Advanced Spore-Based Probiotic
Three sequenced spore strains, one prebiotic, one dose a day.
CoreBiotic® delivers three genomically-sequenced spore strains plus VitaFiber® prebiotic, 11 billion CFU in a single daily dose, to support a healthy microbiome.* Because the strains are spore-forming, they survive stomach and bile acids and need no refrigeration.
Advanced Spore-Based Probiotic
Researched Nutritionals CoreBiotic® · 60 Capsules
Modern processed diets stripped out the soil-based organisms your microbiome once got from food, and a balanced microbiome is central to your immune and whole-body health.* CoreBiotic delivers three genomically-sequenced spore strains plus VitaFiber prebiotic, 11 billion CFU in a single daily dose, to support a healthy microbiome.* Because the strains are spore-forming, they survive stomach and bile acids, need no refrigeration, and arrive where they go to work, all from one capsule pair a day.*
- Vegan
- Gluten-Free
- Dairy-Free
- GMO-Free
- No Refrigeration
- 1 dose/day
- ✓11 Billion CFU + Prebiotic per daily dose (2 capsules)
- ✓3 genomically-sequenced spore strains + Organic VitaFiber® prebiotic
- ✓60 capsules = 30-day supply
- ✓Take 2 capsules once daily, 30 minutes before eating
Discount applies automatically at checkout. No code needed.
Take 2 capsules once daily, 30 minutes before eating. No refrigeration needed.
- Authorized Researched Nutritionals reseller
- Shelf-stable, no refrigeration
- Vegan & gluten-free
In stock and ships from an authorized retailer of Researched Nutritionals®. 30-day returns on unopened items.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
Why your microbiome needs help it didn't used to
Your food used to seed your gut. Today it mostly doesn't.
For most of human history, eating organic produce straight from the soil meant you also swallowed soil-based organisms, the spore-forming microbes that helped maintain a normal microbiome in the intestines.* That was the default, built into every meal.
Modern eating broke that loop. Processed foods, and produce carrying pesticide and hormone residues, mean most people no longer take in those beneficial soil-based organisms. The result is a microbiome with less of the diversity it evolved to rely on.
And that matters more than digestion alone. Your microbiome is a diverse, metabolically active community that interacts continuously with your own genome, which makes it an integral part of how your immune system supports a healthy inflammation response.* Managing the gut microbiome is foundational to supporting positive long-term health.*
- ✓A healthy immune system requires a healthy microbiome.*
- ✓Soil-based organisms were once a normal part of eating whole food.
- ✓11 billion CFU per dose, from strains chosen for their published research.
What an out-of-balance microbiome feels like
When the balance slips, you tend to notice it.
A microbiome that has lost diversity isn't something you can see. You feel it, in small daily ways that are easy to write off as just how things are now.
- ✓Digestive comfort that feels less predictable than it used to, day to day.
- ✓Less of the day-to-day resilience you want from your immune response, especially through busy or stressful stretches.
- ✓A general sense that your gut isn't keeping up with how you eat and live.
- ✓Trying probiotic after probiotic and wondering whether any of it is reaching where it needs to.
Most ordinary probiotics share one quiet problem: many of those organisms don't survive the trip through stomach and bile acids in the first place. Which raises the real question, what actually makes it through?
Meet CoreBiotic
Three sequenced spore strains, one prebiotic, one dose a day.
CoreBiotic was built around a simple idea: put back the soil-based organisms modern food left out, and choose strains precise enough to count on.
It combines three fully sequenced and registered spore-based probiotics with VitaFiber® prebiotic to support a healthy microbiome.* Each strain was specifically chosen for its mechanisms of action, as supported by published research, not picked from a general group and hoped for.
- ✓Advanced. 3 spore-forming strains, each genomically sequenced and registered to guarantee accurate specificity and potency.
- ✓Comprehensive. Each strain chosen for its published research covering intestinal health and beyond.
- ✓Microbiome support. 11 billion CFU per dose.*
- ✓Convenient. 1 dose per day, no refrigeration, and competitively priced.
Advanced, comprehensive microbiome support.*
Why spore-based changes everything
Spores survive the journey. That's the whole point.
Most probiotics fail before they begin, broken down by stomach and bile acids long before they reach the intestines. Spore-forming probiotics are different by design.
