XYMOGEN, Bio C 1:1™ 90 Capsules

XYMOGEN®

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Immune Health

Bio C 1:1™ combines high-potency vitamin C with a standardized, full-spectrum, citrus bioflavonoid complex. Both vitamin C and bioflavonoids have been extensively researched for their roles in supporting antioxidant and immune function. In addition, research indicates that vitamin C is required for the synthesis of collagen, neurotransmitters, and carnitine. Bioflavonoids...
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Bio C 1:1™ combines high-potency vitamin C with a standardized, full-spectrum, citrus bioflavonoid complex. Both vitamin C and bioflavonoids have been extensively researched for their roles in supporting antioxidant and immune function. In addition, research indicates that vitamin C is required for the synthesis of collagen, neurotransmitters, and carnitine. Bioflavonoids appear to support healthy metabolism and cognition by functioning as cell-signaling agents.*

  • Antioxidant support*
  • Healthy Connective Tissue and Blood Vessel Synthesis*
  • Support of Normal Immune System Function*
  • Synthesis of Carnitine, Neurotransmitters, and Collagen*

 

Bio C 1:1 is formulated to provide antioxidant protection, enhance immune function, and support the synthesis and function of collagen, carnitine, and neurotransmitters. Each capsule of Bio C 1:1 provides 500 mg of vitamin C and 500 mg of citrus bioflavonoid complex in a one-to-one ratio.*

Vitamin C (ascorbic acid) is a water-soluble antioxidant vitamin that is essential to humans. While most mammals are able to synthesize vitamin C, humans must obtain it exogenously. Stress, smoking, pollution, radiation and heavy metal exposure, immune challenge, and temperature change all increase the human requirement for vitamin C.[1] Well-known functions of this ubiquitous vitamin include antioxidant protection from free radicals and oxidative processes; synthesis of collagen, carnitine, and neurotransmitters; adrenal support; and immune stimulation and support.[2-4] Vitamin C serves as a cofactor for several metabolic enzymes, including hydroxylase and oxygenase (hydroxylation reactions).*[5]

Vitamin C has long been recognized for its contribution to immune support.[3] Immune cells absorb and concentrate vitamin C. Immune cell activity, particularly T-cell function and phagocytosis, is found to be enhanced by this essential vitamin.[6-7] In early 1972, a randomized, double-blind, placebo-controlled study of 1000 subjects taking 1000 mg of vitamin C per day provided support for the use of vitamin C supplementation for common immune challenges. The study results revealed that the supplementation group missed significantly fewer days from work/activities and had fewer days per episode of the immune challenge; in addition, significantly more subjects taking vitamin C remained symptom-free throughout the study.[8] The optimal intake of vitamin C for humans continues to be debated, though normal vitamin C synthesis in mammals such as rats is calculated to be 26-58 mg/ kg/day. Dr. Linus Pauling, in his 1970 article on evolution and vitamin C requirements, recommended a minimum intake of 2300 mg per 2500 kilocalorie intake per day for humans.*[9]

Vitamin C has far-reaching effects on a number of tissues in the body because it is required for the synthesis of collagen.[4] Collagen is a fundamental component of bones, tendons, ligaments, blood vessels, skin, gums, and joints. Ultimately, the health of these tissues depends on vitamin C. Energy generation from fatty acids is vitamin C-dependent as well since the synthesis of carnitine (the molecule that shuttles long-chain fatty acids into the mitochondria) requires this versatile vitamin. Vitamin C is maintained in relatively high concentrations in the brain; it is essential to maintaining healthy mood and brain function because it facilitates the conversion of dopamine to norepinephrine and enhances interneuronal communication.*[10]

Bioflavonoids (also known as flavonoids) are phytochemicals that are often found together with vitamin C in nature and are generally considered to be among the most important and interesting classes of biologically active compounds in contemporary research. More than 4000 bioflavonoids have been identified. Intake of flavonoids is associated with healthy cardiovascular status, the body’s normal response to inflammation, and positive microbial balance.*[11,12]

Citrus bioflavonoids are commonly used in Europe for blood vessel and lymph system support. US practitioners utilize bioflavonoids in protocols to support tissue and joint comfort and the body’s normal response to inflammation,[13-15] respiratory [16,17] and eye health,[18] and maintenance of cardiovascular health.[19-21] Citrus bioflavonoids are able to cross the blood-brain barrier and have been recognized for their neuroprotective effects.[22] As cell-signaling agents, bioflavonoids are believed to support healthy cell growth and normal cell-life regulation, stimulate detoxification enzymes, decrease vascular cell adhesion molecules, increase vasodilation, and support healthy platelet function.*[23]

The combination of vitamin C and citrus bioflavonoids in Bio C 1:1 ensures that a wide range of metabolic functions will be supported.*

Other Ingredients:

Capsule (hypromellose and water), stearic acid, magnesium stearate, medium-chain triglyceride oil, and silica.

