Mosaic Diagnostics, Urine Organic Acid Test (OAT)

Mosaic Diagnostics Laboratory formerly The Great Plains Laboratory

 How it works:

• Test kits & lab fees are pre-paid through Agape Nutrition, with no option to bill medical insurance at any time.
• We will register your kit with Mosaic Diagnostics Laboratory electronically.
• Stephen Smith M.D. is the referring physician and has authorized the lab to process your kit specimen.
• The kit is mailed to you direct from Mosaic Diagnostics Laboratory.
• Perform test kit, mail with paperwork, using prepaid envelope.
• Test kits are processed through Mosaic Diagnostic Laboratory.
• Results within 3-4 weeks after lab processing.
• The doctor is notified of results through our portal and
• You can access results through our patient portal by following the instructions in the video below. We can also email test results to you upon your request.
• Book an appointment with Dr. Stephen Smith or your own licensed healthcare physician. (Not included in the price of the kit)

MosaicDX How a Patient Accesses Their Test Results from Mosaic Diagnostics on Vimeo.

 

Mosaic Diagnostics Urine Organic Acid Test (OAT):

The Mosaic Diagnostics Urine Organic Acid Test (OAT) is used to take a metabolic snapshot of the body’s functions through the analysis of waste products passed in the urine. Acids present in the urine at certain levels can be indicators of toxicity or even give a reading of how chemical functions are performing at a cellular level. The test can be used to provide markers for inflammation, neurotoxicity, vitamin D deficiency, bone function, exposure to parabens, mitochondrial dysfunction, beneficial bacteria, glutathione deficiency, yeast overgrowth, and the functioning of the Krebs cycle.

Using the Urine Organic Acid Test (OAT) is simple. The specimen is sent to Mosaic Diagnostics Laboratory in a prepaid envelope. All test kits and lab fees are paid through Agape Nutrition, so there’s no need to bill medical insurers. All paperwork can be submitted via the mail or online and results are available between three and four weeks after processing.

Clostridia Detection

 

New Markers: Analyte List

 

Quinolinic Acid - Marker for Inflammation and Neurotoxicity
Quinolinic acid is an organic acid derived from the amino acid tryptophan and can be neurotoxic at high levels. Excitotoxic substances like quinolinic acid may stimulate nerve cells so much that the nerve cells die. Brain toxicity due to quinolinic acid has been implicated in Alzheimer's disease, autism, Huntington's disease, stroke, dementia from old age, depression, HIV-associated dementia, and schizophrenia.

 

Inorganic Phosphate - Marker for Bone Function / Vitamin D Deficiency
Low phosphate is associated with hypoparathyroidism, pseudohypoparathyroidism, low nutritional phosphate intake, parathyroidectomy, and vitamin D deficiency.

 

4-Hydroxybenzoic Acid - Marker for Exposure to Parabens
4-Hydroxybenzoic acid is a metabolite of methylparaben, an anti-fungal agent, and a popular preservative in food and cosmetics. Parabens may be linked to mitochondrial failure due to depletion of cellular ATP through uncoupling of oxidative phosphorylation. They may also be produced from the microbial metabolism of polyphenols in the diet. Parabens have been found at high levels in breast cancer samples, but a definitive relationship with breast cancer has not been demonstrated.

 

4-Hydroxyhippuric Acid - Marker for Exposure to Parabens
4-Hydroxyhippuric, a glycine conjugate of 4-hydroxybenzoic acid, is a metabolite of methylparaben. This compound is increased from the intake of fruits containing polyphenols rich in anthocyanins, flavonols, and hydroxycinnamates, which are metabolized by gastrointestinal bacteria. 4-Hydroxyhippuric acid has been found to be an inhibitor of Calcium-ATPase in end-stage renal failure.

 

Malic Acid - Marker for Mitochondrial Dysfunction
When malic acid is simultaneously elevated with citric, fumaric, and alpha-ketoglutaric acids, it strongly suggests cytochrome C oxidase deficiency, indicating dysfunction in the mitochondrial energy pathways.

 

DHPPA - Marker for Beneficial Bacteria

Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli mediate the breakdown of chlorogenic acid to 3,4-dihydroxy phenyl propionic acid (DHPPA). High values of DHPPA are associated with increased amounts of these bacteria in the gastrointestinal tract.

