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Professional Supplements & Nutritional Products Since 1998

OptiCleanse® Plus provides macro- and micronutrients that support all phases of biotransformation and detoxification; these nutrients also support the mitochondrial energy production necessary to complete this vital function. OptiCleanse Plus is easy to digest and has a low-allergy potential, a pleasant taste, and no added fructose. OptiCleanse Plus features VegaPro™, XYMOGEN’s proprietary pea/rice protein blend; Aminogen®, to facilitate protein absorption; activated B vitamins, such as riboflavin 5’-phosphate (B2), pyridoxal 5’-phosphate (B6), 5-methyltetrahydrofolate (folate), and methylcobalamin (B12); and Albion’s patented TRAACS® mineral amino acid chelates. 5-methyltetrahydrofolate (5-MTHF) is provided as Quatrefolic®, a stable, bioavailable form of folate. In conjunction with a modified elimination diet, OptiCleanse Plus not only addresses healthy detoxification but also supports energy generation. This formula is suitable for vegans.*

  • Supports Natural Detoxification Mechanisms*
  • Supports Healthy Hormone Metabolism*
  • Provides High-Quality Macro- and Micronutrients*

OptiCleanse® PLUS represents an advanced, comprehensive approach to supporting the body’s detoxification processes. The provision of high-quality, easy-to-digest protein with the addition of amino acids, micronutrients, essential fatty acids, and metabolic cofactors makes OptiCleanse PLUS an indispensable adjunct to an effective detoxification program.*

VegaPro™ is XYMOGEN’s proprietary blend of pea protein isolate and rice protein concentrate plus L-glutamine, L-glycine, and taurine. The generation of glutathione and sulfation cofactors necessary for phase II conjugation requires an array of amino acids. The combination of pea protein and rice protein provides a non-GMO protein source that is easily digested and achieves an amino acid score of 100% (a measure of how efficiently a protein meets the protein synthesis needs of children and adults). VegaPro does not contain milk, soy, wheat, corn, or animal-based protein.*

OptiCleanse PLUS contains 24 grams of protein per serving—the equivalent of approximately three-and-a-half ounces of dietary protein derived from sources such as poultry or fish. Dietary protein is essential for building and maintaining lean body mass, hormones, and neurotransmitters. Protein is also essential for the biosynthesis of metabolically active tripeptides, such as glutathione, a key factor in the detoxification of exogenous and endogenous toxins. Overall protein energy metabolism affects phase II detoxification reactions as well as the activity of cytochrome P450 enzymes, the enzymes which detoxify environmental chemicals and drugs.*[1]

Vitamins and Minerals Adequate biotransformation depends upon the mitochondrial generation of ATP, which requires several nutrient cofactors, including thiamin, riboflavin, niacin, pantothenic acid, and magnesium. Minerals, such as selenium, copper, zinc, and manganese, along with vitamins A, C, and E, support antioxidant mechanisms that counteract the reactive oxygen species (intermediary metabolites) that occur between phase I and phase II detoxification. N-acetyl-cysteine supports the production of glutathione, which is also provided intact in OptiCleanse PLUS.*

Specific ingredients that support phase II pathways comprise the activated, readily available form of B vitamins, including 5-methyltetrahydrofolate (folate), methylcobalamin (B12), and pyridoxal 5’-phosphate (B6) for methylation; Preventium® (a patented form of potassium D-glucarate) for glucuronidation; N-acetyl-cysteine for sulfation; and D-calcium pantothenate, pyridoxal 5’-phosphate, and magnesium for acetylation.[2-7] 5-methyltetrahydrofolate (5-MTHF) is provided as Quatrefolic®, which has greater stability, solubility, and bioavailability than calcium salt forms. Using science and patented technology, the formula’s pharmaceutical-grade inorganic minerals have been transformed into mineral amino acid chelates for enhanced absorption by the body. XYMOGEN has earned, and OptiCleanse PLUS proudly bears the Albion Gold Seal.*

Milled Golden Flaxseed is provided in full-fat, stabilized, non-GMO form. Flaxseed is found to be the most abundant source of the lignan SDG (secoisolariciresinol diglucoside). Metabolites of SDG are closely studied for their roles in supporting healthy hormone metabolism, detoxification, antioxidant mechanisms, and maintenance of normal lipid and glucose levels.[8] Flaxseed is also a source of the essential omega-3 fatty acid alpha-linolenic acid as well as soluble fiber, vitamins, minerals, and the essential omega-6 fatty acid, linoleic acid.*

OptiCleanse PLUS is comprehensive micronutrient and detoxification support that provides significant flaxseed lignan content to promote healthy hormone metabolism.*

Other Ingredients

Sunflower oil, natural flavors (no MSG), medium-chain triglyceride oil, cellulose gum, xanthan gum, taurine, glycine, fungal proteasesS4, L-glutamine, guar gum, monk fruit extract, and silica.


Blend, shake, or briskly stir the contents of one packet (54 g) into 10-12 oz chilled water and consume once daily, or as directed by your healthcare professional. Adjust the amount of water to the desired sweetness and thickness.

Consult your healthcare professional before use. Individuals taking medication should discuss potential interactions with their healthcare professional.


Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude

Wheat, gluten, yeast, soy protein, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.


1. Wu G, Fang YZ, Yang S, et al. Glutathione metabolism and its health implications. J Nutr. 2004 Mar;134(3):489-92. [PMID: 14988435]]

2. Brosnan JT, et al. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. [PMID: 15218538]

3. Levy G. Sulfate conjugation in drug metabolism: role of inorganic sulfate. Fed Proc. 1986 Jul;45(8):2235-40. [PMID: 3459670]

4. Zółtaszek R. The biological role of D-glucaric acid and its derivatives: potential use in medicine [in Polish]. Postepy Hig Med Dosw (Online). 2008 Sep 5;62:451-62. [PMID: 18772850]

5. Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, et al. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci. 2006 Apr;27(5):447-86. [PMID: 16472997]

6. Baker SM, Bennett P, Bland JS, et al. Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine; 2010.

7. Shils ME, Shike MS, Ross AC, et al. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Williams & Wilkins; 2005.

8. Adolphe JL, Whiting SJ, Juurlink BH, et al. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr. 2010 Apr;103(7):929- 38. [PMID: 20003621]

9. Turczynowski W, Szczepanik AM, Garlicki J, et al. Glutamine--its metabolic role and possibilities for clinical use [in Polish]. Przegl Lek. 1998;55(12):659-62. Review. [PMID: 10354717]

10. Wang WW, Qiao SY, Li DF. Amino acids and gut function. Amino Acids. 2009 May;37(1):105-10. Review. [PMID: 18670730]

11. Wischmeyer PE. Glutamine: role in critical illness and ongoing clinical trials. Curr Opin Gastroenterol. 2008 Mar;24(2):190-7. Review. [PMID: 18301270]