Directions:

Take one capsule daily, or as directed by your healthcare professional. Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professionals. Do not use it if the tamper seal is damaged.

Storage:

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, ingredients derived from genetically modified organisms, artificial colors, artificial sweeteners, and artificial preservatives.

References:

  1. Whitney EN, Rolfes SR. Understanding Nutrition. 8th ed. Belmont, CA: Wadsworth; 1998:321.
  2. NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin C. http://ods. od.nih.gov/factsheets/VitaminC-HealthProfessional/. Accessed December 10, 2012.
  3. Schlueter AK, Johnston CS. Vitamin C: overview and update. Journal of Evidence-Based Complementary & Alternative Medicine (JEBCAM). 2011; 16(1):49-57. http://chp. sagepub.com/content/16/1/49.full.pdf+html. Accessed December 10, 2012.
  4. Linus Pauling Institute. Vitamin C. http://lpi.oregonstate.edu/infocenter/vitamins/vitaminC/. Updated November 2009. Accessed December 10, 2012.
  5. Naidu KA. Vitamin C in human health and disease is still a mystery. An overview. Nutr J. 2003 Aug 21;2:7. [PMID: 14498993]
  6. Chatterjee M, Dikshit M. Vitamin C mediated resistance to pathogenic invasions: possible implications during infections for better health. Proceedings of the National Academy of Sciences India. Section B, Biological Sciences. 2009; 79(1):15-25.
  7. Ströhle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection—ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Inflamm Allergy Drug Targets. 2011 Feb;10(1):54-63. [PMID: 21184650]
  8. Anderson TW, Reid DB, Beaton GH. Vitamin C and the common cold: a double-blind trial. Can Med Assoc J. 1972 Sep 23;107(6):503-8. [PMID: 5057006]
  9. Pauling L. Evolution and the need for ascorbic acid. Proc Natl Acad Sci USA. 1970 Dec;67(4):1643-8. [PMID: 5275366]
  10. Rebec GV, Pierce RC. Vitamin as a neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission. Prog Neurobiol. 1994 Aug;43(6):537-65. Review. [PMID: 7816935]
  11. Tripoli E, La Guardia M, Giammanco S, et al. Citrus flavonoids: Molecular structure, biological activity, and nutritional properties: A review. Food Chemistry. 2007; 104(2):466- 79.
  12. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000 Dec;52(4):673-751. Review. [PMID: 11121513]
  13. Guardia T, Rotelli AE, Juarez AO, et al. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rats. Farmaco. 2001 Sep;56(9):683-7. [PMID: 11680812]
  14. Rotelli AE, Guardia T, Juárez AO, et al. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res. 2003 Dec;48(6):601-6. [PMID: 14527825]
  15. Lin N, Sato T, Takayama Y, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol. 2003 Jun 15;65(12):2065-71. [PMID: 12787887]
  16. Pijnenburg MW, Hofhuis W, Hop WC, et al. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax. 2005 Mar; 60(3):215-8. [PMID: 15741438]
  17. Lee NK, Choi SH, Park SH, et al. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology. 2004 Aug;71(4):174-80. [PMID: 15240993]
  18. Majumdar S, Srirangam R. Potential of the bioflavonoids in the prevention/treatment of ocular disorders. J Pharm Pharmacol. 2010 Aug;62(8):951-65. Review. [PMID: 20663029]
  19. Wright B, Spencer JP, Lovegrove JA, et al. Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs. Cardiovasc Res. 2012 Nov 1. [Epub ahead of print] [PMID: 23024269]
  20. Mulvihill EE, Huff MW. Citrus flavonoids and the prevention of atherosclerosis. Cardiovasc Hematol Disord Drug Targets. 2012 Oct 1. [Epub ahead of print] [PMID: 23030447]
  21. Soory M. Nutritional antioxidants and their applications in cardiometabolic diseases. Infect Disord Drug Targets. 2012 Nov 16. [Epub ahead of print] [PMID: 23167714]
  22. Hwang SL, Shih PH, Yen GC. Neuroprotective effects of citrus flavonoids. J Agric Food Chem. 2012 Feb 1;60(4):877-85. DOI: 10.1021/jf204452y. Epub 2012 Jan
  23. Review. [PMID: 22224368] 23. Linus Pauling Institute. Micronutrient Information Center. Flavonoids. http://lpi.oregonstate. edu/info center/phytochemicals/flavonoids/. Updated June 2008. Accessed December 10, 2012.

 

Agape Nutrition is proud to offer:

United States Postal Service (USPS) and United Parcel Service (UPS) as our standard shipping carriers and their services. Shipping rates are determined in real time or carrier book rate by weight and distance. Shipping Options are determined and reflected upon check out, for your choosing. If an option is not listed upon check out, your package may not meet the weight requirement or the service may not be available to the address location. Automated invoices for orders and shipping updates will drop into the email listed on the Agape Nutrition account. If SMS is accepted, automated updates will go to your phone via text message, you may also receive an email.