 

N-acetylcysteine (NAC) - Marker for Glutathione Precursor & Chelating Agent
N-acetylcysteine is a powerful antioxidant that acts to increase the glutathione reserves in the body. It is found in body fluids but is also used as a nutritional supplement. N-acetylcysteine reduces the toxicity of drugs like acetaminophen (Tylenol) and protects against the toxicity of mercury and other heavy metals. Low levels could indicate a glutathione deficiency.

 

Quinolinic Acid / 5-HIAA Ratio - Marker for Neurotoxicity and Inflammation

A high ratio of quinolinic acid to the tryptophan metabolite 5-hydroxy indole-acetic acid indicates excessive inflammation due to recurrent infections, excessive tryptophan intake, immune overstimulation, excessive adrenal production of cortisol, or excessive exposure to phthalates.

 

Other Important Markers

Besides the new markers, the OAT still evaluates other important compounds including the Krebs cycle and neurotransmitters. This reliable test detects the overgrowth of yeast and a bacteria species, Clostridia, commonly missed by conventional culture methods. These organisms and their metabolites can produce or magnify symptoms of many medical conditions. Identification of a yeast or bacterial overgrowth paired with a successful treatment can increase the chance of recovery.

 

Yeast: Intestinal growth of yeast & fungi, including Candida, are measured via by-product. High levels indicate an overgrowth.

 

Bacterial: Intestinal growth of bacteria, including Clostridia species, is measured via by-product. High levels indicate an overgrowth.

 

Oxalates: Elevations may indicate an excess of foods high in oxalates or Vitamin C, digestive disease, B6 deficiency, or intestinal yeast growth. Genetic markers indicate possible hyperoxaluria.

 

Glycolysis: Elevations may result from infection, exercise, or B vitamin deficiency. Very high levels may result from genetic metabolic disorders.

 

Oxalate Control

 

Krebs cycle: Abnormalities may result from nutrient deficiencies, microbial overgrowth, or glutathione (GSH) deficiency.

2-oxoglutaric: Low levels may result from the regeneration of amino acids to remove excess ammonia.

 

Neurotransmitters: Metabolites of dopamine, norepinephrine, adrenaline, and serotonin are measured. Abnormalities may result from stress or poor detoxification, depression, toxic metal exposure, and rarely, specific tumors.

 

Pyrimidines: Slight elevations occur from folic acid deficiency. Significant abnormalities can indicate possible genetic dysfunction.

 

Fatty acids: Abnormalities can occur from ketogenic diets or fasting, intake of medium-chain triglycerides, carnitine deficiency, or genetic disease.

 

Toxic indicators: Abnormalities can occur from deficiency of glutathione, excess ammonia, and aspartame ingestion.

 

Vitamin indicators: Abnormalities involving B12, B6, biotin, ascorbic acid are measured. Amino acids: Abnormalities indicate a possible genetic error.

 

Miscellaneous: Abnormalities can indicate GI microbial activity or genetic disease.

• Clinical Usefulness
• Understand vitamin and hormone metabolism
• Determine capacity to generate energy
• Evaluate intestinal wall integrity
• Assess the performance of the central nervous system
• Evaluate muscle function
• Reveal excessive levels of GI yeast
• Reveal excessive levels of GI bacteria
• Detect nutritional or antioxidant deficiencies
• Determine problems in fatty acid metabolism
• Determine oxalate imbalances

Recommendations:

Depending on test results, follow-up may include:

• Diet modification
• Probiotic supplementation
• Nutritional supplementation
• Oral anti-fungal or anti-bacterial medications
• Increase antioxidants
• Initiate detoxification protocols
• Follow-up genetic testing

Sample Test Report: Organic Acid Test (OAT) Sample Report

 

NOTE: Due to Mosaic Diagnostics Laboratory does not have a contract in the state of New York.

 New York residents are not allowed to perform or mail this test kit for processing within or from the state of New York. Furthermore, Mosaic Diagnostics Laboratory will not process this test kit mailed from the State of New York.

*If you are interested in performing this test kit, you will need to:

1. Perform / Collect the specimen outside of the state of New York.
2. Mail for processing from an address outside of the state of New York.
3. Receive your results to the same address outside of the state of New York.

We are sorry for any inconvenience this may cause.