired thickness) and consume once daily, or use as directed by your healthcare professional.
Consult your healthcare professional before use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use it if the tamper seal is damaged.
Storage
Store in a cool, dry place out of reach of children.
Formulated To Exclude
Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.
‡ This formula is not a low-calorie dietary supplement. Please see the Supplement Facts panel for more details.
Also available in Chai and Creamy Chocolate.
References
1. Smith RJ, Wilmore DW. Glutamine nutrition and requirements. JPEN J Parenter Enteral Nutr. 1990 Jul-Aug;14(4 Suppl):94S-99S. Review. [PMID: 2119461]
2. Lacey JM, Wilmore DW. Is glutamine a conditionally essential amino acid? Nutr Rev. 1990 Aug;48(8):297-309. Review. [PMID: 2080048]
3. Lantz RC, Chen GJ, Sarihan M, et al. The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine. 2007 Feb;14(2-3):123- 28. [PMID: 16709450]
4. Adolphe JL, Whiting SJ, Juurlink BH, Thorpe LU, Alcorn J. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr. 2010 Apr;103(7):929-38. Review. [PMID: 20003621]
5. Akhlaghi M, Bandy B. Dietary green tea extract increases phase 2 enzyme activities in protecting against myocardial ischemia-reperfusion. Nutr Res. 2010 Jan;30(1):32-39. [PMID: 20116658]
6. Linus Pauling Institute. http://lpi.oregonstate.edu/infocenter/othernuts/choline/. Accessed May 8, 2012.
7. Quatrefolic. http://www.quatrefolic.com/. Accessed May 8, 2012.
8. Albion. http://www.albionminerals.com/. Accessed May 8, 2012.
9. Garg R, Gupta S, Maru GB. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis. 2008 May;29(5):1022- 32. [PMID: 18321868]
10. Amália PM, Possa MN, Augusto MC, et al. Quercetin prevents oxidative stress in cirrhotic rats. Dig Dis Sci. 2007 Oct;52(10):2616-21. [PMID: 17431769]
11. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53. [PMID: 19594223]
12. Kelly GS. Clinical applications of N-acetylcysteine. Altern Med Rev. 1998 Apr;3(2):114-27. Review. [PMID: 9577247]