- They survive the trip. Because soil-based organisms are spore-forming, they are heat-stable, dairy-free, and able to withstand stomach and bile acids, passing into the intestines without degradation.*
- They activate where it counts. Once in the intestines, they leave the spore form and produce lactic acid, which has natural antibacterial properties that help discourage the growth of less desirable bacteria.*
- They earn their space. Through this competitive inhibition, the beneficial probiotic bacteria are helped to proliferate and hold their place in the microbiome.*
- The prebiotic feeds them. VitaFiber® prebiotic gives those organisms the fuel they need once they arrive.*
The genomic-sequencing edge
Probiotic formulation has moved past listing general groups of organisms. Older formulas might say "Bacillus subtilis" with no strain number at all. CoreBiotic includes only probiotics identified by genomic sequencing and registered with a specific strain number, the strains that have undergone rigorous genomic studies, so specificity and potency are accurate, not approximate.
"Protection in transit, activation on arrival."
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
CoreBiotic vs ordinary probiotics
Not all probiotics make it past your stomach.
| CoreBiotic® | Ordinary / Refrigerated Probiotics | |
|---|---|---|
| Survives stomach acid & bile | Yes, spore-based strains shielded to reach the intestine | Many fragile strains degrade before arrival |
| Genomically sequenced & researched strains | Yes, every strain ID'd (BCP92, MTCC 5856, DE111®) | Often generic strains, no strain-level ID |
| Built-in prebiotic | Yes, Organic VitaFiber® 660 mg feeds the strains | Usually probiotic only, no fuel source |
| Shelf-stable / no refrigeration | Yes, stays viable at room temperature | Many require cold-chain & fridge storage |
| Vegan & allergen-conscious | Yes, vegan, dairy-free, gluten-free, non-GMO | Frequently dairy-derived |
| Dosing convenience | 1 dose/day (2 caps), 11B CFU + prebiotic | Often multiple capsules, multiple times daily |
Comparison reflects CoreBiotic's label and formulation characteristics vs. common probiotic formats. Individual results vary.
See why people switch from fragile probiotics.
Survives the trip. Shelf-stable. One dose a day.
Choose your supply →Every milligram, on the label
What's in each daily dose (2 capsules).
No proprietary mystery. Here is exactly what two capsules deliver, straight from the Supplement Facts.
| Ingredient | Amount per 2-capsule dose | Role |
|---|---|---|
| Total Carbohydrates | 1 g (<1% DV) | — |
| Organic VitaFiber® (Isomalto-oligosaccharide Mixture) | 660 mg | Prebiotic, feeds the beneficial organisms |
| CB Complex | 96 mg · 11 Billion CFU | Spore-based probiotic blend (3 strains below) |
| ↳ Bacillus coagulans (BCP92) | part of CB Complex | Genomically sequenced spore strain |
| ↳ Lactospore® Bacillus coagulans (MTCC 5856) | part of CB Complex | Genomically sequenced spore strain |
| ↳ Bacillus subtilis (DE111®) | part of CB Complex | Genomically sequenced spore strain |
Other ingredients: Capsule shell (hypromellose, water), rice maltodextrin, medium chain triglycerides.
Allergen statement: Manufactured without milk, eggs, fish, crustacean shellfish, peanuts, sesame, wheat, soy and gluten. Manufactured in a facility that may process other ingredients containing these allergens.
Supplement Facts, straight from the label.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Every strain, genomically verified.
Registered strain numbers, not a generic group. 11 billion CFU per dose.
Add to Cart →Simple by design
Two capsules, once a day, 30 minutes before you eat.
- Take 2 capsules once daily. That's your full 11 billion CFU dose.
- Time it 30 minutes before eating. Taking it on a relatively empty stomach is the suggested window.
- Store it anywhere cool and dry. No refrigeration required, so it travels and lives on the shelf.
- Pair it with a fiber-rich diet. Whole, fiber-rich foods give your microbiome more to work with alongside the VitaFiber prebiotic.
Supply note: 60 capsules at 2 per day is a 30-day supply.
Why customers keep reaching for it
Trusted by people who read the label first.
CoreBiotic has earned an average of 4.9 out of 5 stars across 25 reviews, the kind of rating that tends to come from people who care about what they put in their body and check the strain numbers before they buy.
- ★4.9 average across 25 reviews
- ✓Genomically-sequenced, registered strains, full transparency on the label
- ✓Shelf-stable and travel-friendly, no cold chain to manage
- ✓Vegan, dairy-free, gluten-free, GMO-free
- ✓Sold by Agape Nutrition, an authorized reseller of Researched Nutritionals
Join the customers who rated CoreBiotic 4.9 stars.