 

We pride ourselves on providing fast service at competitive prices.

  • Orders received by 12:00 pm Pacific Standard Time (PST) are generally processed the same day, and may ship within 24 hours. However, this is not a guarantee.
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Processing and shipping times are:

  • Estimated and applicable during regular business hours.
  • Dependent upon the daily order volume at Agape Nutrition.
  • Dependent upon the daily order volume at the partner warehouse.
  • Dependent upon the time zones of our manufacture and distributor partners.
  • Dependent upon the shipping service practices and processing standards.

 

 

USPS Holiday Schedule             Agape Nutrition Holiday Schedule                 UPS Holiday Schedule

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 Please Note: No Saturday Delivery Available.

 

Signature may be required for:

  • Orders of a high dollar amount.
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  • Vielight shipments.
  • Richway shipments.
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 We have fixed shipping rates for a select few brand partners as per their shipping rate requirements, which may be different then our own and other distributor warehouses. Brands that apply: Vielight, Richway International, Biotics Research.

Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and / or natural disasters.

Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Due to no carrier guarantees, delayed or late packages are not eligible for refunds. This is a stipulation directly from the shipping carriers and is out of our control.

Shipping Service Guarantees Remain Suspended for Most Shipments. Please reach out to the shipping carrier for more information.

 

SHIPPING DISCOUNTS

 

Please see our FAQ page for additional questions and answers.

All discounts and promotional offers are calculated before shipping and handling rates are applied.


ORDER CANCELLATIONS

Orders cannot be cancelled or changed once the order has been placed and the confirmation is received.

Products may ship faster then expected, and many are automated to process directly after order confirmation. We work directly with top professional manufactures and distributors from across the United States, in all time zones. There are a lot of cogs and wheels turning to process and ship your order efficiently to meet an on time delivery target. When you request a cancellation or change of an order, it may take up to 72 hours to process your request. This process may involve voiding orders in computer systems, removing items from back order logs, pulling items from production schedules and sometimes stopping orders at the shipping dock or warehouse. Our order fulfillment may be performed by many quick hands, in different states and time zones. Therefore, we cannot offer or guarantee order cancellations after the order has been received.

  • Products may process and ship faster then expected.
  • Products may be automated to process directly after the order is confirmed.
  • Product warehouses may be in different states and time zones.
  • Orders may take up to 72 hours to process a cancellation or change. 

 

 DOMESTIC SHIPMENTS

Agape Nutrition is proud to ship to 52 states and territories of the United States.

  • All 50 United States (includes Washington DC, Hawaii, Alaska)
  • Armed Forces: Americas (AA)

Orders shipped to U.S. military addresses (APO/FPO/DPO) will ship via United States Postal Service (USPS) at the carrier book rate; normal delivery of these orders may be delayed by one (1) business day.

 

INTERNATIONAL SHIPMENTS
Agape Nutrition does not offer international shipping at this time, outside the 52 states, including Washington DC and Armed Forces Americas of the United States.

 

HEAT SENSITIVE SHIPMENTS
Products requiring shipment in a cool environment (perishable and frozen items) are subject to special shipping procedures due to their sensitive nature to ensure customers receive products in good condition. Heat sensitive items are shipped using sealed thermal bubble bag, ice pack or brick, resealable bag and extra padding to ensure a cool environment. We do not recommend heat sensitive item ship to territories of the United States, and we cannot be held responsible for cooled environment degradation to these destinations.

Agape Nutrition recommends that heat sensitive products ship with your preference of any 1-3 Day delivery service. We do not offer overnight or next day delivery service at this time. Saturday delivery is not available or guaranteed, unless offered by the shipping carrier as part of the normal delivery.

Please Note:

  • Heat sensitive items are not eligible for return, credit, or refund. As we cannot guarantee cool storage or efficacy of the product, after the order has been delivered.
  • Delays in shipping service delivery, caused an issue? See our return policy for further information.

       

      PACKAGE DELAYS

      Please be aware of severe weather and hazardous conditions in your area or other states that may affect the timeliness of your package delivery. Agape Nutrition can not be responsible for severe weather and unforeseen incidents that may impact the processing times and/or shipping services. We will work to ensure the safety of our employees while minimizing effects on service. Contingency plans are in place to help ensure that shipments arrive at their final destinations as quickly as conditions permit.

       

      Please Be Aware of Any Possible Shipping Delays:

      (1) Slight delays with fulfillment processing may occur as manufacture and distributor warehouses are experiencing higher than normal volume and demand for nutritional items.

      (2) Shipping carriers are experiencing delays. This is due to increased shipments resulting from the COVID-19 pandemic combined with any holidays, and/or natural disasters. Expedited shipping (2-Day, 3-Day, and Next-Day) are not guaranteed by the carriers and does not include weekend delivery. Please reach out to the shipping carrier for more information.

      (3) Please be aware of severe weather conditions in or around your location and surrounding states that my affect the timeliness of delivery.

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