Bioclinic Naturals, PQQ-10 60 Softgels

Benefits

• BioPQQ® is manufactured in Japan using a patented natural fermentation process to enhance absorption – derived from 100% all-natural sourced materials
• PQQ has synergistic activity when combined with CoQ10, providing optimal mitochondrial function and energy production
• Addresses mitochondrial dysfunction and oxidative stress, key determinants of oocyte and sperm quality
• Formulated with vitamin E derived from non-GMO sunflower lecithin

Feature Summary

PQQ and CoQ10 are synergistic nutrients that modulate cellular signaling pathways, neutralize reactive oxygen species, and support optimal mitochondrial function. Mitochondrial dysfunction and oxidative stress are involved in an ever-increasing range of conditions and are thought to play important roles in egg and sperm quality, as well as cellular aging. CoQ10 is well established as a mitochondrial enhancer, with proven benefits in the treatment and prevention of numerous cardiovascular and neurological conditions. CoQ10 also affects oocyte mitochondrial function, sperm quality, and fertility.1,2 CoQ10 increases the efficiency of mitochondrial ATP production and cellular respiration.3

PQQ is a novel biofactor, known to influence multiple cellular pathways, including the production of nerve growth factor (NGF). PQQ has diverse benefits for mitochondrial function and has been shown to attenuate mitochondrial oxidative stress as well as to stimulate mitochondrial biogenesis.4 It also has neuroprotective properties including protection against glutamate-induced toxicity, a pathway common in many neurodegenerative diseases. BioPQQ is considered a novel cofactor with antioxidant and B vitamin-like activity. It is naturally fermented to enhance absorption.5

Taken together, PQQ and CoQ10 have shown clinical benefits for improving cognitive performance such as attention and information processing, cardiovascular health, and providing superior mitochondrial support.6,7

Non-Medicinal Ingredients

Organic flaxseed oil, softgel (gelatin, glycerin, purified water, carob), yellow beeswax, non-GMO sunflower lecithin.

Dosage

Recommended Adult Dose: 1 softgel daily with food or as directed by a health care practitioner.

Warnings

Consult a health care practitioner prior to use if you are pregnant, breastfeeding, or taking blood pressure medication or blood thinners. Keep out of reach of children.

Allergens

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if the seal is broken. For freshness, store in a cool, dry place.

Drug Interactions

Although existing evidence has not found an interaction, CoQ10 resembles vitamin K structurally, potentially interfering with the anticoagulant warfarin. Close monitoring of the INR is recommended with CoQ10 introduction in these patients.

References

Ben-Meir, A., Burstein, E., Borrego-Alvarez, A., et al. (2015). Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell, 14(5), 887-95.

Safarinejad, M.R., Safarinejad, S., Shafiei, N., et al. (2012). Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo-controlled, randomized study. J Urol, 188(2), 526-31.

Takeda, R., Sawabe, A., Nakano, R., et al. (2011). Effect of various food additives and soy constituents on high CoQ10 absorption. Japanese Journal Medicine Pharmaceutical Science, 64(4), 614-20.

Chowanadisai, W., Bauerly, K.A., Tchaparian, E., et al. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increases PGC-1alpha expression. J Biol Chem, 285(1), 142-52.

Rucker, R., Chowanadisai, W., Nakano, M. (2009). Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev, 14(3), 268-77.

Nakano, M., Ubukata, K., Yamamoto, T., et al. (2009). Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. Food Style, 13(7), 50-3.

Littarru, G.P., Tiano, L., Belardinelli, R., et al. (2011). Coenzyme Q(10), endothelial function and cardiovascular disease. Biofactors, 37(5), 366-73.