25 reviews. 4.9 average. One daily dose.
Start your 30-day supply →Our return policy, plainly stated
30-day returns on unopened items.
We want you to buy with clarity, so here is exactly how returns work. Unopened items can be returned within 30 days of purchase. Because this is a consumable health product, opened items can't be returned for safety reasons. Returns are subject to a 15% restocking fee, original shipping is non-refundable, and an RMA form is required to start a return.
No guesswork on the policy. Just the straight terms, before you order.
Authorized reseller, genuine product. 30-day returns on unopened items. RMA required. Opened items are non-returnable.
- ✓Authorized reseller, genuine product
- ✓Genomic-sequenced strains, verified identity
- ✓Shelf-stable, no cold-chain risk
- ★4.9★ from 25 customers
New to CoreBiotic? Start with one bottle.
30-day returns on unopened items. Discount applies automatically at 2+.
Try a single bottle →What buyers are saying
4.9 stars across 25 reviews.
★★★★★ 4.9 average · 25 verified reviews
4.9 stars from 25 real customers.
Spore-based. Sequenced strains. Shelf-stable.
Get CoreBiotic →Good questions, straight answers
Everything people ask before their first bottle.
Is CoreBiotic GMO-free?
Yes. CoreBiotic is GMO-free.
Does CoreBiotic need to be refrigerated?
No. There is no need to refrigerate CoreBiotic. Because the probiotics are spore-forming and heat-stable, it stays shelf-stable at room temperature, which also makes it easy to travel with.
Is CoreBiotic gluten-free?
Yes. CoreBiotic is gluten-free. It is also manufactured without milk, eggs, fish, crustacean shellfish, peanuts, sesame, wheat, soy and gluten, in a facility that may process other ingredients containing these allergens.
How do I take it, and when?
Take 2 capsules once daily, at least 30 minutes before eating. Two capsules is one full 11 billion CFU dose.
How long does one bottle last?
Each bottle holds 60 capsules. At 2 capsules per day, that's a 30-day supply.
Is CoreBiotic vegan and dairy-free?
Yes. CoreBiotic is vegan and dairy-free, along with being gluten-free and GMO-free.
What makes spore-based probiotics different from regular probiotics?
Many ordinary probiotics break down in stomach and bile acids before reaching the intestines. Spore-based probiotics, also known as soil-based organisms, are spore-forming and able to withstand those acids, so they pass into the intestines intact before activating. They're also heat-stable, which is why CoreBiotic needs no refrigeration.
Why does genomic sequencing matter?
Older probiotic formulas often listed a general organism like "Bacillus subtilis" with no strain number. CoreBiotic uses only strains identified by genomic sequencing and registered with a specific strain number, so the specificity and potency on the label are accurate.
Still deciding? Your microbiome isn't waiting.
One dose a day. 5% off 2, 10% off 3+, applied automatically.
Order now →The science behind spore-based probiotics
Built on the published research behind spore-based probiotics.
The ingredients in CoreBiotic® were selected based on published research into spore-forming probiotic organisms, genomic strain identification, and prebiotic synergy. The references below support the general structure and function science behind this category. They are provided for education and substantiation and do not represent claims that this product treats, cures, or prevents any disease.
- Cutting SM. Bacillus probiotics. Food Microbiology. 2011;28(2):214-220.
- Bernardeau M, et al. Importance of the gastrointestinal life cycle of Bacillus for probiotic functionality. J Food Sci Technol. 2017;54(8):2570-2584.
- Majeed M, et al. Bacillus coagulans MTCC 5856 (LactoSpore®) supplementation: a double-blind randomized placebo-controlled study. Nutrition Journal. 2016;15:21.
- Cuentas AM, et al. The effect of Bacillus subtilis DE111 on the daily bowel movement profile. J Probiotics Health. 2017;5:189.
- Colom J, et al. Presence and germination of the probiotic Bacillus subtilis DE111 in the human small intestinal tract. Front Microbiol. 2021;12:715863.
- Gibson GR, et al. ISAPP consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
Round out your gut-support routine
Build your complete gut protocol.
Customers pair CoreBiotic with these to support the whole microbiome terrain.
CoreBiotic® Sensitive · 60 Caps
Low-FODMAP sibling for more sensitive systems.
Multi-Biome™ · 30 Caps
Broader multi-strain support for the microbiome.
RenewGut™ · 120 Caps
Gut-lining and terrain support to round out the regimen.